Prognostic value of high-sensitivity cardiac troponin I in
heart failure patients with mid-range and reduced ejection
fraction

J 2021

Prognostic value of high-sensitivity cardiac troponin I in heart failure patients with mid-range and reduced ejection fraction

LOKAJ, Petr, Jindřich ŠPINAR, Lenka ŠPINAROVÁ, Filip MALEK, Ondřej LUDKA et. al.

Basic information

Original name

Prognostic value of high-sensitivity cardiac troponin I in heart failure patients with mid-range and reduced ejection fraction

Authors

LOKAJ, Petr (203 Czech Republic, belonging to the institution), Jindřich ŠPINAR (203 Czech Republic, belonging to the institution), Lenka ŠPINAROVÁ (203 Czech Republic, belonging to the institution), Filip MALEK (203 Czech Republic), Ondřej LUDKA (203 Czech Republic, belonging to the institution), Jan KREJČÍ (203 Czech Republic, belonging to the institution), Petr OSTADAL (203 Czech Republic), Dagmar VONDRAKOVA (203 Czech Republic), Karel LÁBR (203 Czech Republic, belonging to the institution), Monika ŠPINAROVÁ (203 Czech Republic, belonging to the institution), Monika PÁVKOVÁ GOLDBERGOVÁ (203 Czech Republic, belonging to the institution), Marie MIKLÍKOVÁ (203 Czech Republic, belonging to the institution), Kateřina HELÁNOVÁ (203 Czech Republic, belonging to the institution), Ilona PARENICOVA (203 Czech Republic), Vladimír JAKUBO (703 Slovakia, belonging to the institution), Klára BENEŠOVÁ (203 Czech Republic, belonging to the institution), Roman MIKLIK (203 Czech Republic), Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution), Tomáš ONDRÚŠ (703 Slovakia, guarantor, belonging to the institution) and Jiří PAŘENICA (203 Czech Republic, belonging to the institution)

Edition

Plos one, San Francisco, Public Library Science, 2021, 1932-6203

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10700 1.7 Other natural sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.752

RIV identification code

RIV/00216224:14110/21:00122391

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1371/journal.pone.0255271

UT WoS

000685248600043

Keywords in English

high-sensitivity cardiac troponin I; heart failure patients; ejection fraction

Abstract

V originále

Background The identification of high-risk heart failure (HF) patients makes it possible to intensify their treatment. Our aim was to determine the prognostic value of a newly developed, high-sensitivity troponin I assay (Atellica(R), Siemens Healthcare Diagnostics) for patients with HF with reduced ejection fraction (HFrEF; LVEF < 40%) and HF with mid-range EF (HFmrEF) (LVEF 40%-49%). Methods and results A total of 520 patients with HFrEF and HFmrEF were enrolled in this study. Two-year all-cause mortality, heart transplantation, and/or left ventricular assist device implantation were defined as the primary endpoints (EP). A logistic regression analysis was used for the identification of predictors and development of multivariable models. The EP occurred in 14% of the patients, and these patients had higher NT-proBNP (1,950 vs. 518 ng/l; p < 0.001) and hs-cTnI (34 vs. 17 ng/l, p < 0.001) levels. C-statistics demonstrated that the optimal cut-off value for the hs-cTnI level was 17 ng/l (AUC 0.658, p < 0.001). Described by the AUC, the discriminatory power of the multivariable model (NYHA > II, NT-proBNP, hs-cTnI and urea) was 0.823 (p < 0.001). Including heart failure hospitalization as the component of the combined secondary endpoint leads to a diminished predictive power of increased hs-cTnI. Conclusion hs-cTnI levels >= 17 ng/l represent an independent increased risk of an adverse prognosis for patients with HFrEF and HFmrEF. Determining a patient's hs-cTnI level adds prognostic value to NT-proBNP and clinical parameters.

Citovat

LOKAJ, Petr, Jindřich ŠPINAR, Lenka ŠPINAROVÁ, Filip MALEK, Ondřej LUDKA, Jan KREJČÍ, Petr OSTADAL, Dagmar VONDRAKOVA, Karel LÁBR, Monika ŠPINAROVÁ, Monika PÁVKOVÁ GOLDBERGOVÁ, Marie MIKLÍKOVÁ, Kateřina HELÁNOVÁ, Ilona PARENICOVA, Vladimír JAKUBO, Klára BENEŠOVÁ, Roman MIKLIK, Jiří JARKOVSKÝ, Tomáš ONDRÚŠ and Jiří PAŘENICA. Prognostic value of high-sensitivity cardiac troponin I in heart failure patients with mid-range and reduced ejection fraction. Plos one. San Francisco: Public Library Science, 2021, vol. 16, No 7, p. 1-14. ISSN 1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0255271.

