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@article{1786781,
author = {Dompe, C. and Kulus, M. and Stefanska, K. and Kranc, W. and Chermula, B. and Bryl, R. and Pienkowski, W. and Nawrocki, M. J. and Petitte, J. N. and Stelmach, B. and Mozdziak, P. and Ješeta, Michal and Pawelczyk, L. and Jaskowski, J. M. and PiotrowskaandKempisty, H. and Spaczynski, R. Z. and Nowicki, M. and Kempisty, B.},
article_location = {Basel},
article_number = {6},
doi = {http://dx.doi.org/10.3390/cells10061396},
keywords = {stem cells; granulosa cells; cumulus cells; translational medicine; miRNA; follicular angiogenesis},
language = {eng},
issn = {2073-4409},
journal = {Cells},
title = {Human Granulosa Cells-Stemness Properties, Molecular Cross-Talk and Follicular Angiogenesis},
url = {https://www.mdpi.com/2073-4409/10/6/1396},
volume = {10},
year = {2021}
}
TY - JOUR
ID - 1786781
AU - Dompe, C. - Kulus, M. - Stefanska, K. - Kranc, W. - Chermula, B. - Bryl, R. - Pienkowski, W. - Nawrocki, M. J. - Petitte, J. N. - Stelmach, B. - Mozdziak, P. - Ješeta, Michal - Pawelczyk, L. - Jaskowski, J. M. - Piotrowska-Kempisty, H. - Spaczynski, R. Z. - Nowicki, M. - Kempisty, B.
PY - 2021
TI - Human Granulosa Cells-Stemness Properties, Molecular Cross-Talk and Follicular Angiogenesis
JF - Cells
VL - 10
IS - 6
SP - 1-23
EP - 1-23
PB - MDPI
SN - 20734409
KW - stem cells
KW - granulosa cells
KW - cumulus cells
KW - translational medicine
KW - miRNA
KW - follicular angiogenesis
UR - https://www.mdpi.com/2073-4409/10/6/1396
N2 - The ovarian follicle is the basic functional unit of the ovary, comprising theca cells and granulosa cells (GCs). Two different types of GCs, mural GCs and cumulus cells (CCs), serve different functions during folliculogenesis. Mural GCs produce oestrogen during the follicular phase and progesterone after ovulation, while CCs surround the oocyte tightly and form the cumulus oophurus and corona radiata inner cell layer. CCs are also engaged in bi-directional metabolite exchange with the oocyte, as they form gap-junctions, which are crucial for both the oocyte's proper maturation and GC proliferation. However, the function of both GCs and CCs is dependent on proper follicular angiogenesis. Aside from participating in complex molecular interplay with the oocyte, the ovarian follicular cells exhibit stem-like properties, characteristic of mesenchymal stem cells (MSCs). Both GCs and CCs remain under the influence of various miRNAs, and some of them may contribute to polycystic ovary syndrome (PCOS) or premature ovarian insufficiency (POI) occurrence. Considering increasing female fertility problems worldwide, it is of interest to develop new strategies enhancing assisted reproductive techniques. Therefore, it is important to carefully consider GCs as ovarian stem cells in terms of the cellular features and molecular pathways involved in their development and interactions as well as outline their possible application in translational medicine.
ER -
DOMPE, C., M. KULUS, K. STEFANSKA, W. KRANC, B. CHERMULA, R. BRYL, W. PIENKOWSKI, M. J. NAWROCKI, J. N. PETITTE, B. STELMACH, P. MOZDZIAK, Michal JEŠETA, L. PAWELCZYK, J. M. JASKOWSKI, H. PIOTROWSKA-KEMPISTY, R. Z. SPACZYNSKI, M. NOWICKI and B. KEMPISTY. Human Granulosa Cells-Stemness Properties, Molecular Cross-Talk and Follicular Angiogenesis. \textit{Cells}. Basel: MDPI, 2021, vol.~10, No~6, p.~1-23. ISSN~2073-4409. Available from: https://dx.doi.org/10.3390/cells10061396.
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