Prognostic significance of lymphocyte patterns in multiple
myeloma patients after autologous transplant

J 2021

Prognostic significance of lymphocyte patterns in multiple myeloma patients after autologous transplant

ŠTORK, Martin, Renata BEZDĚKOVÁ, Romana KRÁLOVÁ, Viera SANDECKÁ, Zdeněk ADAM et. al.

Basic information

Original name

Prognostic significance of lymphocyte patterns in multiple myeloma patients after autologous transplant

Authors

ŠTORK, Martin (203 Czech Republic), Renata BEZDĚKOVÁ (203 Czech Republic), Romana KRÁLOVÁ (203 Czech Republic), Viera SANDECKÁ (703 Slovakia, guarantor), Zdeněk ADAM (203 Czech Republic), Marta KREJČÍ (203 Czech Republic), Ivanna BOICHUK (804 Ukraine), Zdeňka KNECHTOVÁ (203 Czech Republic), Lucie BROŽOVÁ (203 Czech Republic), Sabina ŠEVČÍKOVÁ (203 Czech Republic, belonging to the institution), Lucie ŘÍHOVÁ (203 Czech Republic) and Luděk POUR (203 Czech Republic)

Edition

Neoplasma, Bratislava, Slovenská akademie vied, 2021, 0028-2685

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

Slovakia

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.409

RIV identification code

RIV/00216224:14110/21:00120121

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.4149/neo_2021_200814N861

UT WoS

000662144000007

Keywords in English

multiple myeloma; minimal residual disease; lymphocyte; flow cytometry

Abstract

V originále

Despite the high efficacy of current induction regimens, most multiple myeloma (MM) patients relapse over time. The link between changes in the immune system and the prognosis of the disease is still not entirely clear. Therefore, we analyzed whether the pattern of bone marrow (BM) lymphocytes during routine BM examination after autologous stem cell transplant (ASCT) is related to disease prognosis or MRD negative complete remission. From 2009 to 2018, 98 MM patients underwent routine BM testing after the first ASCT. Using multi-parametric flow cytometry, twelve BM lymphocyte subtypes were analyzed. In 60% of patients who achieved a complete response (CR), MRD by flow cytometric analysis (sensitivity threshold 10-6) was evaluated. We found an association of relative proportion of BM lymphocyte subtypes with treatment response, progression-free survival (PFS), overall survival (OS), and minimal residual disease (MRD) negativity. Higher relative proportion of memory B cells was associated with inferior median PFS [HR 1.089 (95% CI: 1.023-1.160), p=0.0081 and median OS [HR 1.170 (95% CI: 1.074-1.274), p<0.001]. In non-responding patients (minimal response and worse), higher proportion of memory B cells was found when compared to patients achieving CR [3.8% (range 0.5-35.0) vs. 1.0% (range 0.1-12.5); p=0.0011. No significant association of BM lymphocyte subtypes proportion with MRD negative CR was found. Our results show that changes in BM lymphocyte subsets including memory B cells may have prognostic value in MM patients after ASCT.

Links

NV17-29343A, research and development project

Name: Analýza mikroprostředí kostní dřeně u extramedulárního relapsu mnohočetného myelomu

Citovat

ŠTORK, Martin, Renata BEZDĚKOVÁ, Romana KRÁLOVÁ, Viera SANDECKÁ, Zdeněk ADAM, Marta KREJČÍ, Ivanna BOICHUK, Zdeňka KNECHTOVÁ, Lucie BROŽOVÁ, Sabina ŠEVČÍKOVÁ, Lucie ŘÍHOVÁ and Luděk POUR. Prognostic significance of lymphocyte patterns in multiple myeloma patients after autologous transplant. Neoplasma. Bratislava: Slovenská akademie vied, 2021, vol. 68, No 3, p. 519-527. ISSN 0028-2685. Available from: https://dx.doi.org/10.4149/neo_2021_200814N861.

