Influence of heart rate correction formulas on QTc interval
stability

J 2021

Influence of heart rate correction formulas on QTc interval stability

ANDRŠOVÁ, Irena, Katerina HNATKOVA, Martina ŠIŠÁKOVÁ, Ondřej TOMAN, Peter SMETANA et. al.

Basic information

Original name

Influence of heart rate correction formulas on QTc interval stability

Authors

ANDRŠOVÁ, Irena (203 Czech Republic, belonging to the institution), Katerina HNATKOVA (203 Czech Republic), Martina ŠIŠÁKOVÁ (203 Czech Republic, belonging to the institution), Ondřej TOMAN (203 Czech Republic, belonging to the institution), Peter SMETANA, Katharina M. HUSTER, Petra BARTHEL, Tomáš NOVOTNÝ (203 Czech Republic, belonging to the institution), Georg SCHMIDT and Marek MALÍK (203 Czech Republic, guarantor, belonging to the institution)

Edition

Scientific Reports, London, NATURE RESEARCH, 2021, 2045-2322

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10700 1.7 Other natural sciences

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.996

RIV identification code

RIV/00216224:14110/21:00122181

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1038/s41598-021-93774-9

UT WoS

000677492300011

Keywords in English

heart rate correction formulas; QTc interval stability

Abstract

V originále

Monitoring of QTc interval is mandated in different clinical conditions. Nevertheless, intra-subject variability of QTc intervals reduces the clinical utility of QTc monitoring strategies. Since this variability is partly related to QT heart rate correction, 10 different heart rate corrections (Bazett, Fridericia, Dmitrienko, Framingham, Schlamowitz, Hodges, Ashman, Rautaharju, Sarma, and Rabkin) were applied to 452,440 ECG measurements made in 539 healthy volunteers (259 females, mean age 33.3 +/- 8.4 years). For each correction formula, the short term (5-min time-points) and long-term (day-time hours) variability of rate corrected QT values (QTc) was investigated together with the comparisons of the QTc values with individually corrected QTcI values obtained by subject-specific modelling of the QT/RR relationship and hysteresis. The results showed that (a) both in terms of short-term and long-term QTc variability, Bazett correction led to QTc values that were more variable than the results of other corrections (p<0.00001 for all), (b) the QTc variability by Fridericia and Framingham corrections were not systematically different from each other but were lower than the results of other corrections (p-value between 0.033 and<0.00001), and (c) on average, Bazett QTc values departed from QTcI intervals more than the QTc values of other corrections. The study concludes that (a) previous suggestions that Bazett correction should no longer be used in clinical practice are fully justified, (b) replacing Bazett correction with Fridericia and/or Framingham corrections would improve clinical QTc monitoring, (c) heart rate stability is needed for valid QTc assessment, and (d) development of further QTc corrections for day-to-day use is not warranted.

Links

MUNI/A/1437/2020, interní kód MU

Name: Nevyřešené otázky a nové metody hodnocení elektrokardiografického signálu a struktur myokardu (Acronym: ECG2021)

Investor: Masaryk University

MUNI/A/1446/2019, interní kód MU

Name: Nevyřešené otázky a nové metody hodnocení elektrokardiografického signálu (Acronym: ECG2020)

Investor: Masaryk University, Category A

Citovat

ANDRŠOVÁ, Irena, Katerina HNATKOVA, Martina ŠIŠÁKOVÁ, Ondřej TOMAN, Peter SMETANA, Katharina M. HUSTER, Petra BARTHEL, Tomáš NOVOTNÝ, Georg SCHMIDT and Marek MALÍK. Influence of heart rate correction formulas on QTc interval stability. Scientific Reports. London: NATURE RESEARCH, 2021, vol. 11, No 1, p. 1-21. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/s41598-021-93774-9.

@article{1788051,
   author = {Andršová, Irena and Hnatkova, Katerina and Šišáková, Martina and Toman, Ondřej and Smetana, Peter and Huster, Katharina M. and Barthel, Petra and Novotný, Tomáš and Schmidt, Georg and Malík, Marek},
   article_location = {London},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s41598-021-93774-9},
   keywords = {heart rate correction formulas; QTc interval stability},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific Reports},
   title = {Influence of heart rate correction formulas on QTc interval stability},
   url = {https://www.nature.com/articles/s41598-021-93774-9},
   volume = {11},
   year = {2021}
}

TY  - JOUR
ID  - 1788051
AU  - Andršová, Irena - Hnatkova, Katerina - Šišáková, Martina - Toman, Ondřej - Smetana, Peter - Huster, Katharina M. - Barthel, Petra - Novotný, Tomáš - Schmidt, Georg - Malík, Marek
PY  - 2021
TI  - Influence of heart rate correction formulas on QTc interval stability
JF  - Scientific Reports
VL  - 11
IS  - 1
SP  - 1-21
EP  - 1-21
PB  - NATURE RESEARCH
SN  - 20452322
KW  - heart rate correction formulas
KW  - QTc interval stability
UR  - https://www.nature.com/articles/s41598-021-93774-9
N2  - Monitoring of QTc interval is mandated in different clinical conditions. Nevertheless, intra-subject variability of QTc intervals reduces the clinical utility of QTc monitoring strategies. Since this variability is partly related to QT heart rate correction, 10 different heart rate corrections (Bazett, Fridericia, Dmitrienko, Framingham, Schlamowitz, Hodges, Ashman, Rautaharju, Sarma, and Rabkin) were applied to 452,440 ECG measurements made in 539 healthy volunteers (259 females, mean age 33.3 +/- 8.4 years). For each correction formula, the short term (5-min time-points) and long-term (day-time hours) variability of rate corrected QT values (QTc) was investigated together with the comparisons of the QTc values with individually corrected QTcI values obtained by subject-specific modelling of the QT/RR relationship and hysteresis. The results showed that (a) both in terms of short-term and long-term QTc variability, Bazett correction led to QTc values that were more variable than the results of other corrections (p<0.00001 for all), (b) the QTc variability by Fridericia and Framingham corrections were not systematically different from each other but were lower than the results of other corrections (p-value between 0.033 and<0.00001), and (c) on average, Bazett QTc values departed from QTcI intervals more than the QTc values of other corrections. The study concludes that (a) previous suggestions that Bazett correction should no longer be used in clinical practice are fully justified, (b) replacing Bazett correction with Fridericia and/or Framingham corrections would improve clinical QTc monitoring, (c) heart rate stability is needed for valid QTc assessment, and (d) development of further QTc corrections for day-to-day use is not warranted.
ER  -

ANDRŠOVÁ, Irena, Katerina HNATKOVA, Martina ŠIŠÁKOVÁ, Ondřej TOMAN, Peter SMETANA, Katharina M. HUSTER, Petra BARTHEL, Tomáš NOVOTNÝ, Georg SCHMIDT and Marek MALÍK. Influence of heart rate correction formulas on QTc interval stability. \textit{Scientific Reports}. London: NATURE RESEARCH, 2021, vol.~11, No~1, p.~1-21. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-021-93774-9.

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