2022
Association of the CD14 -260C/T polymorphism with plaque-induced gingivitis depends on the presence of Porphyromonas gingivalis
BARTOŠOVÁ, Michaela; Petra BOŘILOVÁ LINHARTOVÁ; Kristína MUSILOVÁ; Zdeněk BROUKAL; Martina KUKLETOVÁ et. al.Basic information
Original name
Association of the CD14 -260C/T polymorphism with plaque-induced gingivitis depends on the presence of Porphyromonas gingivalis
Name in Czech
Vztah polymorfizmu CD14 -260C/T u plakem indukované gingivitidy a přítomností bakterie Porphyromonas gingivalis
Authors
BARTOŠOVÁ, Michaela; Petra BOŘILOVÁ LINHARTOVÁ; Kristína MUSILOVÁ; Zdeněk BROUKAL; Martina KUKLETOVÁ; Lubomír KUKLA and Lydie IZAKOVIČOVÁ HOLLÁ
Edition
International Journal of Paediatric Dentistry, Hoboken, Wiley, 2022, 0960-7439
Other information
Language
English
Type of outcome
Article in a journal
Field of Study
30209 Paediatrics
Country of publisher
United States of America
Confidentiality degree
is not subject to a state or trade secret
References:
Impact factor
Impact factor: 3.800
RIV identification code
RIV/00216224:14110/22:00124966
Organization unit
Faculty of Medicine
UT WoS
000661667900001
EID Scopus
2-s2.0-85107983660
Keywords (in Czech)
bakterie; CD14; gingivitida; polymorfizmus
Keywords in English
bacteria; CD14; gingivitis; polymorphism
Tags
International impact, Reviewed
Changed: 9/6/2025 14:34, Mgr. Michaela Hylsová, Ph.D.
In the original language
This study investigated the association between the functional polymorphism in the CD14 gene and the dental plaque microbiota in children with gingivitis.Gingivitis was detected in 64.2% of boys, but only in 35.8% of girls (P < .001). Children with gingivitis had a significantly higher occurrence of dental caries (P < .001). No significant differences in the CD14 -260C/T allele and genotype distribution among individuals with or without gingivitis in the whole cohort were found. Children with gingivitis and P gingivalis, however, were significantly more frequent carriers of the CT and TT genotypes than children with gingivitis without P gingivalis or healthy controls (P < .05).
In Czech
Cílem studie bylo analyzovat vztah mezi polymorfizmem v genu CD14 a bakteriemi zubního plaku u dětí postižených gingivitidou. Gingivitida byla diagnostikována u 64, 2 % chlapců a 35, 8 % dívek (P < ,001). U dětí s gingivitidou byl signifikantně častěji diagnostikován zubní kaz (P < ,001). Nenalezli jsme statisticky významný rozdíl v rozložení alel ani genotypů polymorfizmu CD14 -260C/T mezi pacienty s a bez gingivitidy. Avšak děti postižené gingvitidou, u kterých jsme prokázali přítomnost bakterie P gingivalis, byli signifikantně častěji nositelem CT a TT genotypu než děti postižené gingivitidou bez přítommnosti bakterie P. gingivalis nebo děti zdravé (P < .05).
Links
| MUNI/A/1675/2020, interní kód MU |
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| NV17-30439A, research and development project |
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| ROZV/28/LF1/2020, interní kód MU |
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| 90028, large research infrastructures |
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