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@article{1796197,
author = {Eclerová, Veronika and Zlámal, Filip and Lenárt, Peter and Dobrovolná, Julie},
article_location = {London},
article_number = {1},
doi = {http://dx.doi.org/10.1038/s41598-021-96280-0},
keywords = {BIFURCATION-ANALYSIS; CATASTROPHE-THEORY; MATCONT},
language = {eng},
issn = {2045-2322},
journal = {Nature Scientific Reports},
title = {Homeostatic model of human thermoregulation with bi-stability},
url = {https://www.nature.com/articles/s41598-021-96280-0},
volume = {11},
year = {2021}
}
TY - JOUR
ID - 1796197
AU - Eclerová, Veronika - Zlámal, Filip - Lenárt, Peter - Dobrovolná, Julie
PY - 2021
TI - Homeostatic model of human thermoregulation with bi-stability
JF - Nature Scientific Reports
VL - 11
IS - 1
SP - 1-8
EP - 1-8
PB - NATURE RESEARCH
SN - 20452322
KW - BIFURCATION-ANALYSIS
KW - CATASTROPHE-THEORY
KW - MATCONT
UR - https://www.nature.com/articles/s41598-021-96280-0
N2 - All homoiothermic organisms are capable of maintaining a stable body temperature using various negative feedback mechanisms. However, current models cannot satisfactorily describe the thermal adaptation of homoiothermic living systems in a physiologically meaningful way. Previously, we introduced stress entropic load, a novel variable designed to quantify adaptation costs, i.e. the stress of the organism, using a thermodynamic approach. In this study, we use stress entropic load as a starting point for the construction of a novel dynamical model of human thermoregulation. This model exhibits bi-stable mechanisms, a physiologically plausible features which has thus far not been demonstrated using a mathematical model. This finding allows us to predict critical points at which a living system, in this case a human body, may proceed towards two stabilities, only one of which is compatible with being alive. In the future, this may allow us to quantify not only the direction but rather the extent of therapeutic intervention in critical care patients.
ER -
ECLEROVÁ, Veronika, Filip ZLÁMAL, Peter LENÁRT and Julie DOBROVOLNÁ. Homeostatic model of human thermoregulation with bi-stability. \textit{Nature Scientific Reports}. London: NATURE RESEARCH, 2021, vol.~11, No~1, p.~1-8. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-021-96280-0.
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