Introducing a new prognostic instrument for long-term mortality
prediction in COPD patients: the CADOT index

J 2021

Introducing a new prognostic instrument for long-term mortality prediction in COPD patients: the CADOT index

BRAT, Kristián, Michal SVOBODA, Karel HEJDUK, Marek PLUTINSKÝ, Jaromir ZATLOUKAL et. al.

Basic information

Original name

Introducing a new prognostic instrument for long-term mortality prediction in COPD patients: the CADOT index

Authors

BRAT, Kristián (703 Slovakia, guarantor, belonging to the institution), Michal SVOBODA (203 Czech Republic, belonging to the institution), Karel HEJDUK (203 Czech Republic, belonging to the institution), Marek PLUTINSKÝ (703 Slovakia, belonging to the institution), Jaromir ZATLOUKAL (203 Czech Republic), Eva VOLAKOVA (203 Czech Republic), Patrice POPELKOVA (203 Czech Republic), Barbora NOVOTNA (203 Czech Republic), Dita ENGOVA (203 Czech Republic), Frits M. E. FRANSSEN (528 Netherlands), Lowie E. G. W. VANFLETEREN (752 Sweden), Martijn A. SPRUIT (528 Netherlands) and Vladimir KOBLIZEK (203 Czech Republic)

Edition

Biomedical Papers, Olomouc: Palacky University, Olomouc, Palacky University, 2021, 1213-8118

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

20601 Medical engineering

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 1.648

RIV identification code

RIV/00216224:14110/21:00122107

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.5507/bp.2020.035

UT WoS

000660244900004

Keywords in English

COPD; prognostic index; pulmonary function; mortality

Abstract

V originále

Objectives. The BODE (BMI, Obstruction - FEV1, Dyspnoea - mMRC, Exercise - 6-MWT) and the ADO (Age, Dyspnoea - mMRC, Obstruction - FEV1) indices are widely used prognosis assessment tools for long-term mortality prediction in COPD patients but subject to limitations for use in daily clinical practice. The aim of this research was to construct a prognostic instrument that prevents these limitations and which would serve as a complementary prognostic tool for clinical use in these patients. Methods and Participants. The data of 699 COPD subjects were extracted from the Czech Multicentre Research Database (CMRD) of COPD patients (the derivation cohort) and analysed to identify factors associated with the long-term risk of mortality. These were entered into the ROC analysis and reclassification analysis. Those with the strongest discriminative power were used to construct the new index (CADOT). The new index was validated on 187 patients of the CIROCO+ cohort (Netherlands; the validation cohort). Results. The CADOT was constructed by adding two newly identified prognosis-determining factors, chronic heart failure (CHF) and TLCO, to the ADO index. In a head-to-head comparison, the CADOT index showed highest c-statistic values compared to the BODE and ADO indices (0.701 vs 0.677 vs 0.644, respectively). The prognostic power was more definitive when applied to the Dutch validation (CIROCO+) cohort (0.842 vs 0.799 vs 0.825, respectively). Conclusions. The CADOT index has comparable prognostic power to the BODE and ADO indices.The CADOT is complementary/an alternative to the BODE (if 6-MWT is not feasible) and ADO (with less dependence on the age factor) indices.

Links

15/14/NAP, interní kód MU

Name: Sledování výskytu deficitu alfa 1 antitrypsinu u pacientů s těžkou formou CHOPN

Investor: Ministry of Health of the CR

5/15/NAP, interní kód MU

Name: Diagnostika bronchogenního karcinomu u nemocných s těžkou formou CHOPN pomocí výpočetní tomografie

Investor: Ministry of Health of the CR

Citovat

BRAT, Kristián, Michal SVOBODA, Karel HEJDUK, Marek PLUTINSKÝ, Jaromir ZATLOUKAL, Eva VOLAKOVA, Patrice POPELKOVA, Barbora NOVOTNA, Dita ENGOVA, Frits M. E. FRANSSEN, Lowie E. G. W. VANFLETEREN, Martijn A. SPRUIT and Vladimir KOBLIZEK. Introducing a new prognostic instrument for long-term mortality prediction in COPD patients: the CADOT index. Biomedical Papers, Olomouc: Palacky University. Olomouc: Palacky University, 2021, vol. 165, No 2, p. 139-145. ISSN 1213-8118. Available from: https://dx.doi.org/10.5507/bp.2020.035.

