| GONG, Yufeng, Keke ZHANG, Ningbo GENG, Minghuo WU, Xianliang YI, Renyan RY, Jonathan K. CHALLIS, Garry Paul CODLING, Elvis Genbo XU and John Paul GIESY. Molecular mechanisms of zooplanktonic toxicity in the okadaic acid- producing dinoflagellate Prorocentrum lima. Environmental Pollution. OXFORD, OXON, ENGLAND: ELSEVIER SCI LTD, 2021, vol. 279, June 2021, p. 1-10. ISSN 0269-7491. Available from: https://dx.doi.org/10.1016/j.envpol.2021.116942. |
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@article{1789403,
author = {Gong, Yufeng and Zhang, Keke and Geng, Ningbo and Wu, Minghuo and Yi, Xianliang and RY, Renyan and Challis, Jonathan K. and Codling, Garry Paul and Xu, Elvis Genbo and Giesy, John Paul},
article_location = {OXFORD, OXON, ENGLAND},
article_number = {June 2021},
doi = {http://dx.doi.org/10.1016/j.envpol.2021.116942},
keywords = {Transcriptomic; Metabolomics; Toxic algal bloom; Zooplankton},
language = {eng},
issn = {0269-7491},
journal = {Environmental Pollution},
title = {Molecular mechanisms of zooplanktonic toxicity in the okadaic acid- producing dinoflagellate Prorocentrum lima},
url = {https://www.sciencedirect.com/science/article/pii/S0269749121005248?via%3Dihub},
volume = {279},
year = {2021}
}
TY - JOUR
ID - 1789403
AU - Gong, Yufeng - Zhang, Keke - Geng, Ningbo - Wu, Minghuo - Yi, Xianliang - RY, Renyan - Challis, Jonathan K. - Codling, Garry Paul - Xu, Elvis Genbo - Giesy, John Paul
PY - 2021
TI - Molecular mechanisms of zooplanktonic toxicity in the okadaic acid- producing dinoflagellate Prorocentrum lima
JF - Environmental Pollution
VL - 279
IS - June 2021
SP - 1-10
EP - 1-10
PB - ELSEVIER SCI LTD
SN - 02697491
KW - Transcriptomic
KW - Metabolomics
KW - Toxic algal bloom
KW - Zooplankton
UR - https://www.sciencedirect.com/science/article/pii/S0269749121005248?via%3Dihub
N2 - Prorocentrum lima is a dinoflagellate that forms hazardous blooms and produces okadaic acid (OA), leading to adverse environmental consequences associated with the declines of zooplankton pop-ulations. However, little is known about the toxic effects and molecular mechanisms of P. lima or OA on zooplankton. Here, their toxic effects were investigated using the brine shrimp Artemia salina. Acute exposure of A. salina to P. lima resulted in lethality at concentrations 10 0-fold lower than densities observed during blooms. The first comprehensive results from global transcriptomic and metabolomic analyses in A. salina showed up-regulated mRNA expression of antioxidant enzymes and reduced non-enzyme antioxidants, indicating general detoxification responses to oxidative stress after exposure to P. lima. The significantly up-regulated mRNA expression of proteasome, spliceosome, and ribosome, as well as the increased fatty acid oxidation and oxidative phosphorylation suggested the proteolysis of damaged proteins and induction of energy expenditure. Exposure to OA increased catabolism of chitin, which may further disrupt the molting and reproduction activities of A. salina. Our data shed new in-sights on the molecular responses and toxicity mechanisms of A. salina to P. lima or OA. The simple zooplankton model integrated with omic methods provides a sensitive assessment approach for studying hazardous algae.
ER -
GONG, Yufeng, Keke ZHANG, Ningbo GENG, Minghuo WU, Xianliang YI, Renyan RY, Jonathan K. CHALLIS, Garry Paul CODLING, Elvis Genbo XU and John Paul GIESY. Molecular mechanisms of zooplanktonic toxicity in the okadaic acid- producing dinoflagellate Prorocentrum lima. \textit{Environmental Pollution}. OXFORD, OXON, ENGLAND: ELSEVIER SCI LTD, 2021, vol.~279, June 2021, p.~1-10. ISSN~0269-7491. Available from: https://dx.doi.org/10.1016/j.envpol.2021.116942.
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