ZELANTE, Teresa, Tsokyi CHOERA, Anne BEAUVAIS, Francesca FALLARINO, Giuseppe PAOLICELLI, Giuseppe PIERACCINI, Marco PIERONI, Claudia GALOSI, Claudia BEATO, Antonella DE LUCA, Francesca BOSCARO, Riccardo ROMOLI, Xin LIU, Adilia WARRIS, Paul E. VERWEIJ, Eloise BALLARD, Monica BORGHI, Marilena PARIANO, Gabriele COSTANTINO, Mario CALVITTI, Carmine VACCA, Vasilis OIKONOMOU, Marco GARGARO, Alicia Yoke Wei WONG, Louis BOON, Marcel DEN HARTOG, Zdeněk SPÁČIL, Paolo PUCCETTI, Jean-Paul LATGE, Nancy P. KELLER a Luigina ROMANI. Aspergillus fumigatus tryptophan metabolic route differently affects host immunity. Cell Reports. CAMBRIDGE: Cell Press, 2021, roč. 34, č. 4, s. 1-20. ISSN 2211-1247. Dostupné z: https://dx.doi.org/10.1016/j.celrep.2020.108673. |
Další formáty:
BibTeX
LaTeX
RIS
@article{1788181, author = {Zelante, Teresa and Choera, Tsokyi and Beauvais, Anne and Fallarino, Francesca and Paolicelli, Giuseppe and Pieraccini, Giuseppe and Pieroni, Marco and Galosi, Claudia and Beato, Claudia and De Luca, Antonella and Boscaro, Francesca and Romoli, Riccardo and Liu, Xin and Warris, Adilia and Verweij, Paul E. and Ballard, Eloise and Borghi, Monica and Pariano, Marilena and Costantino, Gabriele and Calvitti, Mario and Vacca, Carmine and Oikonomou, Vasilis and Gargaro, Marco and Wong, Alicia Yoke Wei and Boon, Louis and den Hartog, Marcel and Spáčil, Zdeněk and Puccetti, Paolo and Latge, JeanandPaul and Keller, Nancy P. and Romani, Luigina}, article_location = {CAMBRIDGE}, article_number = {4}, doi = {http://dx.doi.org/10.1016/j.celrep.2020.108673}, keywords = {aspergillosis; indoles; Aspergillus fumigatus; IDO; tryptophan; AhR; IL-33; NAD; inflammation}, language = {eng}, issn = {2211-1247}, journal = {Cell Reports}, title = {Aspergillus fumigatus tryptophan metabolic route differently affects host immunity}, url = {https://www.sciencedirect.com/science/article/pii/S2211124720316624?via%3Dihub}, volume = {34}, year = {2021} }
TY - JOUR ID - 1788181 AU - Zelante, Teresa - Choera, Tsokyi - Beauvais, Anne - Fallarino, Francesca - Paolicelli, Giuseppe - Pieraccini, Giuseppe - Pieroni, Marco - Galosi, Claudia - Beato, Claudia - De Luca, Antonella - Boscaro, Francesca - Romoli, Riccardo - Liu, Xin - Warris, Adilia - Verweij, Paul E. - Ballard, Eloise - Borghi, Monica - Pariano, Marilena - Costantino, Gabriele - Calvitti, Mario - Vacca, Carmine - Oikonomou, Vasilis - Gargaro, Marco - Wong, Alicia Yoke Wei - Boon, Louis - den Hartog, Marcel - Spáčil, Zdeněk - Puccetti, Paolo - Latge, Jean-Paul - Keller, Nancy P. - Romani, Luigina PY - 2021 TI - Aspergillus fumigatus tryptophan metabolic route differently affects host immunity JF - Cell Reports VL - 34 IS - 4 SP - 1-20 EP - 1-20 PB - Cell Press SN - 22111247 KW - aspergillosis KW - indoles KW - Aspergillus fumigatus KW - IDO KW - tryptophan KW - AhR KW - IL-33 KW - NAD KW - inflammation UR - https://www.sciencedirect.com/science/article/pii/S2211124720316624?via%3Dihub N2 - Indoleamine 2,3-dioxygenases (Ms) degrade L-tryptophan to kynurenines and drive the de novo synthesis of nicotinamide adenine dinucleotide. Unsurprisingly, various invertebrates, vertebrates, and even fungi produce IDO. In mammals, IDO1 also serves as a homeostatic regulator, modulating immune response to infection via local tryptophan deprivation, active catabolite production, and non-enzymatic cell signaling, Whether fungal !dos have pleiotropic functions that impact on host-fungal physiology is unclear. Here, we show that Aspergillus fumigatus possesses three ido genes that are expressed under conditions of hypoxia or tryptophan abundance. Loss of these genes results in increased fungal pathogenicity and inflammation in a mouse model of aspergillosis, driven by an alternative tryptophan degradation pathway to indole derivatives and the host aryl hydrocarbon receptor. Fungal tryptophan metabolic pathways thus cooperate with the host xenobiotic response to shape host-microbe interactions in local tissue microenvironments. ER -
ZELANTE, Teresa, Tsokyi CHOERA, Anne BEAUVAIS, Francesca FALLARINO, Giuseppe PAOLICELLI, Giuseppe PIERACCINI, Marco PIERONI, Claudia GALOSI, Claudia BEATO, Antonella DE LUCA, Francesca BOSCARO, Riccardo ROMOLI, Xin LIU, Adilia WARRIS, Paul E. VERWEIJ, Eloise BALLARD, Monica BORGHI, Marilena PARIANO, Gabriele COSTANTINO, Mario CALVITTI, Carmine VACCA, Vasilis OIKONOMOU, Marco GARGARO, Alicia Yoke Wei WONG, Louis BOON, Marcel DEN HARTOG, Zdeněk SPÁČIL, Paolo PUCCETTI, Jean-Paul LATGE, Nancy P. KELLER a Luigina ROMANI. Aspergillus fumigatus tryptophan metabolic route differently affects host immunity. \textit{Cell Reports}. CAMBRIDGE: Cell Press, 2021, roč.~34, č.~4, s.~1-20. ISSN~2211-1247. Dostupné z: https://dx.doi.org/10.1016/j.celrep.2020.108673.
|