MRI Diffusion-Weighted Imaging to Measure Infarct Volume:
Assessment of Manual Segmentation Variability

J 2021

MRI Diffusion-Weighted Imaging to Measure Infarct Volume: Assessment of Manual Segmentation Variability

CIMFLOVÁ, Petra, Jiří KRÁL, Ondřej VOLNÝ, MacKenzie HORN, Piyush OJHA et. al.

Basic information

Original name

MRI Diffusion-Weighted Imaging to Measure Infarct Volume: Assessment of Manual Segmentation Variability

Authors

CIMFLOVÁ, Petra (203 Czech Republic, belonging to the institution), Jiří KRÁL (203 Czech Republic, belonging to the institution), Ondřej VOLNÝ (203 Czech Republic), MacKenzie HORN, Piyush OJHA, Martin CABAL (203 Czech Republic), Linda MACHOVÁ (203 Czech Republic, belonging to the institution), Jaroslav HAVELKA (203 Czech Republic), Tomas JONSZTA (203 Czech Republic), Michal BAR (203 Czech Republic) and Wu QIU (guarantor)

Edition

Journal of Neuroimaging, Hoboken, Wiley-Blackwell, 2021, 1051-2284

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30224 Radiology, nuclear medicine and medical imaging

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.324

RIV identification code

RIV/00216224:14110/21:00122326

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1111/jon.12850

UT WoS

000634712300001

Keywords in English

Ischemic lesion volume; manual segmentation variability; MRI‐ DWI; stroke imaging

Abstract

V originále

BACKGROUND AND PURPOSE Manual segmentation of infarct volume on follow-up MRI diffusion-weighted imaging (MRI-DWI) is considered the gold standard but is prone to rater variability. We assess the variability of manual segmentations of MRI-DWI infarct volume. METHODS Consecutive patients (May 2018 to May 2019) with the anterior circulation stroke and endovascularly treated were enrolled. All patients underwent 24- to 32-hour follow-up MRI. Three users manually segmented DWI infarct volumes slice by slice twice. The reference standard of DWI infarct volume was generated by the STAPLE algorithm. Intra- and interrater reliability was evaluated using the intraclass correlation coefficient (ICC) by comparing manual segmentations with the reference standard. Spatial measurements were evaluated using metrics of the Dice similarity coefficient (DSC). Volumetric measurements were compared using the lesion volume. RESULTS The dataset consisted of 44 patients, mean (SD) age was 70.1 years (+/- 10.3), 43% were women, and median baseline NIHSS score was 16. Among three users, the mean DSC for MRI-DWI infarct volume segmentations ranged from 80.6% +/- 11.7% to 88.6% +/- 7.5%, and the mean absolute volume difference was 2.8 +/- 6.8 to 13.0 +/- 14.0 ml. Interrater ICC among the users for DSC and infarct volume was .86 (95% confidence interval [95% CI]: .78-.91) and .997 (95% CI: .995-.998). Intrarater ICC for the three users was .83 (95% CI: .69-.93), .84 (95% CI: .72-.91), and .80 (95% CI: .64-.89) for DSC, and .99 (95% CI: .987-.996), .991 (95% CI: .983-.995), and .996 (95% CI: .993-.998) for infarct volume. CONCLUSIONS Manual segmentation of infarct volume on follow-up MRI-DWI shows excellent agreement and good spatial overlap with the reference standard, suggesting its usefulness for measuring infarct volume on 24- to 32-hour MRI-DWI.

Citovat

CIMFLOVÁ, Petra, Jiří KRÁL, Ondřej VOLNÝ, MacKenzie HORN, Piyush OJHA, Martin CABAL, Linda MACHOVÁ, Jaroslav HAVELKA, Tomas JONSZTA, Michal BAR and Wu QIU. MRI Diffusion-Weighted Imaging to Measure Infarct Volume: Assessment of Manual Segmentation Variability. Journal of Neuroimaging. Hoboken: Wiley-Blackwell, 2021, vol. 31, No 3, p. 541-550. ISSN 1051-2284. Available from: https://dx.doi.org/10.1111/jon.12850.