@article{1786717,
   author = {Brat, Kristián and Svoboda, Michal and Hejduk, Karel and Plutinský, Marek and Zatloukal, Jaromir and Volakova, Eva and Popelkova, Patrice and Novotna, Barbora and Engova, Dita and Franssen, Frits M. E. and Vanfleteren, Lowie E. G. W. and Spruit, Martijn A. and Koblizek, Vladimir},
   article_location = {Olomouc},
   article_number = {2},
   doi = {http://dx.doi.org/10.5507/bp.2020.035},
   keywords = {COPD; prognostic index; pulmonary function; mortality},
   language = {eng},
   issn = {1213-8118},
   journal = {Biomedical Papers, Olomouc: Palacky University},
   title = {Introducing a new prognostic instrument for long-term mortality prediction in COPD patients: the CADOT index},
   url = {https://biomed.papers.upol.cz/artkey/bio-202102-0004_introducing-a-new-prognostic-instrument-for-long-term-mortality-prediction-in-copd-patients-the-cadot-index.php},
   volume = {165},
   year = {2021}
}

TY  - JOUR
ID  - 1786717
AU  - Brat, Kristián - Svoboda, Michal - Hejduk, Karel - Plutinský, Marek - Zatloukal, Jaromir - Volakova, Eva - Popelkova, Patrice - Novotna, Barbora - Engova, Dita - Franssen, Frits M. E. - Vanfleteren, Lowie E. G. W. - Spruit, Martijn A. - Koblizek, Vladimir
PY  - 2021
TI  - Introducing a new prognostic instrument for long-term mortality prediction in COPD patients: the CADOT index
JF  - Biomedical Papers, Olomouc: Palacky University
VL  - 165
IS  - 2
SP  - 139-145
EP  - 139-145
PB  - Palacky University
SN  - 12138118
KW  - COPD
KW  - prognostic index
KW  - pulmonary function
KW  - mortality
UR  - https://biomed.papers.upol.cz/artkey/bio-202102-0004_introducing-a-new-prognostic-instrument-for-long-term-mortality-prediction-in-copd-patients-the-cadot-index.php
N2  - Objectives. The BODE (BMI, Obstruction - FEV1, Dyspnoea - mMRC, Exercise - 6-MWT) and the ADO (Age, Dyspnoea - mMRC, Obstruction - FEV1) indices are widely used prognosis assessment tools for long-term mortality prediction in COPD patients but subject to limitations for use in daily clinical practice. The aim of this research was to construct a prognostic instrument that prevents these limitations and which would serve as a complementary prognostic tool for clinical use in these patients. Methods and Participants. The data of 699 COPD subjects were extracted from the Czech Multicentre Research Database (CMRD) of COPD patients (the derivation cohort) and analysed to identify factors associated with the long-term risk of mortality. These were entered into the ROC analysis and reclassification analysis. Those with the strongest discriminative power were used to construct the new index (CADOT). The new index was validated on 187 patients of the CIROCO+ cohort (Netherlands; the validation cohort). Results. The CADOT was constructed by adding two newly identified prognosis-determining factors, chronic heart failure (CHF) and TLCO, to the ADO index. In a head-to-head comparison, the CADOT index showed highest c-statistic values compared to the BODE and ADO indices (0.701 vs 0.677 vs 0.644, respectively). The prognostic power was more definitive when applied to the Dutch validation (CIROCO+) cohort (0.842 vs 0.799 vs 0.825, respectively). Conclusions. The CADOT index has comparable prognostic power to the BODE and ADO indices.The CADOT is complementary/an alternative to the BODE (if 6-MWT is not feasible) and ADO (with less dependence on the age factor) indices.
ER  -

BRAT, Kristián, Michal SVOBODA, Karel HEJDUK, Marek PLUTINSKÝ, Jaromir ZATLOUKAL, Eva VOLAKOVA, Patrice POPELKOVA, Barbora NOVOTNA, Dita ENGOVA, Frits M. E. FRANSSEN, Lowie E. G. W. VANFLETEREN, Martijn A. SPRUIT and Vladimir KOBLIZEK. Introducing a new prognostic instrument for long-term mortality prediction in COPD patients: the CADOT index. \textit{Biomedical Papers, Olomouc: Palacky University}. Olomouc: Palacky University, 2021, vol.~165, No~2, p.~139-145. ISSN~1213-8118. Available from: https://dx.doi.org/10.5507/bp.2020.035.

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