| KODAMA, Joe, Anjar Anggraini HARUMNINGTYAS, Tomoko ITO, Miroslav MICHLÍČEK, Satoshi SUGIMOTO, Hidekazu KITA, Ryota CHIJIMATSU, Yuichiro UKON, Junichi KUSHIOKA, Rintaro OKADA, Takashi KAMATANI, Kunihiko HASHIMOTO, Daisuke TATEIWA, Hiroyuki TSUKAZAKI, Shinichi NAKAGAWA, Shota TAKENAKA, Takahiro MAKINO, Yusuke SAKAI, David NEČAS, Lenka ZAJÍČKOVÁ, Satoshi HAMAGUCHI and Takashi KAITO. Amine modification of calcium phosphate by low-pressure plasma for bone regeneration. Scientific Reports. London: Nature Research, 2021, vol. 11, No 1, p. "17870", 15 pp. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/s41598-021-97460-8. |
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@article{1797670,
author = {Kodama, Joe and Harumningtyas, Anjar Anggraini and Ito, Tomoko and Michlíček, Miroslav and Sugimoto, Satoshi and Kita, Hidekazu and Chijimatsu, Ryota and Ukon, Yuichiro and Kushioka, Junichi and Okada, Rintaro and Kamatani, Takashi and Hashimoto, Kunihiko and Tateiwa, Daisuke and Tsukazaki, Hiroyuki and Nakagawa, Shinichi and Takenaka, Shota and Makino, Takahiro and Sakai, Yusuke and Nečas, David and Zajíčková, Lenka and Hamaguchi, Satoshi and Kaito, Takashi},
article_location = {London},
article_number = {1},
doi = {http://dx.doi.org/10.1038/s41598-021-97460-8},
keywords = {mesenchymal stem cell; osteoblast differentiation; integrins bind; in-vitro; adhesion; fibronectin; polymerization},
language = {eng},
issn = {2045-2322},
journal = {Scientific Reports},
title = {Amine modification of calcium phosphate by low-pressure plasma for bone regeneration},
url = {https://doi.org/10.1038/s41598-021-97460-8},
volume = {11},
year = {2021}
}
TY - JOUR
ID - 1797670
AU - Kodama, Joe - Harumningtyas, Anjar Anggraini - Ito, Tomoko - Michlíček, Miroslav - Sugimoto, Satoshi - Kita, Hidekazu - Chijimatsu, Ryota - Ukon, Yuichiro - Kushioka, Junichi - Okada, Rintaro - Kamatani, Takashi - Hashimoto, Kunihiko - Tateiwa, Daisuke - Tsukazaki, Hiroyuki - Nakagawa, Shinichi - Takenaka, Shota - Makino, Takahiro - Sakai, Yusuke - Nečas, David - Zajíčková, Lenka - Hamaguchi, Satoshi - Kaito, Takashi
PY - 2021
TI - Amine modification of calcium phosphate by low-pressure plasma for bone regeneration
JF - Scientific Reports
VL - 11
IS - 1
SP - "17870"
EP - "17870"
PB - Nature Research
SN - 20452322
KW - mesenchymal stem cell
KW - osteoblast differentiation
KW - integrins bind
KW - in-vitro
KW - adhesion
KW - fibronectin
KW - polymerization
UR - https://doi.org/10.1038/s41598-021-97460-8
N2 - Regeneration of large bone defects caused by trauma or tumor resection remains one of the biggest challenges in orthopedic surgery. Because of the limited availability of autograft material, the use of artificial bone is prevalent; however, the primary role of currently available artificial bone is restricted to acting as a bone graft extender owing to the lack of osteogenic ability. To explore whether surface modification might enhance artificial bone functionality, in this study we applied low-pressure plasma technology as next-generation surface treatment and processing strategy to chemically (amine) modify the surface of beta-tricalcium phosphate (beta-TCP) artificial bone using a CH4/N-2/He gas mixture. Plasma-treated beta-TCP exhibited significantly enhanced hydrophilicity, facilitating the deep infiltration of cells into interconnected porous beta-TCP. Additionally, cell adhesion and osteogenic differentiation on the plasma-treated artificial bone surfaces were also enhanced. Furthermore, in a rat calvarial defect model, the plasma treatment afforded high bone regeneration capacity. Together, these results suggest that amine modification of artificial bone by plasma technology can provide a high osteogenic ability and represents a promising strategy for resolving current clinical limitations regarding the use of artificial bone.
ER -
KODAMA, Joe, Anjar Anggraini HARUMNINGTYAS, Tomoko ITO, Miroslav MICHLÍČEK, Satoshi SUGIMOTO, Hidekazu KITA, Ryota CHIJIMATSU, Yuichiro UKON, Junichi KUSHIOKA, Rintaro OKADA, Takashi KAMATANI, Kunihiko HASHIMOTO, Daisuke TATEIWA, Hiroyuki TSUKAZAKI, Shinichi NAKAGAWA, Shota TAKENAKA, Takahiro MAKINO, Yusuke SAKAI, David NEČAS, Lenka ZAJÍČKOVÁ, Satoshi HAMAGUCHI and Takashi KAITO. Amine modification of calcium phosphate by low-pressure plasma for bone regeneration. \textit{Scientific Reports}. London: Nature Research, 2021, vol.~11, No~1, p.~''17870'', 15 pp. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-021-97460-8.
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