Development of a New Risk Score for Stratification of Women with Gestational Diabetes Mellitus at High Risk of Persisting Postpartum Glucose Intolerance Using Routinely Assessed Parameters

BARTÁKOVÁ, Vendula, Beáta BARÁTOVÁ, Lukáš PÁCAL, Veronika ŤÁPALOVÁ, Silvie SEBESTOVA, Petr JANKŮ and Kateřina KAŇKOVÁ. Development of a New Risk Score for Stratification of Women with Gestational Diabetes Mellitus at High Risk of Persisting Postpartum Glucose Intolerance Using Routinely Assessed Parameters. LIFE-BASEL. BASEL: MDPI, 2021, vol. 11, No 6, p. 1-10. ISSN 2075-1729. Available from: https://dx.doi.org/10.3390/life11060464.

Basic information

• Original name: Development of a New Risk Score for Stratification of Women with Gestational Diabetes Mellitus at High Risk of Persisting Postpartum Glucose Intolerance Using Routinely Assessed Parameters
• Authors: BARTÁKOVÁ, Vendula (203 Czech Republic, guarantor, belonging to the institution), Beáta BARÁTOVÁ (703 Slovakia, belonging to the institution), Lukáš PÁCAL (203 Czech Republic, belonging to the institution), Veronika ŤÁPALOVÁ (203 Czech Republic), Silvie SEBESTOVA (203 Czech Republic), Petr JANKŮ (203 Czech Republic, belonging to the institution) and Kateřina KAŇKOVÁ (203 Czech Republic, belonging to the institution).
• Edition: LIFE-BASEL, BASEL, MDPI, 2021, 2075-1729.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 10606 Microbiology
• Country of publisher: Switzerland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 3.253
• RIV identification code: RIV/00216224:14110/21:00120124
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.3390/life11060464
• UT WoS: 000666427900001
• Keywords in English: gestational diabetes mellitus; persisting glucose intolerance postpartum; risk score; peripartal outcomes
• Tags: 14110518, 14110611, rivok
• Tags: International impact, Reviewed

Abstract

The aims of the study were (i) to find predictive factors for early postpartum conversion of gestational diabetes mellitus (GDM) into persisting glucose intolerance (PGI), (ii) to evaluate potential differences in adverse perinatal outcomes in GDM women with and without early postpartum PGI and, finally, (iii) to establish a risk score to predict postpartum PGI. A cross-sectional study comprised 244 GDM patients with known age, parity, positive family history of diabetes, pre-gestational BMI, comorbidities, smoking history, results of mid-trimester oral glucose tolerance test, HbA1c, obstetric complications, neonatal outcomes and mode of delivery. A risk score was calculated using parameters with highest odds ratios in a statistic scoring model. Significant differences between women with and without PGI postpartum were ascertained for mid-trimester fasting plasma glucose (p < 0.001), HbA1c above 42 mmol/mol (p = 0.035), prevalence of obesity (p = 0.007), hypothyroidism, family history of diabetes and smoking. We also observed higher incidence of prolonged and complicated delivery in PGI group (p = 0.04 and 0.007, respectively). In conclusion, this study identified several parameters with predictive potential for early PGI and also adverse peripartal outcomes. We established a simple risk-stratification score for PGI prediction applicable for GDM affected women prior their leaving maternity ward. Yet, given a relatively small sample size as a main limitation of this study, the proposed score should be validated in the larger cohort.

Links

• NV18-01-00046, research and development project: Name: Genetické skóre v predikci rizika diabetu a jeho komplikací

Investor: Ministry of Health of the CR