Helicobacter pylori infection and other bacteria in pancreatic
cancer and autoimmune pancreatitis

J 2021

Helicobacter pylori infection and other bacteria in pancreatic cancer and autoimmune pancreatitis

KUNOVSKÝ, Lumír, Petr DÍTĚ, Petr JABANDŽIEV, Jiří DOLINA, Jitka VACULOVÁ et. al.

Basic information

Original name

Helicobacter pylori infection and other bacteria in pancreatic cancer and autoimmune pancreatitis

Authors

KUNOVSKÝ, Lumír (203 Czech Republic, belonging to the institution), Petr DÍTĚ (203 Czech Republic, belonging to the institution), Petr JABANDŽIEV (203 Czech Republic, belonging to the institution), Jiří DOLINA (203 Czech Republic, belonging to the institution), Jitka VACULOVÁ (203 Czech Republic, belonging to the institution), Martin BLAHO (203 Czech Republic), Martina BOJKOVA (203 Czech Republic), Jana DVORACKOVA (203 Czech Republic), Magdalena UVIROVA (203 Czech Republic), Zdeněk KALA (203 Czech Republic, belonging to the institution) and Jan TRNA (203 Czech Republic, guarantor, belonging to the institution)

Edition

World Journal of Gastrointestinal Oncology, Pleasanton, Baishideng Publishing Group, 2021, 1948-5204

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30219 Gastroenterology and hepatology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.404

RIV identification code

RIV/00216224:14110/21:00120117

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.4251/wjgo.v13.i8.835

UT WoS

000691097800005

Keywords in English

Helicobacter pylori; Pancreatic cancer; Autoimmune pancreatitis; Carcinogenesis; Microbiome; Molecular mimicry

Abstract

V originále

Helicobacter pylori (H. pylori) is an infectious agent influencing as much as 50% of the world’s population. It is the causative agent for several diseases, most especially gastric and duodenal peptic ulcer, gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma of the stomach. A number of other, extragastric manifestations also are associated with H. pylori infection. These include neurological disorders, such as Alzheimer’s disease, demyelinating multiple sclerosis and Parkinson’s disease. There is also evidence for a relationship between H. pylori infection and such dermatological diseases as psoriasis and rosacea as well as a connection with infection and open-angle glaucoma. Generally little is known about the relationship between H. pylori infection and diseases of the pancreas. Most evidence about H. pylori and its potential role in the development of pancreatic diseases concerns pancreatic adenocarcinoma and autoimmune forms of chronic pancreatitis. There is data (albeit not fully consistent) indicating modestly increased pancreatic cancer risk in H. pylori-positive patients. The pathogenetic mechanism of this increase is not yet fully elucidated, but several theories have been proposed. Reduction of antral D-cells in H. pylori-positive patients causes a suppression of somatostatin secretion that, in turn, stimulates increased secretin secretion. That stimulates pancreatic growth and thus increases the risk of carcinogenesis. Alternatively, H. pylori, as a part of microbiome dysbiosis and the so-called oncobiome, is proven to be associated with pancreatic adenocarcinoma development via the promotion of cellular proliferation. The role of H. pylori in the inflammation characteristic of autoimmune pancreatitis seems to be explained by a mechanism of molecular mimicry among several proteins (mostly enzymes) of H. pylori and pancreatic tissue. Patients with autoimmune pancreatitis often show positivity for antibodies against H. pylori proteins. H. pylori, as a part of microbiome dysbiosis, also is viewed as a potential trigger of autoimmune inflammation of the pancreas. It is precisely these relationships (and associated equivocal conclusions) that constitute a center of attention among pancreatologists, immunologists and pathologists. In order to obtain clear and valid results, more studies on sufficiently large cohorts of patients are needed. The topic is itself sufficiently significant to draw the interest of clinicians and inspire further systematic research. Next-generation sequencing could play an important role in investigating the microbiome as a potential diagnostic and prognostic biomarker for pancreatic cancer.

Links

NU20-03-00126, research and development project

Name: Hostitelský mikrobiom ve vztahu k rozvoji Barrettova jícnu a adenokarcinomu jícnu

Investor: Ministry of Health of the CR, Host microbiome in relation to Barrett ́s esophagus and esophageal adenocarcinoma development, Subprogram 1 - standard

Citovat

KUNOVSKÝ, Lumír, Petr DÍTĚ, Petr JABANDŽIEV, Jiří DOLINA, Jitka VACULOVÁ, Martin BLAHO, Martina BOJKOVA, Jana DVORACKOVA, Magdalena UVIROVA, Zdeněk KALA and Jan TRNA. Helicobacter pylori infection and other bacteria in pancreatic cancer and autoimmune pancreatitis. World Journal of Gastrointestinal Oncology. Pleasanton: Baishideng Publishing Group, 2021, vol. 13, No 8, p. 835-844. ISSN 1948-5204. Available from: https://dx.doi.org/10.4251/wjgo.v13.i8.835.

