Development of a New Risk Score for Stratification of Women
with Gestational Diabetes Mellitus at High Risk of Persisting
Postpartum Glucose Intolerance Using Routinely Assessed
Parameters

J 2021

Development of a New Risk Score for Stratification of Women with Gestational Diabetes Mellitus at High Risk of Persisting Postpartum Glucose Intolerance Using Routinely Assessed Parameters

BARTÁKOVÁ, Vendula, Beáta BARÁTOVÁ, Lukáš PÁCAL, Veronika ŤÁPALOVÁ, Silvie SEBESTOVA et. al.

Basic information

Original name

Development of a New Risk Score for Stratification of Women with Gestational Diabetes Mellitus at High Risk of Persisting Postpartum Glucose Intolerance Using Routinely Assessed Parameters

Authors

BARTÁKOVÁ, Vendula (203 Czech Republic, guarantor, belonging to the institution), Beáta BARÁTOVÁ (703 Slovakia, belonging to the institution), Lukáš PÁCAL (203 Czech Republic, belonging to the institution), Veronika ŤÁPALOVÁ (203 Czech Republic), Silvie SEBESTOVA (203 Czech Republic), Petr JANKŮ (203 Czech Republic, belonging to the institution) and Kateřina KAŇKOVÁ (203 Czech Republic, belonging to the institution)

Edition

LIFE-BASEL, BASEL, MDPI, 2021, 2075-1729

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10606 Microbiology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.253

RIV identification code

RIV/00216224:14110/21:00120124

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3390/life11060464

UT WoS

000666427900001

Keywords in English

gestational diabetes mellitus; persisting glucose intolerance postpartum; risk score; peripartal outcomes

Abstract

V originále

The aims of the study were (i) to find predictive factors for early postpartum conversion of gestational diabetes mellitus (GDM) into persisting glucose intolerance (PGI), (ii) to evaluate potential differences in adverse perinatal outcomes in GDM women with and without early postpartum PGI and, finally, (iii) to establish a risk score to predict postpartum PGI. A cross-sectional study comprised 244 GDM patients with known age, parity, positive family history of diabetes, pre-gestational BMI, comorbidities, smoking history, results of mid-trimester oral glucose tolerance test, HbA1c, obstetric complications, neonatal outcomes and mode of delivery. A risk score was calculated using parameters with highest odds ratios in a statistic scoring model. Significant differences between women with and without PGI postpartum were ascertained for mid-trimester fasting plasma glucose (p < 0.001), HbA1c above 42 mmol/mol (p = 0.035), prevalence of obesity (p = 0.007), hypothyroidism, family history of diabetes and smoking. We also observed higher incidence of prolonged and complicated delivery in PGI group (p = 0.04 and 0.007, respectively). In conclusion, this study identified several parameters with predictive potential for early PGI and also adverse peripartal outcomes. We established a simple risk-stratification score for PGI prediction applicable for GDM affected women prior their leaving maternity ward. Yet, given a relatively small sample size as a main limitation of this study, the proposed score should be validated in the larger cohort.

Links

NV18-01-00046, research and development project

Name: Genetické skóre v predikci rizika diabetu a jeho komplikací

Investor: Ministry of Health of the CR

Citovat

BARTÁKOVÁ, Vendula, Beáta BARÁTOVÁ, Lukáš PÁCAL, Veronika ŤÁPALOVÁ, Silvie SEBESTOVA, Petr JANKŮ and Kateřina KAŇKOVÁ. Development of a New Risk Score for Stratification of Women with Gestational Diabetes Mellitus at High Risk of Persisting Postpartum Glucose Intolerance Using Routinely Assessed Parameters. LIFE-BASEL. BASEL: MDPI, 2021, vol. 11, No 6, p. 1-10. ISSN 2075-1729. Available from: https://dx.doi.org/10.3390/life11060464.

@article{1787357,
   author = {Bartáková, Vendula and Barátová, Beáta and Pácal, Lukáš and Ťápalová, Veronika and Sebestova, Silvie and Janků, Petr and Kaňková, Kateřina},
   article_location = {BASEL},
   article_number = {6},
   doi = {http://dx.doi.org/10.3390/life11060464},
   keywords = {gestational diabetes mellitus; persisting glucose intolerance postpartum; risk score; peripartal outcomes},
   language = {eng},
   issn = {2075-1729},
   journal = {LIFE-BASEL},
   title = {Development of a New Risk Score for Stratification of Women with Gestational Diabetes Mellitus at High Risk of Persisting Postpartum Glucose Intolerance Using Routinely Assessed Parameters},
   url = {https://www.mdpi.com/2075-1729/11/6/464},
   volume = {11},
   year = {2021}
}

TY  - JOUR
ID  - 1787357
AU  - Bartáková, Vendula - Barátová, Beáta - Pácal, Lukáš - Ťápalová, Veronika - Sebestova, Silvie - Janků, Petr - Kaňková, Kateřina
PY  - 2021
TI  - Development of a New Risk Score for Stratification of Women with Gestational Diabetes Mellitus at High Risk of Persisting Postpartum Glucose Intolerance Using Routinely Assessed Parameters
JF  - LIFE-BASEL
VL  - 11
IS  - 6
SP  - 1-10
EP  - 1-10
PB  - MDPI
SN  - 20751729
KW  - gestational diabetes mellitus
KW  - persisting glucose intolerance postpartum
KW  - risk score
KW  - peripartal outcomes
UR  - https://www.mdpi.com/2075-1729/11/6/464
N2  - The aims of the study were (i) to find predictive factors for early postpartum conversion of gestational diabetes mellitus (GDM) into persisting glucose intolerance (PGI), (ii) to evaluate potential differences in adverse perinatal outcomes in GDM women with and without early postpartum PGI and, finally, (iii) to establish a risk score to predict postpartum PGI. A cross-sectional study comprised 244 GDM patients with known age, parity, positive family history of diabetes, pre-gestational BMI, comorbidities, smoking history, results of mid-trimester oral glucose tolerance test, HbA1c, obstetric complications, neonatal outcomes and mode of delivery. A risk score was calculated using parameters with highest odds ratios in a statistic scoring model. Significant differences between women with and without PGI postpartum were ascertained for mid-trimester fasting plasma glucose (p < 0.001), HbA1c above 42 mmol/mol (p = 0.035), prevalence of obesity (p = 0.007), hypothyroidism, family history of diabetes and smoking. We also observed higher incidence of prolonged and complicated delivery in PGI group (p = 0.04 and 0.007, respectively). In conclusion, this study identified several parameters with predictive potential for early PGI and also adverse peripartal outcomes. We established a simple risk-stratification score for PGI prediction applicable for GDM affected women prior their leaving maternity ward. Yet, given a relatively small sample size as a main limitation of this study, the proposed score should be validated in the larger cohort.
ER  -

BARTÁKOVÁ, Vendula, Beáta BARÁTOVÁ, Lukáš PÁCAL, Veronika ŤÁPALOVÁ, Silvie SEBESTOVA, Petr JANKŮ and Kateřina KAŇKOVÁ. Development of a New Risk Score for Stratification of Women with Gestational Diabetes Mellitus at High Risk of Persisting Postpartum Glucose Intolerance Using Routinely Assessed Parameters. \textit{LIFE-BASEL}. BASEL: MDPI, 2021, vol.~11, No~6, p.~1-10. ISSN~2075-1729. Available from: https://dx.doi.org/10.3390/life11060464.

Detailed Information on Publication Record