| BLAZEK, T, Z CERMAKOVA, L KNYBEL, Pavel HURNÍK, Jan ŠTEMBÍREK, K RESOVA, T PARACKOVA, Martin FORMÁNEK, Jakub CVEK and Renata SOUMAROVÁ. Dose escalation in advanced floor of the mouth cancer: a pilot study using a combination of IMRT and stereotactic boost. International Journal of Radiation Oncology Biology Physics. New York: Elsevier Inc., 2021, vol. 16, No 1, 9 pp. ISSN 0360-3016. Available from: https://dx.doi.org/10.1186/s13014-021-01842-1. |
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@article{1787940,
author = {Blazek, T and Cermakova, Z and Knybel, L and Hurník, Pavel and Štembírek, Jan and Resova, K and Parackova, T and Formánek, Martin and Cvek, Jakub and Soumarová, Renata},
article_location = {New York},
article_number = {1},
doi = {http://dx.doi.org/10.1186/s13014-021-01842-1},
keywords = {Oral cavity tumor; Floor of the mouth tumor; CyberKnife; CyberKnife boost; Stereotactic radiotherapy; Hypofractionated boost},
language = {eng},
issn = {0360-3016},
journal = {International Journal of Radiation Oncology Biology Physics},
title = {Dose escalation in advanced floor of the mouth cancer: a pilot study using a combination of IMRT and stereotactic boost},
volume = {16},
year = {2021}
}
TY - JOUR
ID - 1787940
AU - Blazek, T - Cermakova, Z - Knybel, L - Hurník, Pavel - Štembírek, Jan - Resova, K - Parackova, T - Formánek, Martin - Cvek, Jakub - Soumarová, Renata
PY - 2021
TI - Dose escalation in advanced floor of the mouth cancer: a pilot study using a combination of IMRT and stereotactic boost
JF - International Journal of Radiation Oncology Biology Physics
VL - 16
IS - 1
PB - Elsevier Inc.
SN - 03603016
KW - Oral cavity tumor
KW - Floor of the mouth tumor
KW - CyberKnife
KW - CyberKnife boost
KW - Stereotactic radiotherapy
KW - Hypofractionated boost
N2 - Purpose We evaluated the efficiency and toxicity of stereotactic hypofractionated boost in combination with conventionally fractionated radiotherapy in the treatment of advanced floor of the mouth cancer. Methods Thirty-seven patients with advanced stage of the floor of the mouth cancer, histologically confirmed squamous cell carcinoma (p16 negative) ineligible for surgical treatment, were indicated for radiochemotherapy or hyperfractionated accelerated radiotherapy (HART). The radiotherapy protocol combined external beam radiotherapy (EBRT) and a stereotactic hypofractionated boost to the primary tumor. The dose delivered from EBRT was 70-72.5 Gy in 35/50 fractions. The hypofractionated boost followed with 10 Gy in two fractions. For the variables-tumor volume, stage and grade a multivariate analysis was performed to find the relationship between overall survival, local progression and metastasis. Toxicity was evaluated according to CTCAE scale version 4. Results After a median follow-up of 16 months, 23 patients (62%) achieved complete remission. The median time to local progression and metastasis was 7 months. Local control (LC) at 2 and 5-years was 70% and 62%, respectively. Progression-free survival (PFS) and overall survival (OS) were 57% and 49% at 2 years and 41% and 27% at 5 years, respectively. Statistical analysis revealed that larger tumors had worse overall survival and a greater chance of metastasis. Log-Rank GTV > 44 ccm (HR = 1.96; [95% CI (0.87; 4.38)]; p = 0.11). No boost-related severe acute toxicity was observed. Late osteonecrosis was observed in 3 patients (8%). Conclusion The combination of EBRT and stereotactic hypofractionated boost is safe and seems to be an effective option for dose escalation in patients with advanced floor of the mouth tumors who are ineligible for surgical treatment and require a non-invasive approach.
ER -
BLAZEK, T, Z CERMAKOVA, L KNYBEL, Pavel HURNÍK, Jan ŠTEMBÍREK, K RESOVA, T PARACKOVA, Martin FORMÁNEK, Jakub CVEK and Renata SOUMAROVÁ. Dose escalation in advanced floor of the mouth cancer: a pilot study using a combination of IMRT and stereotactic boost. \textit{International Journal of Radiation Oncology Biology Physics}. New York: Elsevier Inc., 2021, vol.~16, No~1, 9 pp. ISSN~0360-3016. Available from: https://dx.doi.org/10.1186/s13014-021-01842-1.
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