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@article{1787323,
author = {Štork, Martin and Bezděková, Renata and Králová, Romana and Sandecká, Viera and Adam, Zdeněk and Krejčí, Marta and Boichuk, Ivanna and Knechtová, Zdeňka and Brožová, Lucie and Ševčíková, Sabina and Říhová, Lucie and Pour, Luděk},
article_location = {Bratislava},
article_number = {3},
doi = {http://dx.doi.org/10.4149/neo_2021_200814N861},
keywords = {multiple myeloma; minimal residual disease; lymphocyte; flow cytometry},
language = {eng},
issn = {0028-2685},
journal = {Neoplasma},
title = {Prognostic significance of lymphocyte patterns in multiple myeloma patients after autologous transplant},
url = {http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=7126&category_id=172&option=com_virtuemart&vmcchk=1&Itemid=1},
volume = {68},
year = {2021}
}
TY - JOUR
ID - 1787323
AU - Štork, Martin - Bezděková, Renata - Králová, Romana - Sandecká, Viera - Adam, Zdeněk - Krejčí, Marta - Boichuk, Ivanna - Knechtová, Zdeňka - Brožová, Lucie - Ševčíková, Sabina - Říhová, Lucie - Pour, Luděk
PY - 2021
TI - Prognostic significance of lymphocyte patterns in multiple myeloma patients after autologous transplant
JF - Neoplasma
VL - 68
IS - 3
SP - 519-527
EP - 519-527
PB - Slovenská akademie vied
SN - 00282685
KW - multiple myeloma
KW - minimal residual disease
KW - lymphocyte
KW - flow cytometry
UR - http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=7126&category_id=172&option=com_virtuemart&vmcchk=1&Itemid=1
N2 - Despite the high efficacy of current induction regimens, most multiple myeloma (MM) patients relapse over time. The link between changes in the immune system and the prognosis of the disease is still not entirely clear. Therefore, we analyzed whether the pattern of bone marrow (BM) lymphocytes during routine BM examination after autologous stem cell transplant (ASCT) is related to disease prognosis or MRD negative complete remission. From 2009 to 2018, 98 MM patients underwent routine BM testing after the first ASCT. Using multi-parametric flow cytometry, twelve BM lymphocyte subtypes were analyzed. In 60% of patients who achieved a complete response (CR), MRD by flow cytometric analysis (sensitivity threshold 10-6) was evaluated. We found an association of relative proportion of BM lymphocyte subtypes with treatment response, progression-free survival (PFS), overall survival (OS), and minimal residual disease (MRD) negativity. Higher relative proportion of memory B cells was associated with inferior median PFS [HR 1.089 (95% CI: 1.023-1.160), p=0.0081 and median OS [HR 1.170 (95% CI: 1.074-1.274), p<0.001]. In non-responding patients (minimal response and worse), higher proportion of memory B cells was found when compared to patients achieving CR [3.8% (range 0.5-35.0) vs. 1.0% (range 0.1-12.5); p=0.0011. No significant association of BM lymphocyte subtypes proportion with MRD negative CR was found. Our results show that changes in BM lymphocyte subsets including memory B cells may have prognostic value in MM patients after ASCT.
ER -
ŠTORK, Martin, Renata BEZDĚKOVÁ, Romana KRÁLOVÁ, Viera SANDECKÁ, Zdeněk ADAM, Marta KREJČÍ, Ivanna BOICHUK, Zdeňka KNECHTOVÁ, Lucie BROŽOVÁ, Sabina ŠEVČÍKOVÁ, Lucie ŘÍHOVÁ and Luděk POUR. Prognostic significance of lymphocyte patterns in multiple myeloma patients after autologous transplant. \textit{Neoplasma}. Bratislava: Slovenská akademie vied, 2021, vol.~68, No~3, p.~519-527. ISSN~0028-2685. Available from: https://dx.doi.org/10.4149/neo\_{}2021\_{}200814N861.
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