Medical-Grade Honey as an Alternative Treatment for Antibiotics
in Non-Healing Wounds-A Prospective Case Series

J 2021

Medical-Grade Honey as an Alternative Treatment for Antibiotics in Non-Healing Wounds-A Prospective Case Series

HOLUBOVA, Adela, Lucie CHLUPACOVA, Lada CETLOVA, Niels A. J. CREMERS, Andrea POKORNÁ et. al.

Basic information

Original name

Medical-Grade Honey as an Alternative Treatment for Antibiotics in Non-Healing Wounds-A Prospective Case Series

Authors

HOLUBOVA, Adela (203 Czech Republic, guarantor), Lucie CHLUPACOVA (203 Czech Republic), Lada CETLOVA (203 Czech Republic), Niels A. J. CREMERS (528 Netherlands) and Andrea POKORNÁ (203 Czech Republic, belonging to the institution)

Edition

Antibiotics-Basel, BASEL, MDPI, 2021, 2079-6382

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.222

RIV identification code

RIV/00216224:14110/21:00122262

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3390/antibiotics10080918

UT WoS

000688588000001

Keywords in English

medical grade honey; antibiotic replacement; infections; wounds; objective wound assessment

Abstract

V originále

Non-healing wounds are usually colonised by various types of bacteria. An alternative to antibiotic treatment in patients with infected wounds with local signs of inflammation may be medical-grade honey (MGH), which favourably affects the healing process with its antimicrobial, antioxidant, anti-inflammatory, and immunomodulatory properties. The objective of this study was to evaluate the effect of MGH therapy on the healing process of non-healing wounds of various aetiologies and different wound colonisations. Prospective, observation-intervention case studies (n = 9) of patients with wounds of various aetiologies (venous leg ulcers, diabetic foot ulcers, surgical wound dehiscence) are presented. All wounds were treated with MGH and the healing trajectory was rigorously and objectively monitored. In all cases, pain, odour, and exudation were quickly resolved, which led to an improvement in the quality of life of patients. Despite the proven bacterial microflora in wounds, antibiotic treatment was not necessary. The effects of MGH alleviated the signs of local infection until their complete elimination. In eight out of nine cases, the non-healing wound was completely healed. MGH has antimicrobial, anti-inflammatory, and antioxidant effects in wounds of various aetiologies and forms an effective alternative for the use of antibiotics for treating locally infected wounds.

Citovat

HOLUBOVA, Adela, Lucie CHLUPACOVA, Lada CETLOVA, Niels A. J. CREMERS and Andrea POKORNÁ. Medical-Grade Honey as an Alternative Treatment for Antibiotics in Non-Healing Wounds-A Prospective Case Series. Antibiotics-Basel. BASEL: MDPI, 2021, vol. 10, No 8, p. 1-14. ISSN 2079-6382. Available from: https://dx.doi.org/10.3390/antibiotics10080918.

@article{1790038,
   author = {Holubova, Adela and Chlupacova, Lucie and Cetlova, Lada and Cremers, Niels A. J. and Pokorná, Andrea},
   article_location = {BASEL},
   article_number = {8},
   doi = {http://dx.doi.org/10.3390/antibiotics10080918},
   keywords = {medical grade honey; antibiotic replacement; infections; wounds; objective wound assessment},
   language = {eng},
   issn = {2079-6382},
   journal = {Antibiotics-Basel},
   title = {Medical-Grade Honey as an Alternative Treatment for Antibiotics in Non-Healing Wounds-A Prospective Case Series},
   url = {https://www.mdpi.com/2079-6382/10/8/918},
   volume = {10},
   year = {2021}
}

TY  - JOUR
ID  - 1790038
AU  - Holubova, Adela - Chlupacova, Lucie - Cetlova, Lada - Cremers, Niels A. J. - Pokorná, Andrea
PY  - 2021
TI  - Medical-Grade Honey as an Alternative Treatment for Antibiotics in Non-Healing Wounds-A Prospective Case Series
JF  - Antibiotics-Basel
VL  - 10
IS  - 8
SP  - 1-14
EP  - 1-14
PB  - MDPI
SN  - 20796382
KW  - medical grade honey
KW  - antibiotic replacement
KW  - infections
KW  - wounds
KW  - objective wound assessment
UR  - https://www.mdpi.com/2079-6382/10/8/918
N2  - Non-healing wounds are usually colonised by various types of bacteria. An alternative to antibiotic treatment in patients with infected wounds with local signs of inflammation may be medical-grade honey (MGH), which favourably affects the healing process with its antimicrobial, antioxidant, anti-inflammatory, and immunomodulatory properties. The objective of this study was to evaluate the effect of MGH therapy on the healing process of non-healing wounds of various aetiologies and different wound colonisations. Prospective, observation-intervention case studies (n = 9) of patients with wounds of various aetiologies (venous leg ulcers, diabetic foot ulcers, surgical wound dehiscence) are presented. All wounds were treated with MGH and the healing trajectory was rigorously and objectively monitored. In all cases, pain, odour, and exudation were quickly resolved, which led to an improvement in the quality of life of patients. Despite the proven bacterial microflora in wounds, antibiotic treatment was not necessary. The effects of MGH alleviated the signs of local infection until their complete elimination. In eight out of nine cases, the non-healing wound was completely healed. MGH has antimicrobial, anti-inflammatory, and antioxidant effects in wounds of various aetiologies and forms an effective alternative for the use of antibiotics for treating locally infected wounds.
ER  -

HOLUBOVA, Adela, Lucie CHLUPACOVA, Lada CETLOVA, Niels A. J. CREMERS and Andrea POKORNÁ. Medical-Grade Honey as an Alternative Treatment for Antibiotics in Non-Healing Wounds-A Prospective Case Series. \textit{Antibiotics-Basel}. BASEL: MDPI, 2021, vol.~10, No~8, p.~1-14. ISSN~2079-6382. Available from: https://dx.doi.org/10.3390/antibiotics10080918.

Detailed Information on Publication Record