Detailed Information on Publication Record
2021
Stereocontrolled Synthesis of Pseurotin A(2)
JACHAK, Gorakhnath Rajaram, Prabhakara Rao THARRA, Petr SEVELDA and Jakub ŠVENDABasic information
Original name
Stereocontrolled Synthesis of Pseurotin A(2)
Authors
JACHAK, Gorakhnath Rajaram (356 India, belonging to the institution), Prabhakara Rao THARRA (356 India, belonging to the institution), Petr SEVELDA (203 Czech Republic, belonging to the institution) and Jakub ŠVENDA (203 Czech Republic, guarantor, belonging to the institution)
Edition
Journal of Organic Chemistry, Washington, D.C. American Chemical Society, 2021, 0022-3263
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10401 Organic chemistry
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 4.198
RIV identification code
RIV/00216224:14310/21:00122547
Organization unit
Faculty of Science
UT WoS
000693628600047
Keywords in English
Mixtures; Organic compounds; Anions; Solutions; Ethyl groups
Tags
Tags
International impact, Reviewed
Změněno: 22/1/2024 11:08, Mgr. Pavla Foltynová, Ph.D.
Abstract
V originále
We report synthesis of two diastereomeric structures previously proposed for the complex secondary metabolite pseurotin A(2). Both structures were accessed from the same building blocks taking advantage of a stereodivergent nickel(II)-iamine-catalyzed 1,4-addition of a chiral 2-alkoxycarbonyl-3(2H)-furanone. Late-stage Csp-Csp(3) cross-coupling of a highly functionalized bromoalkyne featured in the pseurotin A(2) side-chain assembly. The work supports the 2016 stereochemical revision of pseurotin A(2) and represents the first chemical synthesis of this natural product.
Links
| EF16_025/0007381, research and development project |
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| EF16_027/0008360, research and development project |
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| LM2015063, research and development project |
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