@article{1791738,
   author = {Cimflová, Petra and Král, Jiří and Volný, Ondřej and Horn, MacKenzie and Ojha, Piyush and Cabal, Martin and Machová, Linda and Havelka, Jaroslav and Jonszta, Tomas and Bar, Michal and Qiu, Wu},
   article_location = {Hoboken},
   article_number = {3},
   doi = {http://dx.doi.org/10.1111/jon.12850},
   keywords = {Ischemic lesion volume; manual segmentation variability; MRI‐ DWI; stroke imaging},
   language = {eng},
   issn = {1051-2284},
   journal = {Journal of Neuroimaging},
   title = {MRI Diffusion-Weighted Imaging to Measure Infarct Volume: Assessment of Manual Segmentation Variability},
   url = {https://www.scopus.com/record/display.uri?eid=2-s2.0-85103369524&origin=resultslist&sort=plf-f&src=s&sid=77b4291f6e2f8d22d9e30e8ce1095dfd&sot=b&sdt=b&sl=22&s=DOI%2810.1111%2fjon.12850%29&relpos=0&citeCnt=0&searchTerm=},
   volume = {31},
   year = {2021}
}

TY  - JOUR
ID  - 1791738
AU  - Cimflová, Petra - Král, Jiří - Volný, Ondřej - Horn, MacKenzie - Ojha, Piyush - Cabal, Martin - Machová, Linda - Havelka, Jaroslav - Jonszta, Tomas - Bar, Michal - Qiu, Wu
PY  - 2021
TI  - MRI Diffusion-Weighted Imaging to Measure Infarct Volume: Assessment of Manual Segmentation Variability
JF  - Journal of Neuroimaging
VL  - 31
IS  - 3
SP  - 541-550
EP  - 541-550
PB  - Wiley-Blackwell
SN  - 10512284
KW  - Ischemic lesion volume
KW  - manual segmentation variability
KW  - MRI‐ DWI
KW  - stroke imaging
UR  - https://www.scopus.com/record/display.uri?eid=2-s2.0-85103369524&origin=resultslist&sort=plf-f&src=s&sid=77b4291f6e2f8d22d9e30e8ce1095dfd&sot=b&sdt=b&sl=22&s=DOI%2810.1111%2fjon.12850%29&relpos=0&citeCnt=0&searchTerm=
N2  - BACKGROUND AND PURPOSE Manual segmentation of infarct volume on follow-up MRI diffusion-weighted imaging (MRI-DWI) is considered the gold standard but is prone to rater variability. We assess the variability of manual segmentations of MRI-DWI infarct volume. METHODS Consecutive patients (May 2018 to May 2019) with the anterior circulation stroke and endovascularly treated were enrolled. All patients underwent 24- to 32-hour follow-up MRI. Three users manually segmented DWI infarct volumes slice by slice twice. The reference standard of DWI infarct volume was generated by the STAPLE algorithm. Intra- and interrater reliability was evaluated using the intraclass correlation coefficient (ICC) by comparing manual segmentations with the reference standard. Spatial measurements were evaluated using metrics of the Dice similarity coefficient (DSC). Volumetric measurements were compared using the lesion volume. RESULTS The dataset consisted of 44 patients, mean (SD) age was 70.1 years (+/- 10.3), 43% were women, and median baseline NIHSS score was 16. Among three users, the mean DSC for MRI-DWI infarct volume segmentations ranged from 80.6% +/- 11.7% to 88.6% +/- 7.5%, and the mean absolute volume difference was 2.8 +/- 6.8 to 13.0 +/- 14.0 ml. Interrater ICC among the users for DSC and infarct volume was .86 (95% confidence interval [95% CI]: .78-.91) and .997 (95% CI: .995-.998). Intrarater ICC for the three users was .83 (95% CI: .69-.93), .84 (95% CI: .72-.91), and .80 (95% CI: .64-.89) for DSC, and .99 (95% CI: .987-.996), .991 (95% CI: .983-.995), and .996 (95% CI: .993-.998) for infarct volume. CONCLUSIONS Manual segmentation of infarct volume on follow-up MRI-DWI shows excellent agreement and good spatial overlap with the reference standard, suggesting its usefulness for measuring infarct volume on 24- to 32-hour MRI-DWI.
ER  -

CIMFLOVÁ, Petra, Jiří KRÁL, Ondřej VOLNÝ, MacKenzie HORN, Piyush OJHA, Martin CABAL, Linda MACHOVÁ, Jaroslav HAVELKA, Tomas JONSZTA, Michal BAR and Wu QIU. MRI Diffusion-Weighted Imaging to Measure Infarct Volume: Assessment of Manual Segmentation Variability. \textit{Journal of Neuroimaging}. Hoboken: Wiley-Blackwell, 2021, vol.~31, No~3, p.~541-550. ISSN~1051-2284. Available from: https://dx.doi.org/10.1111/jon.12850.

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