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@article{1793187,
author = {Andrašina, Tomáš and Rohan, Tomáš and Pánek, Jiří and Kovalčíková, Petra and Kunovský, Lumír and Ostřížková, Lenka and Válek, Vlastimil},
article_location = {Ireland},
article_number = {September 2021},
doi = {http://dx.doi.org/10.1016/j.ejrad.2021.109830},
keywords = {Endoluminal ablation; Intraductal ablation; Bile duct stenosis; Radiofrequency ablation; Biliary metal stent},
language = {eng},
issn = {0720-048X},
journal = {European journal of radiology},
title = {The combination of endoluminal radiofrequency ablation and metal stent implantation for the treatment of malignant biliary stenosis-Randomized study},
url = {https://www.sciencedirect.com/science/article/pii/S0720048X21003119?via%3Dihub},
volume = {142},
year = {2021}
}
TY - JOUR
ID - 1793187
AU - Andrašina, Tomáš - Rohan, Tomáš - Pánek, Jiří - Kovalčíková, Petra - Kunovský, Lumír - Ostřížková, Lenka - Válek, Vlastimil
PY - 2021
TI - The combination of endoluminal radiofrequency ablation and metal stent implantation for the treatment of malignant biliary stenosis-Randomized study
JF - European journal of radiology
VL - 142
IS - September 2021
SP - 1-7
EP - 1-7
PB - Elsevier Science Ireland Ltd
SN - 0720048X
KW - Endoluminal ablation
KW - Intraductal ablation
KW - Bile duct stenosis
KW - Radiofrequency ablation
KW - Biliary metal stent
UR - https://www.sciencedirect.com/science/article/pii/S0720048X21003119?via%3Dihub
N2 - Purpose: To analyse whether endobiliary radiofrequency ablation prior metal stent insertion in malignant biliary stenosis show improved survival or stent patency. Methods: 76 patients with histologically proven malignant biliary stenosis have been enrolled in a prospective, randomized study. In control arm, 40 patients underwent self-expandable metal stent insertion. In experimental arm, the endoluminal ablation with a bipolar radiofrequency catheter was performed immediately before stent insertion. A subgroup analysis of cholangiocarcinoma was performed (22 vs 21 patients). The objective of the study was to determine the rate of complications, duration of the stent patency and the survival of patients (Kaplan-Meier analysis). Results: No major complications related to the stent insertion and the endoluminal ablation were found. The mean primary stent patency was 5.2 (95% CI 0.7-12.8) vs 4.8 months (95% CI 0.8-18.2) months (p = 0.79) in control and experimental group, respectively, in the subgroup analysis with cholangiocarcinoma 4.5 (95% CI 0.8-10.3) and 9.6 (95% CI 5.2-11.2) months (p = 0.029). The median survival since the insertion of the stent was 6.8 (95 %CI 3.0-10.6) vs 5.2 (95 %CI 2.4-7.9) months (p = 0.495) and since the initial drainage 9.8 (95 %CI 6.9-12.7) vs 9.1 (95 %CI 5.4-12.7) months (p = 0.720) in the control and experimental arm. Conclusion: Endobiliary radiofrequency ablation prior metal stent insertion showed increased patency rate only in patients with cholangiocarcinoma, on the other hand, no improvement in survival was demonstrated in this randomized clinical study.
ER -
ANDRAŠINA, Tomáš, Tomáš ROHAN, Jiří PÁNEK, Petra KOVALČÍKOVÁ, Lumír KUNOVSKÝ, Lenka OSTŘÍŽKOVÁ and Vlastimil VÁLEK. The combination of endoluminal radiofrequency ablation and metal stent implantation for the treatment of malignant biliary stenosis-Randomized study. \textit{European journal of radiology}. Ireland: Elsevier Science Ireland Ltd, 2021, vol.~142, September 2021, p.~1-7. ISSN~0720-048X. Available from: https://dx.doi.org/10.1016/j.ejrad.2021.109830.
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