Differences in risk profiles and long-term outcomes in acute
heart failure patients with preserved and reduced left
ventricular ejection fraction in the Czech Republic: The AHEAD
registry sub-analysis

J 2021

Differences in risk profiles and long-term outcomes in acute heart failure patients with preserved and reduced left ventricular ejection fraction in the Czech Republic: The AHEAD registry sub-analysis

MIKLIK, Roman, Marie MIKLÍKOVÁ, Radim SPACEK, Jindřich ŠPINAR, Kamil ZEMAN et. al.

Basic information

Original name

Differences in risk profiles and long-term outcomes in acute heart failure patients with preserved and reduced left ventricular ejection fraction in the Czech Republic: The AHEAD registry sub-analysis

Authors

MIKLIK, Roman (203 Czech Republic), Marie MIKLÍKOVÁ (203 Czech Republic, belonging to the institution), Radim SPACEK (203 Czech Republic), Jindřich ŠPINAR (203 Czech Republic, belonging to the institution), Kamil ZEMAN (203 Czech Republic), Klára BENEŠOVÁ (203 Czech Republic, belonging to the institution), Marián FELŠÖCI (703 Slovakia), Lidka POHLUDKOVA (203 Czech Republic), Ladislav DUŠEK (203 Czech Republic, belonging to the institution), Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution), Petr LOKAJ (203 Czech Republic, belonging to the institution), Ilona PARENICOVA (203 Czech Republic) and Jiří PAŘENICA (203 Czech Republic, belonging to the institution)

Edition

Biomedical Papers, Olomouc: Palacky University, Olomouc, Palacky University, 2021, 1213-8118

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

20601 Medical engineering

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 1.648

RIV identification code

RIV/00216224:14110/21:00122112

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.5507/bp.2020.038

UT WoS

000629606300006

Keywords in English

acute heart failure; left ventricular ejection fraction; rehospitalization; AHEAD; mortality

Abstract

V originále

Background. The latest European heart failure guidelines define patients as those with reduced (HFrEF), mid-range, and preserved (HFpEF) left ventricular ejection fraction (LVEF; <40%, 40%-49%, and >= 50%, respectively). We investigated the causes of rehospitalizations/deaths in our institution's heart failure patients and focused on differences in the clinical presentation, risk profile, and long-term outcomes between the HFrEF and HFpEF groups in a real-life scenario. Methods and Results. We followed 1274 patients discharged from heart failure hospitalization in 2 centres. The mean patient age was 75.9 years, and men and women were represented equally. During the minimal follow-up of 2 years, 57% of patients were hospitalised for any cause, 24.9% for decompensated heart failure, and 43.3% for any cardiovascular cause. A total of 36.1% of patients died, either with prior (11.8%) or without prior (24.3%) heart failure rehospitalization. Heart failure was also the most frequent cause of cardiovascular hospitalization, followed by gastrointestinal problems, infections, and tumours for noncardiovascular hospitalizations. Patients with HFrEF had different baseline characteristics and risk profiles, experienced more hospitalizations for acute heart failure (28.6% vs 20.2%, P=0.012), and had higher cardiovascular mortality (82.4% vs 63.5%, P<0.001) when compared with HFpEF patients. Overall mortality and rehospitalization rates were similar. Conclusion. Within 2 years, half of the patients died and/or were hospitalised for acute decompensation of heart failure, and only one-third of the patients survived without any hospitalization. HFrEF and HFpEF patients were confirmed to be different entities with diverse characteristics, risk profiles, and cardiovascular event rates.

Links

MUNI/A/1250/2017, interní kód MU

Name: Validace Rule-out/rule-in protokolu u pacientů s bolestí na hrudi – pokračování v prospektivní studii

Investor: Masaryk University, Category A

Citovat

MIKLIK, Roman, Marie MIKLÍKOVÁ, Radim SPACEK, Jindřich ŠPINAR, Kamil ZEMAN, Klára BENEŠOVÁ, Marián FELŠÖCI, Lidka POHLUDKOVA, Ladislav DUŠEK, Jiří JARKOVSKÝ, Petr LOKAJ, Ilona PARENICOVA and Jiří PAŘENICA. Differences in risk profiles and long-term outcomes in acute heart failure patients with preserved and reduced left ventricular ejection fraction in the Czech Republic: The AHEAD registry sub-analysis. Biomedical Papers, Olomouc: Palacky University. Olomouc: Palacky University, 2021, vol. 165, No 1, p. 34-42. ISSN 1213-8118. Available from: https://dx.doi.org/10.5507/bp.2020.038.

