Homeostatic model of human thermoregulation with bi-stability

J 2021

Homeostatic model of human thermoregulation with bi-stability

ECLEROVÁ, Veronika; Filip ZLÁMAL; Peter LENÁRT a Julie DOBROVOLNÁ

Základní údaje

Originální název

Homeostatic model of human thermoregulation with bi-stability

Autoři

ECLEROVÁ, Veronika; Filip ZLÁMAL ; Peter LENÁRT a Julie DOBROVOLNÁ

Vydání

Nature Scientific Reports, London, NATURE RESEARCH, 2021, 2045-2322

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10700 1.7 Other natural sciences

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.997

Kód RIV

RIV/00216224:14310/21:00122533

Organizační jednotka

Přírodovědecká fakulta

DOI

https://doi.org/10.1038/s41598-021-96280-0

UT WoS

000693354000043

EID Scopus

2-s2.0-85113899428

Klíčová slova anglicky

BIFURCATION-ANALYSIS; CATASTROPHE-THEORY; MATCONT

Štítky

14311010, 143180, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 8. 6. 2025 11:46, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

All homoiothermic organisms are capable of maintaining a stable body temperature using various negative feedback mechanisms. However, current models cannot satisfactorily describe the thermal adaptation of homoiothermic living systems in a physiologically meaningful way. Previously, we introduced stress entropic load, a novel variable designed to quantify adaptation costs, i.e. the stress of the organism, using a thermodynamic approach. In this study, we use stress entropic load as a starting point for the construction of a novel dynamical model of human thermoregulation. This model exhibits bi-stable mechanisms, a physiologically plausible features which has thus far not been demonstrated using a mathematical model. This finding allows us to predict critical points at which a living system, in this case a human body, may proceed towards two stabilities, only one of which is compatible with being alive. In the future, this may allow us to quantify not only the direction but rather the extent of therapeutic intervention in critical care patients.

Návaznosti

EF15_003/0000469, projekt VaV

Název: Cetocoen Plus

EF17_043/0009632, projekt VaV

Název: CETOCOEN Excellence

MUNI/A/1418/2019, interní kód MU

Název: Matematické a statistické modelování 4 (Akronym: MaStaMo4)

Investor: Masarykova univerzita, Matematické a statistické modelování 4, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

857560, interní kód MU
(Kód CEP: EF17_043/0009632)

Název: CETOCOEN Excellence (Akronym: CETOCOEN Excellence)

Investor: Evropská unie, CETOCOEN Excellence, Spreading excellence and widening participation

90121, velká výzkumná infrastruktura

Název: RECETOX RI

Přiložené soubory

1796197.pdf

Citovat

ECLEROVÁ, Veronika; Filip ZLÁMAL; Peter LENÁRT a Julie DOBROVOLNÁ. Homeostatic model of human thermoregulation with bi-stability. Nature Scientific Reports. London: NATURE RESEARCH, 2021, roč. 11, č. 1, s. 1-8. ISSN 2045-2322. Dostupné z: https://doi.org/10.1038/s41598-021-96280-0.

@article{1796197,
   author = {Eclerová, Veronika and Zlámal, Filip and Lenárt, Peter and Dobrovolná, Julie},
   article_location = {London},
   article_number = {1},
   doi = {https://doi.org/10.1038/s41598-021-96280-0},
   keywords = {BIFURCATION-ANALYSIS; CATASTROPHE-THEORY; MATCONT},
   language = {eng},
   issn = {2045-2322},
   journal = {Nature Scientific Reports},
   title = {Homeostatic model of human thermoregulation with bi-stability},
   url = {https://www.nature.com/articles/s41598-021-96280-0},
   volume = {11},
   year = {2021}
}

TY  - JOUR
ID  - 1796197
AU  - Eclerová, Veronika - Zlámal, Filip - Lenárt, Peter - Dobrovolná, Julie
PY  - 2021
TI  - Homeostatic model of human thermoregulation with bi-stability
JF  - Nature Scientific Reports
VL  - 11
IS  - 1
SP  - 1-8
EP  - 1-8
PB  - NATURE RESEARCH
SN  - 20452322
KW  - BIFURCATION-ANALYSIS
KW  - CATASTROPHE-THEORY
KW  - MATCONT
UR  - https://www.nature.com/articles/s41598-021-96280-0
N2  - All homoiothermic organisms are capable of maintaining a stable body temperature using various negative feedback mechanisms. However, current models cannot satisfactorily describe the thermal adaptation of homoiothermic living systems in a physiologically meaningful way. Previously, we introduced stress entropic load, a novel variable designed to quantify adaptation costs, i.e. the stress of the organism, using a thermodynamic approach. In this study, we use stress entropic load as a starting point for the construction of a novel dynamical model of human thermoregulation. This model exhibits bi-stable mechanisms, a physiologically plausible features which has thus far not been demonstrated using a mathematical model. This finding allows us to predict critical points at which a living system, in this case a human body, may proceed towards two stabilities, only one of which is compatible with being alive. In the future, this may allow us to quantify not only the direction but rather the extent of therapeutic intervention in critical care patients.
ER  -

ECLEROVÁ, Veronika; Filip ZLÁMAL; Peter LENÁRT a Julie DOBROVOLNÁ. Homeostatic model of human thermoregulation with bi-stability. \textit{Nature Scientific Reports}. London: NATURE RESEARCH, 2021, roč.~11, č.~1, s.~1-8. ISSN~2045-2322. Dostupné z: https://doi.org/10.1038/s41598-021-96280-0.

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