Risk factors of thrombosis in a cohort of 206 patients with
BCR-ABL1 negative myeloproliferative neoplasms

J 2021

Risk factors of thrombosis in a cohort of 206 patients with BCR-ABL1 negative myeloproliferative neoplasms

ASWAD, Mohamed Hussam, Jarmila KISSOVÁ, Petra OVESNÁ and Miroslav PENKA

Basic information

Original name

Risk factors of thrombosis in a cohort of 206 patients with BCR-ABL1 negative myeloproliferative neoplasms

Authors

ASWAD, Mohamed Hussam (760 Syrian Arab Republic, guarantor, belonging to the institution), Jarmila KISSOVÁ (203 Czech Republic, belonging to the institution), Petra OVESNÁ (203 Czech Republic, belonging to the institution) and Miroslav PENKA (203 Czech Republic, belonging to the institution)

Edition

Neoplasma, Bratislava, Slovenská akademie vied, 2021, 0028-2685

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30205 Hematology

Country of publisher

Slovakia

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.409

RIV identification code

RIV/00216224:14110/21:00122606

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.4149/neo_2021_210729N1068

UT WoS

000729198300012

Keywords in English

Myeloproliferative neoplasm; Thrombosis; Risk factor; JAK2V617F mutation; Smoking

Abstract

V originále

Thrombosis is the most common complication in BCR-ABL1 negative myeloproliferative neoplasms (MPN) that significantly impacts patients’ mortality. Generally, there is an agreement on risk factors that possibly contribute to the increased risk of thrombosis, including age, history of thrombosis, JAK2V617F mutation, and cardiovascular risk factors. This study retrospectively investigates MPN-related and patient-related variables in relation to the thrombosis occurrence in MPN. Our analyses show that JAK2V617F-mutated patients are at a significantly increased risk of thrombosis within five years before the MPN diagnosis point with a hazard ratio (HR) of 15.49 (P = 0.006). In multivariate analyses, independent risk factors for thrombotic complications during the follow-up are history of thrombosis (HR = 2.23, P = 0.019), age over 60 years at diagnosis (HR = 1.56, P = 0.037), the presence of JAK2V617F mutation (HR = 3.01, P = 0.002), and tobacco smoking (HR = 1.75, P = 0.01). Our results support the multifactorial mechanism of thrombosis in MPN patients, which demands individual and complex management.

Citovat

ASWAD, Mohamed Hussam, Jarmila KISSOVÁ, Petra OVESNÁ and Miroslav PENKA. Risk factors of thrombosis in a cohort of 206 patients with BCR-ABL1 negative myeloproliferative neoplasms. Neoplasma. Bratislava: Slovenská akademie vied, 2021, vol. 68, No 6, p. 1341-1350. ISSN 0028-2685. Available from: https://dx.doi.org/10.4149/neo_2021_210729N1068.

@article{1798681,
   author = {Aswad, Mohamed Hussam and Kissová, Jarmila and Ovesná, Petra and Penka, Miroslav},
   article_location = {Bratislava},
   article_number = {6},
   doi = {http://dx.doi.org/10.4149/neo_2021_210729N1068},
   keywords = {Myeloproliferative neoplasm; Thrombosis; Risk factor; JAK2V617F mutation; Smoking},
   language = {eng},
   issn = {0028-2685},
   journal = {Neoplasma},
   title = {Risk factors of thrombosis in a cohort of 206 patients with BCR-ABL1 negative myeloproliferative neoplasms},
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   volume = {68},
   year = {2021}
}

TY  - JOUR
ID  - 1798681
AU  - Aswad, Mohamed Hussam - Kissová, Jarmila - Ovesná, Petra - Penka, Miroslav
PY  - 2021
TI  - Risk factors of thrombosis in a cohort of 206 patients with BCR-ABL1 negative myeloproliferative neoplasms
JF  - Neoplasma
VL  - 68
IS  - 6
SP  - 1341-1350
EP  - 1341-1350
PB  - Slovenská akademie vied
SN  - 00282685
KW  - Myeloproliferative neoplasm
KW  - Thrombosis
KW  - Risk factor
KW  - JAK2V617F mutation
KW  - Smoking
UR  - http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=7426&category_id=172&option=com_virtuemart&vmcchk=1&Itemid=1
N2  - Thrombosis is the most common complication in BCR-ABL1 negative myeloproliferative neoplasms (MPN) that significantly impacts patients’ mortality. Generally, there is an agreement on risk factors that possibly contribute to the increased risk of thrombosis, including age, history of thrombosis, JAK2V617F mutation, and cardiovascular risk factors. This study retrospectively investigates MPN-related and patient-related variables in relation to the thrombosis occurrence in MPN. Our analyses show that JAK2V617F-mutated patients are at a significantly increased risk of thrombosis within five years before the MPN diagnosis point with a hazard ratio (HR) of 15.49 (P = 0.006). In multivariate analyses, independent risk factors for thrombotic complications during the follow-up are history of thrombosis (HR = 2.23, P = 0.019), age over 60 years at diagnosis (HR = 1.56, P = 0.037), the presence of JAK2V617F mutation (HR = 3.01, P = 0.002), and tobacco smoking (HR = 1.75, P = 0.01). Our results support the multifactorial mechanism of thrombosis in MPN patients, which demands individual and complex management.
ER  -

ASWAD, Mohamed Hussam, Jarmila KISSOVÁ, Petra OVESNÁ and Miroslav PENKA. Risk factors of thrombosis in a cohort of 206 patients with BCR-ABL1 negative myeloproliferative neoplasms. \textit{Neoplasma}. Bratislava: Slovenská akademie vied, 2021, vol.~68, No~6, p.~1341-1350. ISSN~0028-2685. Available from: https://dx.doi.org/10.4149/neo\_{}2021\_{}210729N1068.

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