The APOE4 allele is associated with a decreased risk of
retinopathy in type 2 diabetics

J 2021

The APOE4 allele is associated with a decreased risk of retinopathy in type 2 diabetics

DLOUHA, Lucie, Terezie PELIKANOVA, Jiri VELEBA, Vera ADAMKOVA, Vera LANSKA et. al.

Basic information

Original name

The APOE4 allele is associated with a decreased risk of retinopathy in type 2 diabetics

Authors

DLOUHA, Lucie (203 Czech Republic), Terezie PELIKANOVA (203 Czech Republic), Jiri VELEBA (203 Czech Republic), Vera ADAMKOVA (203 Czech Republic), Vera LANSKA (203 Czech Republic), Tomas SOSNA (203 Czech Republic), Lukáš PÁCAL (203 Czech Republic, belonging to the institution), Kateřina KAŇKOVÁ (203 Czech Republic, belonging to the institution) and Jaroslav A. HUBACEK (203 Czech Republic, guarantor)

Edition

MOLECULAR BIOLOGY REPORTS, DORDRECHT, Springer, 2021, 0301-4851

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10608 Biochemistry and molecular biology

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.742

RIV identification code

RIV/00216224:14110/21:00120128

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1007/s11033-021-06581-w

UT WoS

000679622300004

Keywords in English

Retinopathy; T2DM; Apolipoprotein E; Polymorphism; Gender

Abstract

V originále

Background Common polymorphisms within the apolipoprotein E (APOE) gene are suggested to be associated with the development of type 2 diabetes mellitus (T2DM), but the potential association with T2DM complications (nephropathy, neuropathy and retinopathy) remains unclear. We perform the case-control study to analyse the association between the APOE polymorphism and risk of T2DM and to analysed the potential relationship between the APOE and T2DM complications. Methods and results APOE variants (rs429358 and rs7412) were genotyped by TaqMan assay in T2DM patients (N = 1274; N = 829 with complications including retinopathy, neuropathy and nephropathy status) and with PCR-RFLP in healthy nondiabetic controls (N = 2055). The comparison of subjects with genotypes associated with low plasma cholesterol (APOE2/E2 and APOE2/E3 carriers vs. others) did not show an association with T2DM (OR [95% CI] = 0.88 [0.71-1.08). The differences remained insignificant after adjusting for diabetes duration, sex and BMI. Carriers of at least one APOE4 allele (rs429358) are protected against T2DM related retinopathy (OR [95% CI] = 0.65 [0.42-0.99]. Protection against retinopathy is driven mostly by females (OR [95% CI] = 0.50 [0.25-0.99]); and remains significant (P = 0.044) after adjustment for diabetes duration and BMI. Conclusion Common APOE polymorphism was not associated with T2DM in the Czech population. Yet, APOE4 allele revealed an association with retinopathy. In particular, female T2DM patients with at least one APOE4 allele exhibit lower prevalence of retinopathy in our study subjects.

Links

NV18-01-00046, research and development project

Name: Genetické skóre v predikci rizika diabetu a jeho komplikací

Investor: Ministry of Health of the CR

Citovat

DLOUHA, Lucie, Terezie PELIKANOVA, Jiri VELEBA, Vera ADAMKOVA, Vera LANSKA, Tomas SOSNA, Lukáš PÁCAL, Kateřina KAŇKOVÁ and Jaroslav A. HUBACEK. The APOE4 allele is associated with a decreased risk of retinopathy in type 2 diabetics. MOLECULAR BIOLOGY REPORTS. DORDRECHT: Springer, 2021, vol. 48, No 8, p. 5873-5879. ISSN 0301-4851. Available from: https://dx.doi.org/10.1007/s11033-021-06581-w.

@article{1787362,
   author = {Dlouha, Lucie and Pelikanova, Terezie and Veleba, Jiri and Adamkova, Vera and Lanska, Vera and Sosna, Tomas and Pácal, Lukáš and Kaňková, Kateřina and Hubacek, Jaroslav A.},
   article_location = {DORDRECHT},
   article_number = {8},
   doi = {http://dx.doi.org/10.1007/s11033-021-06581-w},
   keywords = {Retinopathy; T2DM; Apolipoprotein E; Polymorphism; Gender},
   language = {eng},
   issn = {0301-4851},
   journal = {MOLECULAR BIOLOGY REPORTS},
   title = {The APOE4 allele is associated with a decreased risk of retinopathy in type 2 diabetics},
   url = {https://link.springer.com/article/10.1007%2Fs11033-021-06581-w},
   volume = {48},
   year = {2021}
}

TY  - JOUR
ID  - 1787362
AU  - Dlouha, Lucie - Pelikanova, Terezie - Veleba, Jiri - Adamkova, Vera - Lanska, Vera - Sosna, Tomas - Pácal, Lukáš - Kaňková, Kateřina - Hubacek, Jaroslav A.
PY  - 2021
TI  - The APOE4 allele is associated with a decreased risk of retinopathy in type 2 diabetics
JF  - MOLECULAR BIOLOGY REPORTS
VL  - 48
IS  - 8
SP  - 5873-5879
EP  - 5873-5879
PB  - Springer
SN  - 03014851
KW  - Retinopathy
KW  - T2DM
KW  - Apolipoprotein E
KW  - Polymorphism
KW  - Gender
UR  - https://link.springer.com/article/10.1007%2Fs11033-021-06581-w
N2  - Background Common polymorphisms within the apolipoprotein E (APOE) gene are suggested to be associated with the development of type 2 diabetes mellitus (T2DM), but the potential association with T2DM complications (nephropathy, neuropathy and retinopathy) remains unclear. We perform the case-control study to analyse the association between the APOE polymorphism and risk of T2DM and to analysed the potential relationship between the APOE and T2DM complications. Methods and results APOE variants (rs429358 and rs7412) were genotyped by TaqMan assay in T2DM patients (N = 1274; N = 829 with complications including retinopathy, neuropathy and nephropathy status) and with PCR-RFLP in healthy nondiabetic controls (N = 2055). The comparison of subjects with genotypes associated with low plasma cholesterol (APOE2/E2 and APOE2/E3 carriers vs. others) did not show an association with T2DM (OR [95% CI] = 0.88 [0.71-1.08). The differences remained insignificant after adjusting for diabetes duration, sex and BMI. Carriers of at least one APOE4 allele (rs429358) are protected against T2DM related retinopathy (OR [95% CI] = 0.65 [0.42-0.99]. Protection against retinopathy is driven mostly by females (OR [95% CI] = 0.50 [0.25-0.99]); and remains significant (P = 0.044) after adjustment for diabetes duration and BMI. Conclusion Common APOE polymorphism was not associated with T2DM in the Czech population. Yet, APOE4 allele revealed an association with retinopathy. In particular, female T2DM patients with at least one APOE4 allele exhibit lower prevalence of retinopathy in our study subjects.
ER  -

DLOUHA, Lucie, Terezie PELIKANOVA, Jiri VELEBA, Vera ADAMKOVA, Vera LANSKA, Tomas SOSNA, Lukáš PÁCAL, Kateřina KAŇKOVÁ and Jaroslav A. HUBACEK. The APOE4 allele is associated with a decreased risk of retinopathy in type 2 diabetics. \textit{MOLECULAR BIOLOGY REPORTS}. DORDRECHT: Springer, 2021, vol.~48, No~8, p.~5873-5879. ISSN~0301-4851. Available from: https://dx.doi.org/10.1007/s11033-021-06581-w.

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