Pathophysiological Implication of Vitamin D in Diabetic Kidney
Disease

J 2021

Pathophysiological Implication of Vitamin D in Diabetic Kidney Disease

GALUŠKA, David, Lukáš PÁCAL and Kateřina KAŇKOVÁ

Basic information

Original name

Pathophysiological Implication of Vitamin D in Diabetic Kidney Disease

Authors

GALUŠKA, David (203 Czech Republic, belonging to the institution), Lukáš PÁCAL (203 Czech Republic, belonging to the institution) and Kateřina KAŇKOVÁ (203 Czech Republic, belonging to the institution)

Edition

KIDNEY & BLOOD PRESSURE RESEARCH, BASEL, KARGER, 2021, 1420-4096

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30105 Physiology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.096

RIV identification code

RIV/00216224:14110/21:00120127

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1159/000514286

UT WoS

000632543100001

Keywords in English

Diabetes mellitus; Vitamin D; Diabetic kidney disease; Sodium-glucose linked co-transporter 2 inhibitors

Abstract

V originále

Background: Vitamin D is a hormone regulating not only calcium and phosphate homeostasis but also, at the same time, exerting many other extraskeletal functions via genomic effects (gene transcription) and probably by non-genomic effects as well. Availability is ensured by dietary intake of its precursors and by de novo production via sunlight. Yet, vitamin D deficiency and insufficiency are very common across the globe and are connected to many pathophysiological states, for example, diabetes mellitus, allergies, autoimmune diseases, pregnancy complications, and recently have also been associated with worse COVID-19 clinical outcomes. Summary: In this review, we summarize current knowledge about vitamin D metabolism in general, its role in diabetes mellitus (mainly type 2) and diabetic complications (mainly diabetic kidney disease), and potential therapeutic perspectives including vitamin D signalling as a druggable target. Key Messages: Vitamin D is not only a vitamin but also a hormone involved in many physiological processes. Its insufficiency or deficiency can lead to many pathological states.

Links

MUNI/A/1698/2020, interní kód MU

Name: Od molekulární, buněčné a tkáňové k systémové patofyziologii vybraných komplexních nemocí (Acronym: ComplexPF)

Investor: Masaryk University

NV18-01-00046, research and development project

Name: Genetické skóre v predikci rizika diabetu a jeho komplikací

Investor: Ministry of Health of the CR

Citovat

GALUŠKA, David, Lukáš PÁCAL and Kateřina KAŇKOVÁ. Pathophysiological Implication of Vitamin D in Diabetic Kidney Disease. KIDNEY & BLOOD PRESSURE RESEARCH. BASEL: KARGER, 2021, vol. 46, No 2, p. 152-161. ISSN 1420-4096. Available from: https://dx.doi.org/10.1159/000514286.

@article{1787361,
   author = {Galuška, David and Pácal, Lukáš and Kaňková, Kateřina},
   article_location = {BASEL},
   article_number = {2},
   doi = {http://dx.doi.org/10.1159/000514286},
   keywords = {Diabetes mellitus; Vitamin D; Diabetic kidney disease; Sodium-glucose linked co-transporter 2 inhibitors},
   language = {eng},
   issn = {1420-4096},
   journal = {KIDNEY & BLOOD PRESSURE RESEARCH},
   title = {Pathophysiological Implication of Vitamin D in Diabetic Kidney Disease},
   url = {https://www.karger.com/Article/FullText/514286},
   volume = {46},
   year = {2021}
}

TY  - JOUR
ID  - 1787361
AU  - Galuška, David - Pácal, Lukáš - Kaňková, Kateřina
PY  - 2021
TI  - Pathophysiological Implication of Vitamin D in Diabetic Kidney Disease
JF  - KIDNEY & BLOOD PRESSURE RESEARCH
VL  - 46
IS  - 2
SP  - 152-161
EP  - 152-161
PB  - KARGER
SN  - 14204096
KW  - Diabetes mellitus
KW  - Vitamin D
KW  - Diabetic kidney disease
KW  - Sodium-glucose linked co-transporter 2 inhibitors
UR  - https://www.karger.com/Article/FullText/514286
N2  - Background: Vitamin D is a hormone regulating not only calcium and phosphate homeostasis but also, at the same time, exerting many other extraskeletal functions via genomic effects (gene transcription) and probably by non-genomic effects as well. Availability is ensured by dietary intake of its precursors and by de novo production via sunlight. Yet, vitamin D deficiency and insufficiency are very common across the globe and are connected to many pathophysiological states, for example, diabetes mellitus, allergies, autoimmune diseases, pregnancy complications, and recently have also been associated with worse COVID-19 clinical outcomes. Summary: In this review, we summarize current knowledge about vitamin D metabolism in general, its role in diabetes mellitus (mainly type 2) and diabetic complications (mainly diabetic kidney disease), and potential therapeutic perspectives including vitamin D signalling as a druggable target. Key Messages: Vitamin D is not only a vitamin but also a hormone involved in many physiological processes. Its insufficiency or deficiency can lead to many pathological states.
ER  -

GALUŠKA, David, Lukáš PÁCAL and Kateřina KAŇKOVÁ. Pathophysiological Implication of Vitamin D in Diabetic Kidney Disease. \textit{KIDNEY \&{} BLOOD PRESSURE RESEARCH}. BASEL: KARGER, 2021, vol.~46, No~2, p.~152-161. ISSN~1420-4096. Available from: https://dx.doi.org/10.1159/000514286.

Detailed Information on Publication Record