Homeostatic model of human thermoregulation with bi-stability

J 2021

Homeostatic model of human thermoregulation with bi-stability

ECLEROVÁ, Veronika, Filip ZLÁMAL, Peter LENÁRT and Julie DOBROVOLNÁ

Basic information

Original name

Homeostatic model of human thermoregulation with bi-stability

Authors

ECLEROVÁ, Veronika (203 Czech Republic, belonging to the institution), Filip ZLÁMAL (203 Czech Republic, belonging to the institution), Peter LENÁRT (703 Slovakia, belonging to the institution) and Julie DOBROVOLNÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Nature Scientific Reports, London, NATURE RESEARCH, 2021, 2045-2322

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10700 1.7 Other natural sciences

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.996

RIV identification code

RIV/00216224:14310/21:00122533

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1038/s41598-021-96280-0

UT WoS

000693354000043

Keywords in English

BIFURCATION-ANALYSIS; CATASTROPHE-THEORY; MATCONT

Abstract

V originále

All homoiothermic organisms are capable of maintaining a stable body temperature using various negative feedback mechanisms. However, current models cannot satisfactorily describe the thermal adaptation of homoiothermic living systems in a physiologically meaningful way. Previously, we introduced stress entropic load, a novel variable designed to quantify adaptation costs, i.e. the stress of the organism, using a thermodynamic approach. In this study, we use stress entropic load as a starting point for the construction of a novel dynamical model of human thermoregulation. This model exhibits bi-stable mechanisms, a physiologically plausible features which has thus far not been demonstrated using a mathematical model. This finding allows us to predict critical points at which a living system, in this case a human body, may proceed towards two stabilities, only one of which is compatible with being alive. In the future, this may allow us to quantify not only the direction but rather the extent of therapeutic intervention in critical care patients.

Links

EF15_003/0000469, research and development project

Name: Cetocoen Plus

EF17_043/0009632, research and development project

Name: CETOCOEN Excellence

LM2018121, research and development project

Name: Výzkumná infrastruktura RECETOX (Acronym: RECETOX RI)

Investor: Ministry of Education, Youth and Sports of the CR, RECETOX RI

MUNI/A/1418/2019, interní kód MU

Name: Matematické a statistické modelování 4 (Acronym: MaStaMo4)

Investor: Masaryk University, Category A

857560, interní kód MU
(CEP code: EF17_043/0009632)

Name: CETOCOEN Excellence (Acronym: CETOCOEN Excellence)

Investor: European Union, Spreading excellence and widening participation

Files attached

1796197.pdf

Find similar documents

Citovat

ECLEROVÁ, Veronika, Filip ZLÁMAL, Peter LENÁRT and Julie DOBROVOLNÁ. Homeostatic model of human thermoregulation with bi-stability. Nature Scientific Reports. London: NATURE RESEARCH, 2021, vol. 11, No 1, p. 1-8. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/s41598-021-96280-0.

@article{1796197,
   author = {Eclerová, Veronika and Zlámal, Filip and Lenárt, Peter and Dobrovolná, Julie},
   article_location = {London},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s41598-021-96280-0},
   keywords = {BIFURCATION-ANALYSIS; CATASTROPHE-THEORY; MATCONT},
   language = {eng},
   issn = {2045-2322},
   journal = {Nature Scientific Reports},
   title = {Homeostatic model of human thermoregulation with bi-stability},
   url = {https://www.nature.com/articles/s41598-021-96280-0},
   volume = {11},
   year = {2021}
}

TY  - JOUR
ID  - 1796197
AU  - Eclerová, Veronika - Zlámal, Filip - Lenárt, Peter - Dobrovolná, Julie
PY  - 2021
TI  - Homeostatic model of human thermoregulation with bi-stability
JF  - Nature Scientific Reports
VL  - 11
IS  - 1
SP  - 1-8
EP  - 1-8
PB  - NATURE RESEARCH
SN  - 20452322
KW  - BIFURCATION-ANALYSIS
KW  - CATASTROPHE-THEORY
KW  - MATCONT
UR  - https://www.nature.com/articles/s41598-021-96280-0
N2  - All homoiothermic organisms are capable of maintaining a stable body temperature using various negative feedback mechanisms. However, current models cannot satisfactorily describe the thermal adaptation of homoiothermic living systems in a physiologically meaningful way. Previously, we introduced stress entropic load, a novel variable designed to quantify adaptation costs, i.e. the stress of the organism, using a thermodynamic approach. In this study, we use stress entropic load as a starting point for the construction of a novel dynamical model of human thermoregulation. This model exhibits bi-stable mechanisms, a physiologically plausible features which has thus far not been demonstrated using a mathematical model. This finding allows us to predict critical points at which a living system, in this case a human body, may proceed towards two stabilities, only one of which is compatible with being alive. In the future, this may allow us to quantify not only the direction but rather the extent of therapeutic intervention in critical care patients.
ER  -

ECLEROVÁ, Veronika, Filip ZLÁMAL, Peter LENÁRT and Julie DOBROVOLNÁ. Homeostatic model of human thermoregulation with bi-stability. \textit{Nature Scientific Reports}. London: NATURE RESEARCH, 2021, vol.~11, No~1, p.~1-8. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-021-96280-0.

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