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@article{1798682, author = {Aswad, Mohamed Hussam and Kissová, Jarmila and Ovesná, Petra and Říhová, Lucie and Penka, Miroslav}, article_location = {Athens}, article_number = {6}, doi = {http://dx.doi.org/10.21873/invivo.12632}, keywords = {Myeloproliferative neoplasm; microparticle; procoagulant activity; thrombosis; anagrelide; hydroxyurea}, language = {eng}, issn = {0258-851X}, journal = {In vivo}, title = {The clinical significance of circulating microparticles concerning thrombosis in BCR/ABL1-negative myeloproliferative neoplasms}, url = {https://iv.iiarjournals.org/content/35/6/3345}, volume = {35}, year = {2021} }
TY - JOUR ID - 1798682 AU - Aswad, Mohamed Hussam - Kissová, Jarmila - Ovesná, Petra - Říhová, Lucie - Penka, Miroslav PY - 2021 TI - The clinical significance of circulating microparticles concerning thrombosis in BCR/ABL1-negative myeloproliferative neoplasms JF - In vivo VL - 35 IS - 6 SP - 3345-3353 EP - 3345-3353 PB - International Institute of Anticancer Research SN - 0258851X KW - Myeloproliferative neoplasm KW - microparticle KW - procoagulant activity KW - thrombosis KW - anagrelide KW - hydroxyurea UR - https://iv.iiarjournals.org/content/35/6/3345 N2 - Background/Aim: This work aimed to prospectively evaluate the clinical significance of circulating microparticles (MPs) in relation to thrombotic risk factors and thrombotic complications in patients with BCR/ABL1-negative myeloproliferative neoplasms (MPN). Patients and Methods: In a cohort of 206 patients with MPN, MPs’ procoagulant activity was measured by the Zymuphen functional assay in 429 samples, while platelet- and erythrocyte-MPs were enumerated by flow cytometry in 558 samples. Results: MPN patients had higher MP levels than the control group. The levels of MPs were higher in male patients, smokers, and those who were older than 60 years, and in the presence of JAK2V617F mutation, history of thrombosis, platelets >400×109/l, hematocrit >45%, or leukocytes >10×109/l. Cytoreductive treatment reduced MP levels, with anagrelide being associated with lower MP levels than hydroxyurea. Conclusion: The relationship with thrombotic risk factors indicates a possible role of MPs in the complex thrombotic mechanism, though cytoreductive treatment seems to affect this role through reducing MP levels. ER -
ASWAD, Mohamed Hussam, Jarmila KISSOVÁ, Petra OVESNÁ, Lucie ŘÍHOVÁ and Miroslav PENKA. The clinical significance of circulating microparticles concerning thrombosis in BCR/ABL1-negative myeloproliferative neoplasms. \textit{In vivo}. Athens: International Institute of Anticancer Research, 2021, vol.~35, No~6, p.~3345-3353. ISSN~0258-851X. Available from: https://dx.doi.org/10.21873/invivo.12632.
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