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@article{1786717,
author = {Brat, Kristián and Svoboda, Michal and Hejduk, Karel and Plutinský, Marek and Zatloukal, Jaromir and Volakova, Eva and Popelkova, Patrice and Novotna, Barbora and Engova, Dita and Franssen, Frits M. E. and Vanfleteren, Lowie E. G. W. and Spruit, Martijn A. and Koblizek, Vladimir},
article_location = {Olomouc},
article_number = {2},
doi = {http://dx.doi.org/10.5507/bp.2020.035},
keywords = {COPD; prognostic index; pulmonary function; mortality},
language = {eng},
issn = {1213-8118},
journal = {Biomedical Papers, Olomouc: Palacky University},
title = {Introducing a new prognostic instrument for long-term mortality prediction in COPD patients: the CADOT index},
url = {https://biomed.papers.upol.cz/artkey/bio-202102-0004_introducing-a-new-prognostic-instrument-for-long-term-mortality-prediction-in-copd-patients-the-cadot-index.php},
volume = {165},
year = {2021}
}
TY - JOUR
ID - 1786717
AU - Brat, Kristián - Svoboda, Michal - Hejduk, Karel - Plutinský, Marek - Zatloukal, Jaromir - Volakova, Eva - Popelkova, Patrice - Novotna, Barbora - Engova, Dita - Franssen, Frits M. E. - Vanfleteren, Lowie E. G. W. - Spruit, Martijn A. - Koblizek, Vladimir
PY - 2021
TI - Introducing a new prognostic instrument for long-term mortality prediction in COPD patients: the CADOT index
JF - Biomedical Papers, Olomouc: Palacky University
VL - 165
IS - 2
SP - 139-145
EP - 139-145
PB - Palacky University
SN - 12138118
KW - COPD
KW - prognostic index
KW - pulmonary function
KW - mortality
UR - https://biomed.papers.upol.cz/artkey/bio-202102-0004_introducing-a-new-prognostic-instrument-for-long-term-mortality-prediction-in-copd-patients-the-cadot-index.php
N2 - Objectives. The BODE (BMI, Obstruction - FEV1, Dyspnoea - mMRC, Exercise - 6-MWT) and the ADO (Age, Dyspnoea - mMRC, Obstruction - FEV1) indices are widely used prognosis assessment tools for long-term mortality prediction in COPD patients but subject to limitations for use in daily clinical practice. The aim of this research was to construct a prognostic instrument that prevents these limitations and which would serve as a complementary prognostic tool for clinical use in these patients. Methods and Participants. The data of 699 COPD subjects were extracted from the Czech Multicentre Research Database (CMRD) of COPD patients (the derivation cohort) and analysed to identify factors associated with the long-term risk of mortality. These were entered into the ROC analysis and reclassification analysis. Those with the strongest discriminative power were used to construct the new index (CADOT). The new index was validated on 187 patients of the CIROCO+ cohort (Netherlands; the validation cohort). Results. The CADOT was constructed by adding two newly identified prognosis-determining factors, chronic heart failure (CHF) and TLCO, to the ADO index. In a head-to-head comparison, the CADOT index showed highest c-statistic values compared to the BODE and ADO indices (0.701 vs 0.677 vs 0.644, respectively). The prognostic power was more definitive when applied to the Dutch validation (CIROCO+) cohort (0.842 vs 0.799 vs 0.825, respectively). Conclusions. The CADOT index has comparable prognostic power to the BODE and ADO indices.The CADOT is complementary/an alternative to the BODE (if 6-MWT is not feasible) and ADO (with less dependence on the age factor) indices.
ER -
BRAT, Kristián, Michal SVOBODA, Karel HEJDUK, Marek PLUTINSKÝ, Jaromir ZATLOUKAL, Eva VOLAKOVA, Patrice POPELKOVA, Barbora NOVOTNA, Dita ENGOVA, Frits M. E. FRANSSEN, Lowie E. G. W. VANFLETEREN, Martijn A. SPRUIT and Vladimir KOBLIZEK. Introducing a new prognostic instrument for long-term mortality prediction in COPD patients: the CADOT index. \textit{Biomedical Papers, Olomouc: Palacky University}. Olomouc: Palacky University, 2021, vol.~165, No~2, p.~139-145. ISSN~1213-8118. Available from: https://dx.doi.org/10.5507/bp.2020.035.
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