Donor specific anti-HLA antibodies and cardiac allograft
vasculopathy: A prospective study using highly automated 3-D
optical coherence tomography analysis

J 2021

Donor specific anti-HLA antibodies and cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis

PAZDERNIK, Michal, Helena BEDANOVA, Zhi CHEN, Josef KAUTZNER, Vojtech MELENOVSKY et. al.

Basic information

Original name

Donor specific anti-HLA antibodies and cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis

Authors

PAZDERNIK, Michal (203 Czech Republic, guarantor), Helena BEDANOVA (203 Czech Republic), Zhi CHEN, Josef KAUTZNER (203 Czech Republic), Vojtech MELENOVSKY (203 Czech Republic), Ivan MALEK (203 Czech Republic), Antonij SLAVCEV, Michaela BARTONOVA (203 Czech Republic), Vladimir KARMAZIN (203 Czech Republic), Tomas ECKHARDT (203 Czech Republic), Ales TOMASEK (203 Czech Republic), Eva OZÁBALOVÁ (203 Czech Republic, belonging to the institution), Tomas KOVARNIK (203 Czech Republic), Peter WOHLFAHRT (203 Czech Republic) and Milan SONKA (203 Czech Republic)

Edition

Transplant Immunology, Amsterdam, ELSEVIER, 2021, 0966-3274

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30213 Transplantation

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.032

RIV identification code

RIV/00216224:14110/21:00122148

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.trim.2020.101340

UT WoS

000633033800006

Keywords in English

Cardiac allograft vasculopathy; Donor specific antibodies; Heart transplant; Intimal thickness

Abstract

V originále

Introduction: Recent studies suggested potential positive correlations between HLA-specific antibodies and development of cardiac allograft vasculopathy (CAV). Methods: This prospective two-center study investigated early progression of CAV by coronary optical coherence tomography in 1 month and 12 months after heart transplantation (HTx) in 104 patients. Detection and characterization of donor specific (DSA) and MHC class-I polypeptide-related sequence A (MICA) antibodies were performed before, 1, 6 and 12 months after transplantation. Results: During the first post-HTx year, we observed a significant reduction in the mean coronary luminal area (P < .001), and progression in mean intimal thickness (IT) (P < .001). DSA and anti-MICA occurred in 17% of all patients, but no significant relationship was observed between presence of DSA/anti-MICA and IT progression within 12 months after HTx. In contrast, we observed significant association between presence of DSA (p=0.031), de-novo DSA (p=0.031), HLA Class II DSA (p=0.017) and media thickness (MT) progression. Conclusion: Results of our study did not identify a direct association between presence of DSA/anti-MICA and intimal thickness progression in an early period after HTx. However, we found significant relationships between DSA and media thickness progression that may identify a newly recognized immune-pathological aspect of CAV.

Citovat

PAZDERNIK, Michal, Helena BEDANOVA, Zhi CHEN, Josef KAUTZNER, Vojtech MELENOVSKY, Ivan MALEK, Antonij SLAVCEV, Michaela BARTONOVA, Vladimir KARMAZIN, Tomas ECKHARDT, Ales TOMASEK, Eva OZÁBALOVÁ, Tomas KOVARNIK, Peter WOHLFAHRT and Milan SONKA. Donor specific anti-HLA antibodies and cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis. Transplant Immunology. Amsterdam: ELSEVIER, 2021, vol. 65, April 2021, p. 1-8. ISSN 0966-3274. Available from: https://dx.doi.org/10.1016/j.trim.2020.101340.

@article{1787477,
   author = {Pazdernik, Michal and Bedanova, Helena and Chen, Zhi and Kautzner, Josef and Melenovsky, Vojtech and Malek, Ivan and Slavcev, Antonij and Bartonova, Michaela and Karmazin, Vladimir and Eckhardt, Tomas and Tomasek, Ales and Ozábalová, Eva and Kovarnik, Tomas and Wohlfahrt, Peter and Sonka, Milan},
   article_location = {Amsterdam},
   article_number = {April 2021},
   doi = {http://dx.doi.org/10.1016/j.trim.2020.101340},
   keywords = {Cardiac allograft vasculopathy; Donor specific antibodies; Heart transplant; Intimal thickness},
   language = {eng},
   issn = {0966-3274},
   journal = {Transplant Immunology},
   title = {Donor specific anti-HLA antibodies and cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis},
   url = {https://www.sciencedirect.com/science/article/pii/S0966327420301489?via%3Dihub},
   volume = {65},
   year = {2021}
}

TY  - JOUR
ID  - 1787477
AU  - Pazdernik, Michal - Bedanova, Helena - Chen, Zhi - Kautzner, Josef - Melenovsky, Vojtech - Malek, Ivan - Slavcev, Antonij - Bartonova, Michaela - Karmazin, Vladimir - Eckhardt, Tomas - Tomasek, Ales - Ozábalová, Eva - Kovarnik, Tomas - Wohlfahrt, Peter - Sonka, Milan
PY  - 2021
TI  - Donor specific anti-HLA antibodies and cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis
JF  - Transplant Immunology
VL  - 65
IS  - April 2021
SP  - 1-8
EP  - 1-8
PB  - ELSEVIER
SN  - 09663274
KW  - Cardiac allograft vasculopathy
KW  - Donor specific antibodies
KW  - Heart transplant
KW  - Intimal thickness
UR  - https://www.sciencedirect.com/science/article/pii/S0966327420301489?via%3Dihub
N2  - Introduction: Recent studies suggested potential positive correlations between HLA-specific antibodies and development of cardiac allograft vasculopathy (CAV). Methods: This prospective two-center study investigated early progression of CAV by coronary optical coherence tomography in 1 month and 12 months after heart transplantation (HTx) in 104 patients. Detection and characterization of donor specific (DSA) and MHC class-I polypeptide-related sequence A (MICA) antibodies were performed before, 1, 6 and 12 months after transplantation. Results: During the first post-HTx year, we observed a significant reduction in the mean coronary luminal area (P < .001), and progression in mean intimal thickness (IT) (P < .001). DSA and anti-MICA occurred in 17% of all patients, but no significant relationship was observed between presence of DSA/anti-MICA and IT progression within 12 months after HTx. In contrast, we observed significant association between presence of DSA (p=0.031), de-novo DSA (p=0.031), HLA Class II DSA (p=0.017) and media thickness (MT) progression. Conclusion: Results of our study did not identify a direct association between presence of DSA/anti-MICA and intimal thickness progression in an early period after HTx. However, we found significant relationships between DSA and media thickness progression that may identify a newly recognized immune-pathological aspect of CAV.
ER  -

PAZDERNIK, Michal, Helena BEDANOVA, Zhi CHEN, Josef KAUTZNER, Vojtech MELENOVSKY, Ivan MALEK, Antonij SLAVCEV, Michaela BARTONOVA, Vladimir KARMAZIN, Tomas ECKHARDT, Ales TOMASEK, Eva OZÁBALOVÁ, Tomas KOVARNIK, Peter WOHLFAHRT and Milan SONKA. Donor specific anti-HLA antibodies and cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis. \textit{Transplant Immunology}. Amsterdam: ELSEVIER, 2021, vol.~65, April 2021, p.~1-8. ISSN~0966-3274. Available from: https://dx.doi.org/10.1016/j.trim.2020.101340.

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