MIKULA, Přemysl, Marie MLNAŘÍKOVÁ, Enrico T. NADRES, Haruko TAKAHASHI, Pavel BABICA, Kenichi KURODA, Luděk BLÁHA and Iva SOVADINOVÁ. Synthetic Biomimetic Polymethacrylates: Promising Platform for the Design of Anti-Cyanobacterial and Anti-Algal Agents. Carbohydrate Polymers. BASEL: MDPI, 2021, vol. 13, No 7, p. 1-16. ISSN 0144-8617. doi:10.3390/polym13071025.
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Basic information
Original name Synthetic Biomimetic Polymethacrylates: Promising Platform for the Design of Anti-Cyanobacterial and Anti-Algal Agents
Authors MIKULA, Přemysl (203 Czech Republic, belonging to the institution), Marie MLNAŘÍKOVÁ (203 Czech Republic, belonging to the institution), Enrico T. NADRES (840 United States of America), Haruko TAKAHASHI (840 United States of America), Pavel BABICA (203 Czech Republic, belonging to the institution), Kenichi KURODA (840 United States of America), Luděk BLÁHA (203 Czech Republic, guarantor, belonging to the institution) and Iva SOVADINOVÁ (203 Czech Republic, belonging to the institution).
Edition Carbohydrate Polymers, BASEL, MDPI, 2021, 0144-8617.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10404 Polymer science
Country of publisher Switzerland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 9.381 in 2020
Organization unit Faculty of Science
Doi http://dx.doi.org/10.3390/polym13071025
UT WoS 000638778200001
Keywords in English algae; antimicrobials; biomimetic polymers; cyanobacteria; polymethacrylates; water treatment
Tags International impact, Reviewed
Changed by Changed by: Mgr. Michaela Hylsová, Ph.D., učo 211937. Changed: 14/8/2021 21:17.
Extensive, uncontrolled growth of algae and cyanobacteria is an environmental, public health, economic, and technical issue in managing natural and engineered water systems. Synthetic biomimetic polymers have been almost exclusively considered antimicrobial alternatives to conventional antibiotics to treat human bacterial infections. Very little is known about their applicability in an aquatic environment. Here, we introduce synthetic biomimetic polymethacrylates (SBPs) as a cost-effective and chemically facile, flexible platform for designing a new type of agent suitable for controlling and mitigating photosynthetic microorganisms. Since SBPs are cationic and membranolytic in heterotrophic bacteria, we hypothesized they could also interact with negatively charged cyanobacterial or algal cell walls and membranes. We demonstrated that SBPs inhibited the growth of aquatic photosynthetic organisms of concern, i.e., cyanobacteria (Microcystis aeruginosa and Synechococcus elongatus) and green algae (Chlamydomonas reinhardtii and Desmodesmus quadricauda), with 50% effective growth-inhibiting concentrations ranging between 95 nM and 6.5 mu M. Additionally, SBPs exhibited algicidal effects on C. reinhardtii and cyanocidal effects on picocyanobacterium S. elongatus and microcystin-producing cyanobacterium M. aeruginosa. SBP copolymers, particularly those with moderate hydrophobic content, induced more potent cyanostatic and cyanocidal effects than homopolymers. Thus, biomimetic polymers are a promising platform for the design of anti-cyanobacterial and anti-algal agents for water treatment.
EF17_043/0009632, research and development projectName: CETOCOEN Excellence
LM2018121, research and development projectName: Výzkumná infrastruktura RECETOX (Acronym: RECETOX RI)
Investor: Ministry of Education, Youth and Sports of the CR, Large Infrastructures for Research, Development and Innovation
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