POKRIVČÁK, Tomáš, Radek LAKOMÝ, Tomáš KAZDA, Alexandr POPRACH, Pavel FABIAN and Igor KISS. The use of cisplatin in patients after kidney transplantation with chronic renal insufficiency Is the benefit higher than potential risks in therapy of non-seminomatous germ cell tumors? Medicine. Philadelphia: Lippincott Williams & Wilkins, 2021, vol. 100, No 24, p. 1-3. ISSN 0025-7974. Available from: https://dx.doi.org/10.1097/MD.0000000000026381.
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Basic information
Original name The use of cisplatin in patients after kidney transplantation with chronic renal insufficiency Is the benefit higher than potential risks in therapy of non-seminomatous germ cell tumors?
Authors POKRIVČÁK, Tomáš (203 Czech Republic, belonging to the institution), Radek LAKOMÝ (203 Czech Republic, belonging to the institution), Tomáš KAZDA (203 Czech Republic), Alexandr POPRACH (203 Czech Republic), Pavel FABIAN (203 Czech Republic, belonging to the institution) and Igor KISS (203 Czech Republic, guarantor, belonging to the institution).
Edition Medicine, Philadelphia, Lippincott Williams & Wilkins, 2021, 0025-7974.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30218 General and internal medicine
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 1.817
RIV identification code RIV/00216224:14110/21:00122153
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1097/MD.0000000000026381
UT WoS 000661624000058
Keywords in English cisplatin; germ-cell tumor; nephrotoxicity; treatment
Tags 14110811, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 24/8/2021 10:23.
Abstract
Rationale: The use of cisplatin in patients with chronic kidney disease (CKD) is risky and depends on a number of factors. The optimal procedure in stage I of a non seminomatous germ cell tumor without proven lymphangioinvasion after orchiectomy is controversial and is the subject of a number of discussions due to the lack of randomized studies assessing individual treatment options. The adjuvant method of choice is surveillance or application of cisplatin-based chemotherapy with the risk of treatment related nephrotoxicity. Information about cisplatin safety in renal transplant patients is particularly limited. The aim of this paper is to share the experience with the application of adjuvant chemotherapy Bleomycin, Etoposide, Cisplatin (BEP) in high-risk patient with nonseminoma after kidney transplantation. Patient concerns: We report a case report of rare group of high-risk patient with non-seminomatous germ cell testicular tumor (NSGCT) after kidney transplantation before application of adjuvant chemotherapy BEP. Patient presented with month-long discomfort in the scrotal area. Previously, he was treated with chronic kidney disease based on chronic glomerulonephritis, which was treated with repeated kidney transplantation. Diagnosis: The ultrasound examination for a month-long discomfort in the scrotal area found a solid mass of the left testis. Radical inguinal orchiectomy confirmed NSGCT with the presence of lymphovascular invasion (LVI). Postoperative staging with computed tomography of the chest and abdomen did not show obvious dissemination of the disease. Interventions: Reducing original dose of chemotherapeutics according to the recommendations of the summary of product characteristics led to only a transient increase in creatinine levels. Outcomes: The 5-year risk of relapse in surveillance was reduced to around 3% by applying cisplatin-based chemotherapy. Lessons: Application of cisplatin-based chemotherapy is safe and effective in patients with CKD and in patients with a kidney transplant.
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