Detailed Information on Publication Record
2021
Prognostic value of oxidative stress in patients with acute myocardial infarction complicated by cardiogenic shock: A prospective cohort study
TOMANDLOVÁ, Marie, Jiří PAŘENICA, Petr LOKAJ, Tomáš ONDRÚŠ, Petr KALA et. al.Basic information
Original name
Prognostic value of oxidative stress in patients with acute myocardial infarction complicated by cardiogenic shock: A prospective cohort study
Authors
TOMANDLOVÁ, Marie (203 Czech Republic, belonging to the institution), Jiří PAŘENICA (203 Czech Republic, belonging to the institution), Petr LOKAJ (203 Czech Republic, belonging to the institution), Tomáš ONDRÚŠ (703 Slovakia, belonging to the institution), Petr KALA (203 Czech Republic, belonging to the institution), Marie MIKLÍKOVÁ (203 Czech Republic, belonging to the institution), Kateřina HELÁNOVÁ (203 Czech Republic), Martin HELÁN (203 Czech Republic), Jan MALÁSKA (203 Czech Republic, belonging to the institution), Klára BENEŠOVÁ (203 Czech Republic, belonging to the institution), Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution), Monika PÁVKOVÁ GOLDBERGOVÁ (203 Czech Republic, belonging to the institution) and Josef TOMANDL (203 Czech Republic, guarantor, belonging to the institution)
Edition
Free Radical Biology and Medicine, NEW YORK, ELSEVIER SCIENCE INC, 2021, 0891-5849
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10608 Biochemistry and molecular biology
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 8.101
RIV identification code
RIV/00216224:14110/21:00122380
Organization unit
Faculty of Medicine
UT WoS
000692554900002
Keywords in English
Cardiogenic shock; Reactive oxygen species; Oxidised guanine species; 8-Hydroxy-2 '-deoxyguanosine; Malondialdehyde; FRAP; Cu/Zn-superoxide dismutase; Glutathione peroxidase; Glutathione
Tags
International impact, Reviewed
Změněno: 20/9/2021 12:40, Mgr. Tereza Miškechová
Abstract
V originále
Introduction: Cardiogenic shock is a frequent complication of acute myocardial infarction. Similar to ischemia/reperfusion injury, excessive production of reactive oxygen species can be expected in those who experience cardiogenic shock. The aims of this study were to describe the extent and time course of oxidative stress and evaluate the prognostic value of oxidative stress markers in patients who experienced ST-segment elevation myocardial infarction (STEMI) complicated by cardiogenic shock. Methods: Plasma/serum levels of selected biomarkers of oxidative stress (oxidised guanine species (OGS), malondialdehyde, and glutathione peroxidase 3) and markers, which simultaneously reflect severe cellular damage (ferric ion reducing antioxidant power (FRAP), Cu/Zn-superoxide dismutase (SOD), and glutathione) were measured seven times per week in a prospective cohort of 82 patients with STEMI complicated by cardiogenic shock. Results: We found elevated OGS levels in patients who died during three months, which persisted significantly increased the next 12 h compared to surviving patients. A similar time course pattern also exhibited concentrations of FRAP and SOD. The other markers did not change significantly and did not show differences between surviving and non-surviving patients during the monitored period. In addition, a strong relationship between OGS, FRAP, and SOD levels (on admission and 12 h after admission) and 3-month mortality was found. Conclusion: Levels of OGS, FRAP, and SOD within 12 h after hospital admission were revealed as early predictors of the adverse development of STEMI complicated by cardiogenic shock.