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@article{1798681, author = {Aswad, Mohamed Hussam and Kissová, Jarmila and Ovesná, Petra and Penka, Miroslav}, article_location = {Bratislava}, article_number = {6}, doi = {http://dx.doi.org/10.4149/neo_2021_210729N1068}, keywords = {Myeloproliferative neoplasm; Thrombosis; Risk factor; JAK2V617F mutation; Smoking}, language = {eng}, issn = {0028-2685}, journal = {Neoplasma}, title = {Risk factors of thrombosis in a cohort of 206 patients with BCR-ABL1 negative myeloproliferative neoplasms}, url = {http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=7426&category_id=172&option=com_virtuemart&vmcchk=1&Itemid=1}, volume = {68}, year = {2021} }
TY - JOUR ID - 1798681 AU - Aswad, Mohamed Hussam - Kissová, Jarmila - Ovesná, Petra - Penka, Miroslav PY - 2021 TI - Risk factors of thrombosis in a cohort of 206 patients with BCR-ABL1 negative myeloproliferative neoplasms JF - Neoplasma VL - 68 IS - 6 SP - 1341-1350 EP - 1341-1350 PB - Slovenská akademie vied SN - 00282685 KW - Myeloproliferative neoplasm KW - Thrombosis KW - Risk factor KW - JAK2V617F mutation KW - Smoking UR - http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=7426&category_id=172&option=com_virtuemart&vmcchk=1&Itemid=1 N2 - Thrombosis is the most common complication in BCR-ABL1 negative myeloproliferative neoplasms (MPN) that significantly impacts patients’ mortality. Generally, there is an agreement on risk factors that possibly contribute to the increased risk of thrombosis, including age, history of thrombosis, JAK2V617F mutation, and cardiovascular risk factors. This study retrospectively investigates MPN-related and patient-related variables in relation to the thrombosis occurrence in MPN. Our analyses show that JAK2V617F-mutated patients are at a significantly increased risk of thrombosis within five years before the MPN diagnosis point with a hazard ratio (HR) of 15.49 (P = 0.006). In multivariate analyses, independent risk factors for thrombotic complications during the follow-up are history of thrombosis (HR = 2.23, P = 0.019), age over 60 years at diagnosis (HR = 1.56, P = 0.037), the presence of JAK2V617F mutation (HR = 3.01, P = 0.002), and tobacco smoking (HR = 1.75, P = 0.01). Our results support the multifactorial mechanism of thrombosis in MPN patients, which demands individual and complex management. ER -
ASWAD, Mohamed Hussam, Jarmila KISSOVÁ, Petra OVESNÁ and Miroslav PENKA. Risk factors of thrombosis in a cohort of 206 patients with BCR-ABL1 negative myeloproliferative neoplasms. \textit{Neoplasma}. Bratislava: Slovenská akademie vied, 2021, vol.~68, No~6, p.~1341-1350. ISSN~0028-2685. Available from: https://dx.doi.org/10.4149/neo\_{}2021\_{}210729N1068.
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