Detailed Information on Publication Record
2020
C-peptide affects glyoxalase 1 level in proximal tubular cells in vitro
KROČKA, Erik, David GALUŠKA, Katarína CHALÁSOVÁ, Lukáš PÁCAL, Kateřina KAŇKOVÁ et. al.Basic information
Original name
C-peptide affects glyoxalase 1 level in proximal tubular cells in vitro
Authors
KROČKA, Erik (703 Slovakia, belonging to the institution), David GALUŠKA (203 Czech Republic, belonging to the institution), Katarína CHALÁSOVÁ (703 Slovakia, belonging to the institution), Lukáš PÁCAL (203 Czech Republic, belonging to the institution) and Kateřina KAŇKOVÁ (203 Czech Republic, belonging to the institution)
Edition
56th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), 2020
Other information
Language
English
Type of outcome
Konferenční abstrakt
Field of Study
30202 Endocrinology and metabolism
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 10.122
RIV identification code
RIV/00216224:14110/20:00120126
Organization unit
Faculty of Medicine
ISSN
UT WoS
000565776600810
Keywords in English
C-peptide; glyoxalase 1 level; proximal tubular cells; in vitro
Tags
Změněno: 23/8/2021 13:01, Mgr. Tereza Miškechová
Abstract
V originále
Diabetic kidney disease (DKD) is the most common cause of end-stage renal disease. Therapeutic strategy to prevent DKD progression involves compensation of diabetes and control of blood pressure, lipids and other metabolic parameters. However, even strict control does not have to be efficient enough. Glyoxalase system with enzyme glyoxalase I (GLO-1) is considered a protective pathway as it eliminates reactive aldehyde methylglyoxal that is involved in the development of DKD. C-peptide which has been long considered as an inert molecule, gained attention recently as it shows favourable effect on molecular and organ level in diabetes. It was shown to increase activity and expression of several antioxidants and it improved renal parameters in animal experiments. The aim of the in vitro experiment was to study the effect of C-peptide on GLO-1.
Links
| NV18-01-00046, research and development project |
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