| KOHLMAIER, B., N. SCHWEINTZGER, M. SAGMEISTER, Vendula SVENDOVA, D. KOHLFURST, A. SONNLEITNER, M. LEITNER, A. BERGHOLD, E. SCHMIEDBERGER, F. FAZEKAS, A. PICHLER, J. REJC-MARKO, Daniel RUZEK, Lucie DUFKOVA, Darina CEJKOVA, Petr HUSA, Martina PÝCHOVÁ, Lenka KRBKOVÁ, Vaclav CHMELIK, Vera STRUNCOVA, D. ZAVADSKA, G. KARELIS, A. MICKIENE, J. ZAJKOWSKA, P. BOGOVIC, F. STRLE and W. ZENZ. Clinical Characteristics of Patients with Tick-Borne Encephalitis (TBE): A European Multicentre Study from 2010 to 2017. Microorganisms. Basel: MDPI, 2021, vol. 9, No 7, p. 1-15. ISSN 2076-2607. Available from: https://dx.doi.org/10.3390/microorganisms9071420. |
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@article{1786739,
author = {Kohlmaier, B. and Schweintzger, N. and Sagmeister, M. and Svendova, Vendula and Kohlfurst, D. and Sonnleitner, A. and Leitner, M. and Berghold, A. and Schmiedberger, E. and Fazekas, F. and Pichler, A. and RejcandMarko, J. and Ruzek, Daniel and Dufkova, Lucie and Cejkova, Darina and Husa, Petr and Pýchová, Martina and Krbková, Lenka and Chmelik, Vaclav and Struncova, Vera and Zavadska, D. and Karelis, G. and Mickiene, A. and Zajkowska, J. and Bogovic, P. and Strle, F. and Zenz, W.},
article_location = {Basel},
article_number = {7},
doi = {http://dx.doi.org/10.3390/microorganisms9071420},
keywords = {tick-borne encephalitis; vaccine-preventable disease; meningomyelitis; central paresis; peripheral paresis},
language = {eng},
issn = {2076-2607},
journal = {Microorganisms},
title = {Clinical Characteristics of Patients with Tick-Borne Encephalitis (TBE): A European Multicentre Study from 2010 to 2017},
url = {https://www.mdpi.com/2076-2607/9/7/1420},
volume = {9},
year = {2021}
}
TY - JOUR
ID - 1786739
AU - Kohlmaier, B. - Schweintzger, N. - Sagmeister, M. - Svendova, Vendula - Kohlfurst, D. - Sonnleitner, A. - Leitner, M. - Berghold, A. - Schmiedberger, E. - Fazekas, F. - Pichler, A. - Rejc-Marko, J. - Ruzek, Daniel - Dufkova, Lucie - Cejkova, Darina - Husa, Petr - Pýchová, Martina - Krbková, Lenka - Chmelik, Vaclav - Struncova, Vera - Zavadska, D. - Karelis, G. - Mickiene, A. - Zajkowska, J. - Bogovic, P. - Strle, F. - Zenz, W.
PY - 2021
TI - Clinical Characteristics of Patients with Tick-Borne Encephalitis (TBE): A European Multicentre Study from 2010 to 2017
JF - Microorganisms
VL - 9
IS - 7
SP - 1-15
EP - 1-15
PB - MDPI
SN - 20762607
KW - tick-borne encephalitis
KW - vaccine-preventable disease
KW - meningomyelitis
KW - central paresis
KW - peripheral paresis
UR - https://www.mdpi.com/2076-2607/9/7/1420
N2 - Tick-borne encephalitis (TBE) virus is a major cause of central nervous system infections in endemic countries. Here, we present clinical and laboratory characteristics of a large international cohort of patients with confirmed TBE using a uniform clinical protocol. Patients were recruited in eight centers from six European countries between 2010 and 2017. A detailed description of clinical signs and symptoms was recorded. The obtained information enabled a reliable classification in 553 of 555 patients: 207 (37.3%) had meningitis, 273 (49.2%) meningoencephalitis, 15 (2.7%) meningomyelitis, and 58 (10.5%) meningoencephalomyelitis; 41 (7.4%) patients had a peripheral paresis of extremities, 13 (2.3%) a central paresis of extremities, and 25 (4.5%) had single or multiple cranial nerve palsies. Five (0.9%) patients died during acute illness. Outcome at discharge was recorded in 298 patients. Of 176 (59.1%) patients with incomplete recovery, 80 (27%) displayed persisting symptoms or signs without recovery expectation. This study provides further evidence that TBE is a severe disease with a large proportion of patients with incomplete recovery. We suggest monitoring TBE in endemic European countries using a uniform protocol to record the full clinical spectrum of the disease.
ER -
KOHLMAIER, B., N. SCHWEINTZGER, M. SAGMEISTER, Vendula SVENDOVA, D. KOHLFURST, A. SONNLEITNER, M. LEITNER, A. BERGHOLD, E. SCHMIEDBERGER, F. FAZEKAS, A. PICHLER, J. REJC-MARKO, Daniel RUZEK, Lucie DUFKOVA, Darina CEJKOVA, Petr HUSA, Martina PÝCHOVÁ, Lenka KRBKOVÁ, Vaclav CHMELIK, Vera STRUNCOVA, D. ZAVADSKA, G. KARELIS, A. MICKIENE, J. ZAJKOWSKA, P. BOGOVIC, F. STRLE and W. ZENZ. Clinical Characteristics of Patients with Tick-Borne Encephalitis (TBE): A European Multicentre Study from 2010 to 2017. \textit{Microorganisms}. Basel: MDPI, 2021, vol.~9, No~7, p.~1-15. ISSN~2076-2607. Available from: https://dx.doi.org/10.3390/microorganisms9071420.
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