@article{1786744,
   author = {Miklik, Roman and Miklíková, Marie and Spacek, Radim and Špinar, Jindřich and Zeman, Kamil and Benešová, Klára and Felšöci, Marián and Pohludkova, Lidka and Dušek, Ladislav and Jarkovský, Jiří and Lokaj, Petr and Parenicova, Ilona and Pařenica, Jiří},
   article_location = {Olomouc},
   article_number = {1},
   doi = {http://dx.doi.org/10.5507/bp.2020.038},
   keywords = {acute heart failure; left ventricular ejection fraction; rehospitalization; AHEAD; mortality},
   language = {eng},
   issn = {1213-8118},
   journal = {Biomedical Papers, Olomouc: Palacky University},
   title = {Differences in risk profiles and long-term outcomes in acute heart failure patients with preserved and reduced left ventricular ejection fraction in the Czech Republic: The AHEAD registry sub-analysis},
   url = {https://biomed.papers.upol.cz/artkey/bio-202101-0006_differences-in-risk-profiles-and-long-term-outcomes-in-acute-heart-failure-patients-with-preserved-and-reduced.php},
   volume = {165},
   year = {2021}
}

TY  - JOUR
ID  - 1786744
AU  - Miklik, Roman - Miklíková, Marie - Spacek, Radim - Špinar, Jindřich - Zeman, Kamil - Benešová, Klára - Felšöci, Marián - Pohludkova, Lidka - Dušek, Ladislav - Jarkovský, Jiří - Lokaj, Petr - Parenicova, Ilona - Pařenica, Jiří
PY  - 2021
TI  - Differences in risk profiles and long-term outcomes in acute heart failure patients with preserved and reduced left ventricular ejection fraction in the Czech Republic: The AHEAD registry sub-analysis
JF  - Biomedical Papers, Olomouc: Palacky University
VL  - 165
IS  - 1
SP  - 34-42
EP  - 34-42
PB  - Palacky University
SN  - 12138118
KW  - acute heart failure
KW  - left ventricular ejection fraction
KW  - rehospitalization
KW  - AHEAD
KW  - mortality
UR  - https://biomed.papers.upol.cz/artkey/bio-202101-0006_differences-in-risk-profiles-and-long-term-outcomes-in-acute-heart-failure-patients-with-preserved-and-reduced.php
N2  - Background. The latest European heart failure guidelines define patients as those with reduced (HFrEF), mid-range, and preserved (HFpEF) left ventricular ejection fraction (LVEF; <40%, 40%-49%, and >= 50%, respectively). We investigated the causes of rehospitalizations/deaths in our institution's heart failure patients and focused on differences in the clinical presentation, risk profile, and long-term outcomes between the HFrEF and HFpEF groups in a real-life scenario. Methods and Results. We followed 1274 patients discharged from heart failure hospitalization in 2 centres. The mean patient age was 75.9 years, and men and women were represented equally. During the minimal follow-up of 2 years, 57% of patients were hospitalised for any cause, 24.9% for decompensated heart failure, and 43.3% for any cardiovascular cause. A total of 36.1% of patients died, either with prior (11.8%) or without prior (24.3%) heart failure rehospitalization. Heart failure was also the most frequent cause of cardiovascular hospitalization, followed by gastrointestinal problems, infections, and tumours for noncardiovascular hospitalizations. Patients with HFrEF had different baseline characteristics and risk profiles, experienced more hospitalizations for acute heart failure (28.6% vs 20.2%, P=0.012), and had higher cardiovascular mortality (82.4% vs 63.5%, P<0.001) when compared with HFpEF patients. Overall mortality and rehospitalization rates were similar. Conclusion. Within 2 years, half of the patients died and/or were hospitalised for acute decompensation of heart failure, and only one-third of the patients survived without any hospitalization. HFrEF and HFpEF patients were confirmed to be different entities with diverse characteristics, risk profiles, and cardiovascular event rates.
ER  -

MIKLIK, Roman, Marie MIKLÍKOVÁ, Radim SPACEK, Jindřich ŠPINAR, Kamil ZEMAN, Klára BENEŠOVÁ, Marián FELŠÖCI, Lidka POHLUDKOVA, Ladislav DUŠEK, Jiří JARKOVSKÝ, Petr LOKAJ, Ilona PARENICOVA and Jiří PAŘENICA. Differences in risk profiles and long-term outcomes in acute heart failure patients with preserved and reduced left ventricular ejection fraction in the Czech Republic: The AHEAD registry sub-analysis. \textit{Biomedical Papers, Olomouc: Palacky University}. Olomouc: Palacky University, 2021, vol.~165, No~1, p.~34-42. ISSN~1213-8118. Available from: https://dx.doi.org/10.5507/bp.2020.038.

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