The Clinical Significance of DJ1 and L1CAM Serum Level
Monitoring in Patients with Endometrial Cancer

J 2021

The Clinical Significance of DJ1 and L1CAM Serum Level Monitoring in Patients with Endometrial Cancer

BEDNAŘÍKOVÁ, Markéta, Petra VINKLEROVÁ, Jana GOTTWALDOVÁ, Petra OVESNÁ, Jitka HAUSNEROVÁ et. al.

Basic information

Original name

The Clinical Significance of DJ1 and L1CAM Serum Level Monitoring in Patients with Endometrial Cancer

Authors

BEDNAŘÍKOVÁ, Markéta (203 Czech Republic, belonging to the institution), Petra VINKLEROVÁ (203 Czech Republic, belonging to the institution), Jana GOTTWALDOVÁ (203 Czech Republic, belonging to the institution), Petra OVESNÁ (203 Czech Republic, belonging to the institution), Jitka HAUSNEROVÁ (203 Czech Republic, belonging to the institution), Luboš MINÁŘ (203 Czech Republic, belonging to the institution), Michal FELSINGER (203 Czech Republic, belonging to the institution), Dalibor VALÍK (203 Czech Republic, belonging to the institution), Zdeňka ČERMÁKOVÁ (203 Czech Republic, belonging to the institution) and Vít WEINBERGER (203 Czech Republic, guarantor, belonging to the institution)

Edition

Journal of Clinical Medicine, Basel, MDPI, 2021, 2077-0383

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30218 General and internal medicine

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.964

RIV identification code

RIV/00216224:14110/21:00122136

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3390/jcm10122640

UT WoS

000666157800001

Keywords in English

tumor markers; endometrial cancer; DJ1; L1CAM

Abstract

V originále

Circulating tumor markers are not routinely used in patients with endometrial cancer (EC). This pilot study evaluated the role of monitoring new biomarkers DJ1 and L1CAM, in correlation with CA125 and HE4, for the effects of anticancer treatment and preoperative management in EC patients. Serial serum levels of DJ1, L1CAM, CA125 and HE4 were collected in 65 enrolled patients. Serum DJ1, L1CAM, CA125 and HE4 levels were significantly higher at the time of diagnosis compared to those measured during follow-up (FU). In patients with recurrent disease, serum DJ1, CA125 and HE4 levels were significantly higher at the time of recurrence compared to levels in disease-free patients. Serum L1CAM levels were also higher in patients with recurrence but without reaching statistical significance. While DJ1 levels were not affected by any of the observed patient-related characteristics, L1CAM levels were significantly higher in patients with age >= 60 years who were overweight. At the time of EC diagnosis, DJ1 and L1CAM serum levels did not correlate with stage, histological type or risk of recurrence. This is a preliminary description of the potential of serial DJ1 and L1CAM serum level measurement for monitoring the effects of treatment in EC patients.

Citovat

BEDNAŘÍKOVÁ, Markéta, Petra VINKLEROVÁ, Jana GOTTWALDOVÁ, Petra OVESNÁ, Jitka HAUSNEROVÁ, Luboš MINÁŘ, Michal FELSINGER, Dalibor VALÍK, Zdeňka ČERMÁKOVÁ and Vít WEINBERGER. The Clinical Significance of DJ1 and L1CAM Serum Level Monitoring in Patients with Endometrial Cancer. Journal of Clinical Medicine. Basel: MDPI, 2021, vol. 10, No 12, p. 1-14. ISSN 2077-0383. Available from: https://dx.doi.org/10.3390/jcm10122640.

@article{1786894,
   author = {Bednaříková, Markéta and Vinklerová, Petra and Gottwaldová, Jana and Ovesná, Petra and Hausnerová, Jitka and Minář, Luboš and Felsinger, Michal and Valík, Dalibor and Čermáková, Zdeňka and Weinberger, Vít},
   article_location = {Basel},
   article_number = {12},
   doi = {http://dx.doi.org/10.3390/jcm10122640},
   keywords = {tumor markers; endometrial cancer; DJ1; L1CAM},
   language = {eng},
   issn = {2077-0383},
   journal = {Journal of Clinical Medicine},
   title = {The Clinical Significance of DJ1 and L1CAM Serum Level Monitoring in Patients with Endometrial Cancer},
   url = {https://www.mdpi.com/2077-0383/10/12/2640},
   volume = {10},
   year = {2021}
}

TY  - JOUR
ID  - 1786894
AU  - Bednaříková, Markéta - Vinklerová, Petra - Gottwaldová, Jana - Ovesná, Petra - Hausnerová, Jitka - Minář, Luboš - Felsinger, Michal - Valík, Dalibor - Čermáková, Zdeňka - Weinberger, Vít
PY  - 2021
TI  - The Clinical Significance of DJ1 and L1CAM Serum Level Monitoring in Patients with Endometrial Cancer
JF  - Journal of Clinical Medicine
VL  - 10
IS  - 12
SP  - 1-14
EP  - 1-14
PB  - MDPI
SN  - 20770383
KW  - tumor markers
KW  - endometrial cancer
KW  - DJ1
KW  - L1CAM
UR  - https://www.mdpi.com/2077-0383/10/12/2640
N2  - Circulating tumor markers are not routinely used in patients with endometrial cancer (EC). This pilot study evaluated the role of monitoring new biomarkers DJ1 and L1CAM, in correlation with CA125 and HE4, for the effects of anticancer treatment and preoperative management in EC patients. Serial serum levels of DJ1, L1CAM, CA125 and HE4 were collected in 65 enrolled patients. Serum DJ1, L1CAM, CA125 and HE4 levels were significantly higher at the time of diagnosis compared to those measured during follow-up (FU). In patients with recurrent disease, serum DJ1, CA125 and HE4 levels were significantly higher at the time of recurrence compared to levels in disease-free patients. Serum L1CAM levels were also higher in patients with recurrence but without reaching statistical significance. While DJ1 levels were not affected by any of the observed patient-related characteristics, L1CAM levels were significantly higher in patients with age >= 60 years who were overweight. At the time of EC diagnosis, DJ1 and L1CAM serum levels did not correlate with stage, histological type or risk of recurrence. This is a preliminary description of the potential of serial DJ1 and L1CAM serum level measurement for monitoring the effects of treatment in EC patients.
ER  -

BEDNAŘÍKOVÁ, Markéta, Petra VINKLEROVÁ, Jana GOTTWALDOVÁ, Petra OVESNÁ, Jitka HAUSNEROVÁ, Luboš MINÁŘ, Michal FELSINGER, Dalibor VALÍK, Zdeňka ČERMÁKOVÁ and Vít WEINBERGER. The Clinical Significance of DJ1 and L1CAM Serum Level Monitoring in Patients with Endometrial Cancer. \textit{Journal of Clinical Medicine}. Basel: MDPI, 2021, vol.~10, No~12, p.~1-14. ISSN~2077-0383. Available from: https://dx.doi.org/10.3390/jcm10122640.

Detailed Information on Publication Record