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@article{1787477,
author = {Pazdernik, Michal and Bedanova, Helena and Chen, Zhi and Kautzner, Josef and Melenovsky, Vojtech and Malek, Ivan and Slavcev, Antonij and Bartonova, Michaela and Karmazin, Vladimir and Eckhardt, Tomas and Tomasek, Ales and Ozábalová, Eva and Kovarnik, Tomas and Wohlfahrt, Peter and Sonka, Milan},
article_location = {Amsterdam},
article_number = {April 2021},
doi = {http://dx.doi.org/10.1016/j.trim.2020.101340},
keywords = {Cardiac allograft vasculopathy; Donor specific antibodies; Heart transplant; Intimal thickness},
language = {eng},
issn = {0966-3274},
journal = {Transplant Immunology},
title = {Donor specific anti-HLA antibodies and cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis},
url = {https://www.sciencedirect.com/science/article/pii/S0966327420301489?via%3Dihub},
volume = {65},
year = {2021}
}
TY - JOUR
ID - 1787477
AU - Pazdernik, Michal - Bedanova, Helena - Chen, Zhi - Kautzner, Josef - Melenovsky, Vojtech - Malek, Ivan - Slavcev, Antonij - Bartonova, Michaela - Karmazin, Vladimir - Eckhardt, Tomas - Tomasek, Ales - Ozábalová, Eva - Kovarnik, Tomas - Wohlfahrt, Peter - Sonka, Milan
PY - 2021
TI - Donor specific anti-HLA antibodies and cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis
JF - Transplant Immunology
VL - 65
IS - April 2021
SP - 1-8
EP - 1-8
PB - ELSEVIER
SN - 09663274
KW - Cardiac allograft vasculopathy
KW - Donor specific antibodies
KW - Heart transplant
KW - Intimal thickness
UR - https://www.sciencedirect.com/science/article/pii/S0966327420301489?via%3Dihub
N2 - Introduction: Recent studies suggested potential positive correlations between HLA-specific antibodies and development of cardiac allograft vasculopathy (CAV). Methods: This prospective two-center study investigated early progression of CAV by coronary optical coherence tomography in 1 month and 12 months after heart transplantation (HTx) in 104 patients. Detection and characterization of donor specific (DSA) and MHC class-I polypeptide-related sequence A (MICA) antibodies were performed before, 1, 6 and 12 months after transplantation. Results: During the first post-HTx year, we observed a significant reduction in the mean coronary luminal area (P < .001), and progression in mean intimal thickness (IT) (P < .001). DSA and anti-MICA occurred in 17% of all patients, but no significant relationship was observed between presence of DSA/anti-MICA and IT progression within 12 months after HTx. In contrast, we observed significant association between presence of DSA (p=0.031), de-novo DSA (p=0.031), HLA Class II DSA (p=0.017) and media thickness (MT) progression. Conclusion: Results of our study did not identify a direct association between presence of DSA/anti-MICA and intimal thickness progression in an early period after HTx. However, we found significant relationships between DSA and media thickness progression that may identify a newly recognized immune-pathological aspect of CAV.
ER -
PAZDERNIK, Michal, Helena BEDANOVA, Zhi CHEN, Josef KAUTZNER, Vojtech MELENOVSKY, Ivan MALEK, Antonij SLAVCEV, Michaela BARTONOVA, Vladimir KARMAZIN, Tomas ECKHARDT, Ales TOMASEK, Eva OZÁBALOVÁ, Tomas KOVARNIK, Peter WOHLFAHRT and Milan SONKA. Donor specific anti-HLA antibodies and cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis. \textit{Transplant Immunology}. Amsterdam: ELSEVIER, 2021, vol.~65, April 2021, p.~1-8. ISSN~0966-3274. Available from: https://dx.doi.org/10.1016/j.trim.2020.101340.
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