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@article{1793034,
author = {Tomandlová, Marie and Pařenica, Jiří and Lokaj, Petr and Ondrúš, Tomáš and Kala, Petr and Miklíková, Marie and Helánová, Kateřina and Helán, Martin and Maláska, Jan and Benešová, Klára and Jarkovský, Jiří and Pávková Goldbergová, Monika and Tomandl, Josef},
article_location = {NEW YORK},
article_number = {October 2021},
doi = {http://dx.doi.org/10.1016/j.freeradbiomed.2021.07.040},
keywords = {Cardiogenic shock; Reactive oxygen species; Oxidised guanine species; 8-Hydroxy-2 '-deoxyguanosine; Malondialdehyde; FRAP; Cu/Zn-superoxide dismutase; Glutathione peroxidase; Glutathione},
language = {eng},
issn = {0891-5849},
journal = {Free Radical Biology and Medicine},
title = {Prognostic value of oxidative stress in patients with acute myocardial infarction complicated by cardiogenic shock: A prospective cohort study},
url = {https://www.sciencedirect.com/science/article/pii/S0891584921004391?via%3Dihub},
volume = {174},
year = {2021}
}
TY - JOUR
ID - 1793034
AU - Tomandlová, Marie - Pařenica, Jiří - Lokaj, Petr - Ondrúš, Tomáš - Kala, Petr - Miklíková, Marie - Helánová, Kateřina - Helán, Martin - Maláska, Jan - Benešová, Klára - Jarkovský, Jiří - Pávková Goldbergová, Monika - Tomandl, Josef
PY - 2021
TI - Prognostic value of oxidative stress in patients with acute myocardial infarction complicated by cardiogenic shock: A prospective cohort study
JF - Free Radical Biology and Medicine
VL - 174
IS - October 2021
SP - 66-72
EP - 66-72
PB - ELSEVIER SCIENCE INC
SN - 08915849
KW - Cardiogenic shock
KW - Reactive oxygen species
KW - Oxidised guanine species
KW - 8-Hydroxy-2 '-deoxyguanosine
KW - Malondialdehyde
KW - FRAP
KW - Cu/Zn-superoxide dismutase
KW - Glutathione peroxidase
KW - Glutathione
UR - https://www.sciencedirect.com/science/article/pii/S0891584921004391?via%3Dihub
N2 - Introduction: Cardiogenic shock is a frequent complication of acute myocardial infarction. Similar to ischemia/reperfusion injury, excessive production of reactive oxygen species can be expected in those who experience cardiogenic shock. The aims of this study were to describe the extent and time course of oxidative stress and evaluate the prognostic value of oxidative stress markers in patients who experienced ST-segment elevation myocardial infarction (STEMI) complicated by cardiogenic shock. Methods: Plasma/serum levels of selected biomarkers of oxidative stress (oxidised guanine species (OGS), malondialdehyde, and glutathione peroxidase 3) and markers, which simultaneously reflect severe cellular damage (ferric ion reducing antioxidant power (FRAP), Cu/Zn-superoxide dismutase (SOD), and glutathione) were measured seven times per week in a prospective cohort of 82 patients with STEMI complicated by cardiogenic shock. Results: We found elevated OGS levels in patients who died during three months, which persisted significantly increased the next 12 h compared to surviving patients. A similar time course pattern also exhibited concentrations of FRAP and SOD. The other markers did not change significantly and did not show differences between surviving and non-surviving patients during the monitored period. In addition, a strong relationship between OGS, FRAP, and SOD levels (on admission and 12 h after admission) and 3-month mortality was found. Conclusion: Levels of OGS, FRAP, and SOD within 12 h after hospital admission were revealed as early predictors of the adverse development of STEMI complicated by cardiogenic shock.
ER -
TOMANDLOVÁ, Marie, Jiří PAŘENICA, Petr LOKAJ, Tomáš ONDRÚŠ, Petr KALA, Marie MIKLÍKOVÁ, Kateřina HELÁNOVÁ, Martin HELÁN, Jan MALÁSKA, Klára BENEŠOVÁ, Jiří JARKOVSKÝ, Monika PÁVKOVÁ GOLDBERGOVÁ and Josef TOMANDL. Prognostic value of oxidative stress in patients with acute myocardial infarction complicated by cardiogenic shock: A prospective cohort study. \textit{Free Radical Biology and Medicine}. NEW YORK: ELSEVIER SCIENCE INC, 2021, vol.~174, October 2021, p.~66-72. ISSN~0891-5849. Available from: https://dx.doi.org/10.1016/j.freeradbiomed.2021.07.040.
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