HOLUBOVA, Adela, Lucie CHLUPACOVA, Lada CETLOVA, Niels A. J. CREMERS and Andrea POKORNÁ. Medical-Grade Honey as an Alternative Treatment for Antibiotics in Non-Healing Wounds-A Prospective Case Series. Antibiotics-Basel. BASEL: MDPI, vol. 10, No 8, p. 1-14. ISSN 2079-6382. doi:10.3390/antibiotics10080918. 2021.
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Basic information
Original name Medical-Grade Honey as an Alternative Treatment for Antibiotics in Non-Healing Wounds-A Prospective Case Series
Authors HOLUBOVA, Adela (203 Czech Republic, guarantor), Lucie CHLUPACOVA (203 Czech Republic), Lada CETLOVA (203 Czech Republic), Niels A. J. CREMERS (528 Netherlands) and Andrea POKORNÁ (203 Czech Republic, belonging to the institution).
Edition Antibiotics-Basel, BASEL, MDPI, 2021, 2079-6382.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30104 Pharmacology and pharmacy
Country of publisher Switzerland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 5.222
RIV identification code RIV/00216224:14110/21:00122262
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.3390/antibiotics10080918
UT WoS 000688588000001
Keywords in English medical grade honey; antibiotic replacement; infections; wounds; objective wound assessment
Tags 14110611, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 6/9/2021 12:02.
Abstract
Non-healing wounds are usually colonised by various types of bacteria. An alternative to antibiotic treatment in patients with infected wounds with local signs of inflammation may be medical-grade honey (MGH), which favourably affects the healing process with its antimicrobial, antioxidant, anti-inflammatory, and immunomodulatory properties. The objective of this study was to evaluate the effect of MGH therapy on the healing process of non-healing wounds of various aetiologies and different wound colonisations. Prospective, observation-intervention case studies (n = 9) of patients with wounds of various aetiologies (venous leg ulcers, diabetic foot ulcers, surgical wound dehiscence) are presented. All wounds were treated with MGH and the healing trajectory was rigorously and objectively monitored. In all cases, pain, odour, and exudation were quickly resolved, which led to an improvement in the quality of life of patients. Despite the proven bacterial microflora in wounds, antibiotic treatment was not necessary. The effects of MGH alleviated the signs of local infection until their complete elimination. In eight out of nine cases, the non-healing wound was completely healed. MGH has antimicrobial, anti-inflammatory, and antioxidant effects in wounds of various aetiologies and forms an effective alternative for the use of antibiotics for treating locally infected wounds.
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