NAChRDB: A Web Resource of Structure–Function Annotations to
Unravel the Allostery of Nicotinic Acetylcholine Receptors

J 2021

NAChRDB: A Web Resource of Structure–Function Annotations to Unravel the Allostery of Nicotinic Acetylcholine Receptors

CHARESHNEU, Aliaksei, Purbaj PANT, Ravi José Tristao RAMOS, David SEHNAL, Tuğrul GÖKBEL et. al.

Basic information

Original name

NAChRDB: A Web Resource of Structure–Function Annotations to Unravel the Allostery of Nicotinic Acetylcholine Receptors

Authors

CHARESHNEU, Aliaksei (112 Belarus, guarantor, belonging to the institution), Purbaj PANT (524 Nepal, belonging to the institution), Ravi José Tristao RAMOS (76 Brazil, belonging to the institution), David SEHNAL (203 Czech Republic, belonging to the institution), Tuğrul GÖKBEL (792 Turkey), Crina-Maria IONESCU (642 Romania, belonging to the institution) and Jaroslav KOČA (203 Czech Republic, belonging to the institution)

Edition

ACS Omega, American Chemical Society, 2021, 2470-1343

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10608 Biochemistry and molecular biology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.132

RIV identification code

RIV/00216224:14740/21:00122276

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1021/acsomega.1c00817

UT WoS

000696531700003

Keywords in English

Amines; Biological databases; Chemical structure; Sequence alignment; Receptors

Abstract

V originále

Nicotinic acetylcholine receptors (nAChRs) comprise a large and ancient family of allosteric ion channels mediating synaptic transmission. The vast knowledge about nAChRs has become difficult to navigate. NAChRDB is a web-accessible resource of curated residue-level functional annotations of neuromuscular nAChRs. Interactive three-dimensional (3D) visualization and sequence alignment give further context to this rich and growing collection of experimental observations and computational predictions. NAChRDB is freely available at https://crocodile.ncbr.muni.cz/Apps/NAChRDB/, with interactive tutorials and regular updates to the content and web interface. No installation or user registration is required. NAChRDB is accessible through any modern internet browser on desktops and mobile devices. By providing immediate and systematic access to practical knowledge gained through decades of research, NAChRDB represents a powerful educational tool and helps guide discovery by revealing gaps in current knowledge and aiding the interpretation of results of molecular and structural biology experiments or computational studies.

Links

LM2018131, research and development project

Name: Česká národní infrastruktura pro biologická data (Acronym: ELIXIR-CZ)

Investor: Ministry of Education, Youth and Sports of the CR, Czech National Infrastructure for Biological Data

LQ1601, research and development project

Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

CHARESHNEU, Aliaksei, Purbaj PANT, Ravi José Tristao RAMOS, David SEHNAL, Tuğrul GÖKBEL, Crina-Maria IONESCU and Jaroslav KOČA. NAChRDB: A Web Resource of Structure–Function Annotations to Unravel the Allostery of Nicotinic Acetylcholine Receptors. ACS Omega. American Chemical Society, 2021, vol. 6, No 36, p. 23023-23027. ISSN 2470-1343. Available from: https://dx.doi.org/10.1021/acsomega.1c00817.

@article{1790264,
   author = {Chareshneu, Aliaksei and Pant, Purbaj and Ramos, Ravi José Tristao and Sehnal, David and Gökbel, Tuğrul and Ionescu, CrinaandMaria and Koča, Jaroslav},
   article_number = {36},
   doi = {http://dx.doi.org/10.1021/acsomega.1c00817},
   keywords = {Amines; Biological databases; Chemical structure; Sequence alignment; Receptors},
   language = {eng},
   issn = {2470-1343},
   journal = {ACS Omega},
   title = {NAChRDB: A Web Resource of Structure–Function Annotations to Unravel the Allostery of Nicotinic Acetylcholine Receptors},
   url = {https://pubs.acs.org/doi/10.1021/acsomega.1c00817},
   volume = {6},
   year = {2021}
}

TY  - JOUR
ID  - 1790264
AU  - Chareshneu, Aliaksei - Pant, Purbaj - Ramos, Ravi José Tristao - Sehnal, David - Gökbel, Tuğrul - Ionescu, Crina-Maria - Koča, Jaroslav
PY  - 2021
TI  - NAChRDB: A Web Resource of Structure–Function Annotations to Unravel the Allostery of Nicotinic Acetylcholine Receptors
JF  - ACS Omega
VL  - 6
IS  - 36
SP  - 23023-23027
EP  - 23023-23027
PB  - American Chemical Society
SN  - 24701343
KW  - Amines
KW  - Biological databases
KW  - Chemical structure
KW  - Sequence alignment
KW  - Receptors
UR  - https://pubs.acs.org/doi/10.1021/acsomega.1c00817
N2  - Nicotinic acetylcholine receptors (nAChRs) comprise a large and ancient family of allosteric ion channels mediating synaptic transmission. The vast knowledge about nAChRs has become difficult to navigate. NAChRDB is a web-accessible resource of curated residue-level functional annotations of neuromuscular nAChRs. Interactive three-dimensional (3D) visualization and sequence alignment give further context to this rich and growing collection of experimental observations and computational predictions. NAChRDB is freely available at https://crocodile.ncbr.muni.cz/Apps/NAChRDB/, with interactive tutorials and regular updates to the content and web interface. No installation or user registration is required. NAChRDB is accessible through any modern internet browser on desktops and mobile devices. By providing immediate and systematic access to practical knowledge gained through decades of research, NAChRDB represents a powerful educational tool and helps guide discovery by revealing gaps in current knowledge and aiding the interpretation of results of molecular and structural biology experiments or computational studies.
ER  -

CHARESHNEU, Aliaksei, Purbaj PANT, Ravi José Tristao RAMOS, David SEHNAL, Tuğrul GÖKBEL, Crina-Maria IONESCU and Jaroslav KOČA. NAChRDB: A Web Resource of Structure–Function Annotations to Unravel the Allostery of Nicotinic Acetylcholine Receptors. \textit{ACS Omega}. American Chemical Society, 2021, vol.~6, No~36, p.~23023-23027. ISSN~2470-1343. Available from: https://dx.doi.org/10.1021/acsomega.1c00817.

Detailed Information on Publication Record