@article{1793185,
   author = {Lokaj, Petr and Špinar, Jindřich and Špinarová, Lenka and Malek, Filip and Ludka, Ondřej and Krejčí, Jan and Ostadal, Petr and Vondrakova, Dagmar and Lábr, Karel and Špinarová, Monika and Pávková Goldbergová, Monika and Miklíková, Marie and Helánová, Kateřina and Parenicova, Ilona and Jakubo, Vladimír and Benešová, Klára and Miklik, Roman and Jarkovský, Jiří and Ondrúš, Tomáš and Pařenica, Jiří},
   article_location = {San Francisco},
   article_number = {7},
   doi = {http://dx.doi.org/10.1371/journal.pone.0255271},
   keywords = {high-sensitivity cardiac troponin I; heart failure patients; ejection fraction},
   language = {eng},
   issn = {1932-6203},
   journal = {Plos one},
   title = {Prognostic value of high-sensitivity cardiac troponin I in heart failure patients with mid-range and reduced ejection fraction},
   url = {https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0255271},
   volume = {16},
   year = {2021}
}

TY  - JOUR
ID  - 1793185
AU  - Lokaj, Petr - Špinar, Jindřich - Špinarová, Lenka - Malek, Filip - Ludka, Ondřej - Krejčí, Jan - Ostadal, Petr - Vondrakova, Dagmar - Lábr, Karel - Špinarová, Monika - Pávková Goldbergová, Monika - Miklíková, Marie - Helánová, Kateřina - Parenicova, Ilona - Jakubo, Vladimír - Benešová, Klára - Miklik, Roman - Jarkovský, Jiří - Ondrúš, Tomáš - Pařenica, Jiří
PY  - 2021
TI  - Prognostic value of high-sensitivity cardiac troponin I in heart failure patients with mid-range and reduced ejection fraction
JF  - Plos one
VL  - 16
IS  - 7
SP  - 1-14
EP  - 1-14
PB  - Public Library Science
SN  - 19326203
KW  - high-sensitivity cardiac troponin I
KW  - heart failure patients
KW  - ejection fraction
UR  - https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0255271
N2  - Background The identification of high-risk heart failure (HF) patients makes it possible to intensify their treatment. Our aim was to determine the prognostic value of a newly developed, high-sensitivity troponin I assay (Atellica(R), Siemens Healthcare Diagnostics) for patients with HF with reduced ejection fraction (HFrEF; LVEF < 40%) and HF with mid-range EF (HFmrEF) (LVEF 40%-49%). Methods and results A total of 520 patients with HFrEF and HFmrEF were enrolled in this study. Two-year all-cause mortality, heart transplantation, and/or left ventricular assist device implantation were defined as the primary endpoints (EP). A logistic regression analysis was used for the identification of predictors and development of multivariable models. The EP occurred in 14% of the patients, and these patients had higher NT-proBNP (1,950 vs. 518 ng/l; p < 0.001) and hs-cTnI (34 vs. 17 ng/l, p < 0.001) levels. C-statistics demonstrated that the optimal cut-off value for the hs-cTnI level was 17 ng/l (AUC 0.658, p < 0.001). Described by the AUC, the discriminatory power of the multivariable model (NYHA > II, NT-proBNP, hs-cTnI and urea) was 0.823 (p < 0.001). Including heart failure hospitalization as the component of the combined secondary endpoint leads to a diminished predictive power of increased hs-cTnI. Conclusion hs-cTnI levels >= 17 ng/l represent an independent increased risk of an adverse prognosis for patients with HFrEF and HFmrEF. Determining a patient's hs-cTnI level adds prognostic value to NT-proBNP and clinical parameters.
ER  -

LOKAJ, Petr, Jindřich ŠPINAR, Lenka ŠPINAROVÁ, Filip MALEK, Ondřej LUDKA, Jan KREJČÍ, Petr OSTADAL, Dagmar VONDRAKOVA, Karel LÁBR, Monika ŠPINAROVÁ, Monika PÁVKOVÁ GOLDBERGOVÁ, Marie MIKLÍKOVÁ, Kateřina HELÁNOVÁ, Ilona PARENICOVA, Vladimír JAKUBO, Klára BENEŠOVÁ, Roman MIKLIK, Jiří JARKOVSKÝ, Tomáš ONDRÚŠ and Jiří PAŘENICA. Prognostic value of high-sensitivity cardiac troponin I in heart failure patients with mid-range and reduced ejection fraction. \textit{Plos one}. San Francisco: Public Library Science, 2021, vol.~16, No~7, p.~1-14. ISSN~1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0255271.

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