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@proceedings{1797077,
author = {Souralová, Tereza and Holubcová, Zuzana and Kyjovská, Drahomíra and Hampl, Aleš and Koutná, Irena},
booktitle = {XII. international conference „Bioimplantologie 2021“, Mikulov, Czech Republic},
keywords = {clinical-grade human embryonic stem cells; derivation and characterization},
language = {eng},
isbn = {978-80-01-06886-1},
title = {Derivation and characterization of clinical-grade human embryonic stem cells},
year = {2021}
}
TY - CONF
ID - 1797077
AU - Souralová, Tereza - Holubcová, Zuzana - Kyjovská, Drahomíra - Hampl, Aleš - Koutná, Irena
PY - 2021
TI - Derivation and characterization of clinical-grade human embryonic stem cells
SN - 9788001068861
KW - clinical-grade human embryonic stem cells
KW - derivation and characterization
N2 - Human embryonic stem cells (hESCs) represent an unlimited source of cells for the differentiation into the derivates that are suitable for a variety of biomedical applications. Cell therapies, disease modeling, and drug testing, which are examples of application, demand robust and replicable protocols for the derivation and differentiation of hESCs. Nevertheless, allogeneic background and undefined culture conditions are limitations of current protocols. Therefore, here we present the generation of the two sex-discordant sibling hESC lines, MUNIe008-A and MUNIe009-A, using the mechanical biopsy of vitrified-thawed embryos (excess for fertility treatment) under xeno- and feeder-free conditions. The presented approach is applicable for deriving high-quality clinicalgrade hESC lines for a variety of clinical applications.
ER -
SOURALOVÁ, Tereza, Zuzana HOLUBCOVÁ, Drahomíra KYJOVSKÁ, Aleš HAMPL and Irena KOUTNÁ. Derivation and characterization of clinical-grade human embryonic stem cells. In \textit{XII. international conference „Bioimplantologie 2021“, Mikulov, Czech Republic}. 2021. ISBN~978-80-01-06886-1.
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