@article{1786627,
   author = {Kunovský, Lumír and Dítě, Petr and Jabandžiev, Petr and Dolina, Jiří and Vaculová, Jitka and Blaho, Martin and Bojkova, Martina and Dvorackova, Jana and Uvirova, Magdalena and Kala, Zdeněk and Trna, Jan},
   article_location = {Pleasanton},
   article_number = {8},
   doi = {http://dx.doi.org/10.4251/wjgo.v13.i8.835},
   keywords = {Helicobacter pylori; Pancreatic cancer; Autoimmune pancreatitis; Carcinogenesis; Microbiome; Molecular mimicry},
   language = {eng},
   issn = {1948-5204},
   journal = {World Journal of Gastrointestinal Oncology},
   title = {Helicobacter pylori infection and other bacteria in pancreatic cancer and autoimmune pancreatitis},
   url = {https://www.wjgnet.com/1948-5204/full/v13/i8/835.htm},
   volume = {13},
   year = {2021}
}

TY  - JOUR
ID  - 1786627
AU  - Kunovský, Lumír - Dítě, Petr - Jabandžiev, Petr - Dolina, Jiří - Vaculová, Jitka - Blaho, Martin - Bojkova, Martina - Dvorackova, Jana - Uvirova, Magdalena - Kala, Zdeněk - Trna, Jan
PY  - 2021
TI  - Helicobacter pylori infection and other bacteria in pancreatic cancer and autoimmune pancreatitis
JF  - World Journal of Gastrointestinal Oncology
VL  - 13
IS  - 8
SP  - 835-844
EP  - 835-844
PB  - Baishideng Publishing Group
SN  - 19485204
KW  - Helicobacter pylori
KW  - Pancreatic cancer
KW  - Autoimmune pancreatitis
KW  - Carcinogenesis
KW  - Microbiome
KW  - Molecular mimicry
UR  - https://www.wjgnet.com/1948-5204/full/v13/i8/835.htm
N2  - Helicobacter pylori (H. pylori) is an infectious agent influencing as much as 50% of the world’s population. It is the causative agent for several diseases, most especially gastric and duodenal peptic ulcer, gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma of the stomach. A number of other, extragastric manifestations also are associated with H. pylori infection. These include neurological disorders, such as Alzheimer’s disease, demyelinating multiple sclerosis and Parkinson’s disease. There is also evidence for a relationship between H. pylori infection and such dermatological diseases as psoriasis and rosacea as well as a connection with infection and open-angle glaucoma. Generally little is known about the relationship between H. pylori infection and diseases of the pancreas. Most evidence about H. pylori and its potential role in the development of pancreatic diseases concerns pancreatic adenocarcinoma and autoimmune forms of chronic pancreatitis. There is data (albeit not fully consistent) indicating modestly increased pancreatic cancer risk in H. pylori-positive patients. The pathogenetic mechanism of this increase is not yet fully elucidated, but several theories have been proposed. Reduction of antral D-cells in H. pylori-positive patients causes a suppression of somatostatin secretion that, in turn, stimulates increased secretin secretion. That stimulates pancreatic growth and thus increases the risk of carcinogenesis. Alternatively, H. pylori, as a part of microbiome dysbiosis and the so-called oncobiome, is proven to be associated with pancreatic adenocarcinoma development via the promotion of cellular proliferation. The role of H. pylori in the inflammation characteristic of autoimmune pancreatitis seems to be explained by a mechanism of molecular mimicry among several proteins (mostly enzymes) of H. pylori and pancreatic tissue. Patients with autoimmune pancreatitis often show positivity for antibodies against H. pylori proteins. H. pylori, as a part of microbiome dysbiosis, also is viewed as a potential trigger of autoimmune inflammation of the pancreas. It is precisely these relationships (and associated equivocal conclusions) that constitute a center of attention among pancreatologists, immunologists and pathologists. In order to obtain clear and valid results, more studies on sufficiently large cohorts of patients are needed. The topic is itself sufficiently significant to draw the interest of clinicians and inspire further systematic research. Next-generation sequencing could play an important role in investigating the microbiome as a potential diagnostic and prognostic biomarker for pancreatic cancer.
ER  -

KUNOVSKÝ, Lumír, Petr DÍTĚ, Petr JABANDŽIEV, Jiří DOLINA, Jitka VACULOVÁ, Martin BLAHO, Martina BOJKOVA, Jana DVORACKOVA, Magdalena UVIROVA, Zdeněk KALA and Jan TRNA. Helicobacter pylori infection and other bacteria in pancreatic cancer and autoimmune pancreatitis. \textit{World Journal of Gastrointestinal Oncology}. Pleasanton: Baishideng Publishing Group, 2021, vol.~13, No~8, p.~835-844. ISSN~1948-5204. Available from: https://dx.doi.org/10.4251/wjgo.v13.i8.835.

Detailed Information on Publication Record