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@proceedings{1794523, author = {Havránková, Eva}, booktitle = {Conference Synthesis and Analysis of Drugs 2021}, language = {eng}, title = {Triazinyl-substituted benzenesulfonamides as inhibitors of bacterial carbonic anhydrase}, year = {2021} }
TY - CONF ID - 1794523 AU - Havránková, Eva PY - 2021 TI - Triazinyl-substituted benzenesulfonamides as inhibitors of bacterial carbonic anhydrase N2 - Carbonic anhydrases (CA, EC 4.2.1.1) are metalloenzymes present in pathogenic bacteria. CAs play an important role in growth and survival in bacteria. Inhibition of bacterial CAs leads to growth retardation, growth defects and makes bacterias vulnerable to host defense mechanisms. Bacterial CAs are therefore a very promising target in the search for new antibiotics. The new 1,3,5-triazinyl aminobenzenesulfonamide derivatives containing aminoalcohole, aminochalcone and other structural moieties were synthesized, and their biological activity was evaluated. Some of the tested compounds exhibit a significant inhibitory activity against vancomycin resistant Enterococcus faecalis, while against relevant human CAs they showed almost negligible inhibitory activity. In conclusion, newly prepared compounds have a great potential as antibacterial agents with high activity and at the same time with high selectivity for bacterial CA in comparison with metabolically important hCA isoenzymes (e.g. hCA I, hCA II) found in the human body. ER -
HAVRÁNKOVÁ, Eva. Triazinyl-substituted benzenesulfonamides as inhibitors of bacterial carbonic anhydrase. In \textit{Conference Synthesis and Analysis of Drugs 2021}. 2021.
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