NAChRDB: Interactive annotations to untangle allostery of
nicotinic acetylcholine receptor

a 2021

NAChRDB: Interactive annotations to untangle allostery of nicotinic acetylcholine receptor

CHARESHNEU, Aliaksei, Purbaj PANT, Ravi José TRISTÃO RAMOS, David SEHNAL, Tuğrul GÖKBEL et. al.

Basic information

Original name

NAChRDB: Interactive annotations to untangle allostery of nicotinic acetylcholine receptor

Authors

CHARESHNEU, Aliaksei, Purbaj PANT, Ravi José TRISTÃO RAMOS, David SEHNAL, Tuğrul GÖKBEL, Crina-Maria IONESCU and Jaroslav KOČA

Edition

VIZBI 2021 - 11th international meeting on Visualizing Biological Data, 2021

Other information

Language

English

Type of outcome

Konferenční abstrakt

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Organization unit

Central European Institute of Technology

Abstract

V originále

Nicotinic acetylcholine receptor (nAChR) is an ancient allosteric membrane protein mediating synaptic transmission. These prototypic pentameric ligand-gated ion channels are expressed in many tissues & species, being involved in cognition, metabolism, neuromuscular transmission, and many pathologies (myasthenia gravis, Parkinson & Alzheimer diseases, addictions). Since its isolation in 1970, studies produced >5000 publications with huge amounts of structural-functional data. However, cumulative residue-level knowledge on nAChRs is not systematically accessible. Scatteredness of literature data, aliases, various receptor types & residue numberings make it harder to summarize current knowledge and apply it efficiently to promote further discoveries. There is no single resource providing access to & visualization of such information. NACHRDB fills this gap, delivering relevant structural-functional data together with computational predictions of allosterically important residues, and facilitating its interpretation via interactive 3D visualization & sequence alignment. It can help to study allosteric regulation, reveal gaps in current knowledge, and guide further studies in the field.

Citovat

CHARESHNEU, Aliaksei, Purbaj PANT, Ravi José TRISTÃO RAMOS, David SEHNAL, Tuğrul GÖKBEL, Crina-Maria IONESCU and Jaroslav KOČA. NAChRDB: Interactive annotations to untangle allostery of nicotinic acetylcholine receptor. In VIZBI 2021 - 11th international meeting on Visualizing Biological Data. 2021.

@proceedings{1790350,
   author = {Chareshneu, Aliaksei and Pant, Purbaj and Tristão Ramos, Ravi José and Sehnal, David and Gökbel, Tuğrul and Ionescu, CrinaandMaria and Koča, Jaroslav},
   booktitle = {VIZBI 2021 - 11th international meeting on Visualizing Biological Data},
   language = {eng},
   title = {NAChRDB: Interactive annotations to untangle allostery of nicotinic acetylcholine receptor},
   url = {https://vizbi.org/Posters/2021/vA01},
   year = {2021}
}

TY  - CONF
ID  - 1790350
AU  - Chareshneu, Aliaksei - Pant, Purbaj - Tristão Ramos, Ravi José - Sehnal, David - Gökbel, Tuğrul - Ionescu, Crina-Maria - Koča, Jaroslav
PY  - 2021
TI  - NAChRDB: Interactive annotations to untangle allostery of nicotinic acetylcholine receptor
UR  - https://vizbi.org/Posters/2021/vA01
N2  - Nicotinic acetylcholine receptor (nAChR) is an ancient allosteric membrane protein mediating synaptic transmission. These prototypic pentameric ligand-gated ion channels are expressed in many tissues & species, being involved in cognition, metabolism, neuromuscular transmission, and many pathologies (myasthenia gravis, Parkinson & Alzheimer diseases, addictions). Since its isolation in 1970, studies produced >5000 publications with huge amounts of structural-functional data. However, cumulative residue-level knowledge on nAChRs is not systematically accessible. Scatteredness of literature data, aliases, various receptor types & residue numberings make it harder to summarize current knowledge and apply it efficiently to promote further discoveries. There is no single resource providing access to & visualization of such information. NACHRDB fills this gap, delivering relevant structural-functional data together with computational predictions of allosterically important residues, and facilitating its interpretation via interactive 3D visualization & sequence alignment. It can help to study allosteric regulation, reveal gaps in current knowledge, and guide further studies in the field.
ER  -

CHARESHNEU, Aliaksei, Purbaj PANT, Ravi José TRISTÃO RAMOS, David SEHNAL, Tuğrul GÖKBEL, Crina-Maria IONESCU and Jaroslav KOČA. NAChRDB: Interactive annotations to untangle allostery of nicotinic acetylcholine receptor. In \textit{VIZBI 2021 - 11th international meeting on Visualizing Biological Data}. 2021.

Detailed Information on Publication Record