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@article{1787519,
author = {Krtička, Milan and Nekuda, Vladimír and Ira, Daniel and Sedlacek, Radek and Suchy, Tomas and Kavkova, Michaela and Brinek, Adam and Gopfrt, Eduard and Bilik, Andrej and Kaiser, Jozef and Křen, Leoš and Plánka, Ladislav},
article_location = {Brno},
article_number = {1},
doi = {http://dx.doi.org/10.2754/avb202190010069},
keywords = {Bone replacement; spine; injury},
language = {eng},
issn = {0001-7213},
journal = {Acta veterinaria (Brno)},
title = {Microcomputed tomographic, biomechanical and histological analyses of lumbar interbody fusion with iliac crest bone graft in a pig model},
url = {https://actavet.vfu.cz/90/1/0069/},
volume = {90},
year = {2021}
}
TY - JOUR
ID - 1787519
AU - Krtička, Milan - Nekuda, Vladimír - Ira, Daniel - Sedlacek, Radek - Suchy, Tomas - Kavkova, Michaela - Brinek, Adam - Gopfrt, Eduard - Bilik, Andrej - Kaiser, Jozef - Křen, Leoš - Plánka, Ladislav
PY - 2021
TI - Microcomputed tomographic, biomechanical and histological analyses of lumbar interbody fusion with iliac crest bone graft in a pig model
JF - Acta veterinaria (Brno)
VL - 90
IS - 1
SP - 69-75
EP - 69-75
PB - VETERINARNI A FARMACEUTICKA UNIVERZITA BRNO
SN - 00017213
KW - Bone replacement
KW - spine
KW - injury
UR - https://actavet.vfu.cz/90/1/0069/
N2 - The main goal of this study was to assess the progress of vertebral stability after lumbar interbody fusion related to microcomputed tomography (micro CT), biomechanical analysis, and histological assessment towards spine fusion. Twelve male pigs were used; each underwent L2-3 discectomy and implantation of an iliac crest bone graft in two groups; six spines were harvested eight weeks (A1) and six spines 16 weeks (A2) after surgery (7 native spines for biomechanical analysis). The CT was performed by GE phoenix datos vertical bar x 2.0 with a sample drift correction. The samples were divided according to fusion quality. Biomechanical evaluation was carried out on the MTS Mini Bionix testing system. In the nondestructive mode, three cycles of pure bending moments were applied (5 Nm load limit) at a rate of 20 degrees/min in flexion (+40 degrees) and extension (-40 degrees). Two representative histological sections from four samples were obtained (A1, n = 2; A2, n = 2); areas of mature bone were quantified. In micro CT, better results were achieved in group A2 (not significant). Eight weeks after the operation, flexural stiffness decreased to 48% of its initial value for native cadavers (P < 0.05); after 16 weeks it was comparable to native cadavers, demonstrating the suitability of the implanted graft (P < 0.05). The newly formed bone tissue occupied an average area of 94.205 mm(2) (A1) and 26.240 mm(2) (A2). It was confirmed that micro CT, biomechanical analysis, and histological assessment are technically feasible and suitable for the evaluation of results of other methods of large bone defect treatment.
ER -
KRTIČKA, Milan, Vladimír NEKUDA, Daniel IRA, Radek SEDLACEK, Tomas SUCHY, Michaela KAVKOVA, Adam BRINEK, Eduard GOPFRT, Andrej BILIK, Jozef KAISER, Leoš KŘEN and Ladislav PLÁNKA. Microcomputed tomographic, biomechanical and histological analyses of lumbar interbody fusion with iliac crest bone graft in a pig model. \textit{Acta veterinaria (Brno)}. Brno: VETERINARNI A FARMACEUTICKA UNIVERZITA BRNO, 2021, vol.~90, No~1, p.~69-75. ISSN~0001-7213. Available from: https://dx.doi.org/10.2754/avb202190010069.
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