@article{1787323,
   author = {Štork, Martin and Bezděková, Renata and Králová, Romana and Sandecká, Viera and Adam, Zdeněk and Krejčí, Marta and Boichuk, Ivanna and Knechtová, Zdeňka and Brožová, Lucie and Ševčíková, Sabina and Říhová, Lucie and Pour, Luděk},
   article_location = {Bratislava},
   article_number = {3},
   doi = {http://dx.doi.org/10.4149/neo_2021_200814N861},
   keywords = {multiple myeloma; minimal residual disease; lymphocyte; flow cytometry},
   language = {eng},
   issn = {0028-2685},
   journal = {Neoplasma},
   title = {Prognostic significance of lymphocyte patterns in multiple myeloma patients after autologous transplant},
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   volume = {68},
   year = {2021}
}

TY  - JOUR
ID  - 1787323
AU  - Štork, Martin - Bezděková, Renata - Králová, Romana - Sandecká, Viera - Adam, Zdeněk - Krejčí, Marta - Boichuk, Ivanna - Knechtová, Zdeňka - Brožová, Lucie - Ševčíková, Sabina - Říhová, Lucie - Pour, Luděk
PY  - 2021
TI  - Prognostic significance of lymphocyte patterns in multiple myeloma patients after autologous transplant
JF  - Neoplasma
VL  - 68
IS  - 3
SP  - 519-527
EP  - 519-527
PB  - Slovenská akademie vied
SN  - 00282685
KW  - multiple myeloma
KW  - minimal residual disease
KW  - lymphocyte
KW  - flow cytometry
UR  - http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=7126&category_id=172&option=com_virtuemart&vmcchk=1&Itemid=1
N2  - Despite the high efficacy of current induction regimens, most multiple myeloma (MM) patients relapse over time. The link between changes in the immune system and the prognosis of the disease is still not entirely clear. Therefore, we analyzed whether the pattern of bone marrow (BM) lymphocytes during routine BM examination after autologous stem cell transplant (ASCT) is related to disease prognosis or MRD negative complete remission. From 2009 to 2018, 98 MM patients underwent routine BM testing after the first ASCT. Using multi-parametric flow cytometry, twelve BM lymphocyte subtypes were analyzed. In 60% of patients who achieved a complete response (CR), MRD by flow cytometric analysis (sensitivity threshold 10-6) was evaluated. We found an association of relative proportion of BM lymphocyte subtypes with treatment response, progression-free survival (PFS), overall survival (OS), and minimal residual disease (MRD) negativity. Higher relative proportion of memory B cells was associated with inferior median PFS [HR 1.089 (95% CI: 1.023-1.160), p=0.0081 and median OS [HR 1.170 (95% CI: 1.074-1.274), p<0.001]. In non-responding patients (minimal response and worse), higher proportion of memory B cells was found when compared to patients achieving CR [3.8% (range 0.5-35.0) vs. 1.0% (range 0.1-12.5); p=0.0011. No significant association of BM lymphocyte subtypes proportion with MRD negative CR was found. Our results show that changes in BM lymphocyte subsets including memory B cells may have prognostic value in MM patients after ASCT.
ER  -

ŠTORK, Martin, Renata BEZDĚKOVÁ, Romana KRÁLOVÁ, Viera SANDECKÁ, Zdeněk ADAM, Marta KREJČÍ, Ivanna BOICHUK, Zdeňka KNECHTOVÁ, Lucie BROŽOVÁ, Sabina ŠEVČÍKOVÁ, Lucie ŘÍHOVÁ and Luděk POUR. Prognostic significance of lymphocyte patterns in multiple myeloma patients after autologous transplant. \textit{Neoplasma}. Bratislava: Slovenská akademie vied, 2021, vol.~68, No~3, p.~519-527. ISSN~0028-2685. Available from: https://dx.doi.org/10.4149/neo\_{}2021\_{}200814N861.

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