NAChRDB: Interactive annotations to untangle allostery of nicotinic acetylcholine receptor

CHARESHNEU, Aliaksei, Purbaj PANT, Ravi José TRISTÃO RAMOS, David SEHNAL, Tuğrul GÖKBEL, Crina-Maria IONESCU and Jaroslav KOČA. NAChRDB: Interactive annotations to untangle allostery of nicotinic acetylcholine receptor. In VIZBI 2021 - 11th international meeting on Visualizing Biological Data. 2021.

Basic information

• Original name: NAChRDB: Interactive annotations to untangle allostery of nicotinic acetylcholine receptor
• Authors: CHARESHNEU, Aliaksei, Purbaj PANT, Ravi José TRISTÃO RAMOS, David SEHNAL, Tuğrul GÖKBEL, Crina-Maria IONESCU and Jaroslav KOČA.
• Edition: VIZBI 2021 - 11th international meeting on Visualizing Biological Data, 2021.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Organization unit: Central European Institute of Technology
• Tags: International impact

Abstract

Nicotinic acetylcholine receptor (nAChR) is an ancient allosteric membrane protein mediating synaptic transmission. These prototypic pentameric ligand-gated ion channels are expressed in many tissues & species, being involved in cognition, metabolism, neuromuscular transmission, and many pathologies (myasthenia gravis, Parkinson & Alzheimer diseases, addictions). Since its isolation in 1970, studies produced >5000 publications with huge amounts of structural-functional data. However, cumulative residue-level knowledge on nAChRs is not systematically accessible. Scatteredness of literature data, aliases, various receptor types & residue numberings make it harder to summarize current knowledge and apply it efficiently to promote further discoveries. There is no single resource providing access to & visualization of such information. NACHRDB fills this gap, delivering relevant structural-functional data together with computational predictions of allosterically important residues, and facilitating its interpretation via interactive 3D visualization & sequence alignment. It can help to study allosteric regulation, reveal gaps in current knowledge, and guide further studies in the field.