Diagnostic contribution and therapeutic perspectives of
transcranial magnetic stimulation in dementia

J 2021

Diagnostic contribution and therapeutic perspectives of transcranial magnetic stimulation in dementia

DI LAZZARO, Vincenzo, Rita BELLA, Alberto BENUSSI, Matteo BOLOGNA, Barbara BORRONI et. al.

Basic information

Original name

Diagnostic contribution and therapeutic perspectives of transcranial magnetic stimulation in dementia

Authors

DI LAZZARO, Vincenzo (guarantor), Rita BELLA, Alberto BENUSSI, Matteo BOLOGNA, Barbara BORRONI, Fioravante CAPONE, Kai-Hsiang S. CHEN, Robert CHEN, Andrei CHISTYAKOV, Joseph CLASSEN, Matthew C. KIERNAN, Giacomo KOCH, Giuseppe LANZA, Jean-Pascal LEFAUCHEUR, Hideyuki MATSUMOTO, Jean-Paul NGUYEN, Michael ORTH, Alvaro PASCUAL-LEONE, Irena REKTOROVÁ (203 Czech Republic, belonging to the institution), Patrik ŠIMKO (703 Slovakia, belonging to the institution), John-Paul TAYLOR, Sara TREMBLAY, Yoshikazu UGAWA, Raffaele DUBBIOSO and Federico RANIERI

Edition

Clinical Neurophysiology, Clare, Elsevier Ireland, 2021, 1388-2457

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.861

RIV identification code

RIV/00216224:14110/21:00120154

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.clinph.2021.05.035

UT WoS

000704914800030

Keywords in English

Brain stimulationCortical excitabilityPlasticityBiomarkerConnectivityPrecision medicine

Abstract

V originále

Transcranial magnetic stimulation (TMS) is a powerful tool to probe in vivo brain circuits, as it allows to assess several cortical properties such as excitability, plasticity and connectivity in humans. In the last 20 years, TMS has been applied to patients with dementia, enabling the identification of potential markers of the pathophysiology and predictors of cognitive decline; moreover, applied repetitively, TMS holds promise as a potential therapeutic intervention. The objective of this paper is to present a comprehensive review of studies that have employed TMS in dementia and to discuss potential clinical applications, from the diagnosis to the treatment. To provide a technical and theoretical framework, we first present an overview of the basic physiological mechanisms of the application of TMS to assess cortical excitability, excitation and inhibition balance, mechanisms of plasticity and cortico-cortical connectivity in the human brain. We then review the insights gained by TMS techniques into the pathophysiology and predictors of progression and response to treatment in dementias, including Alzheimer's disease (AD)-related dementias and secondary dementias. We show that while a single TMS measure offers low specificity, the use of a panel of measures and/or neurophysiological index can support the clinical diagnosis and predict progression. In the last part of the article, we discuss the therapeutic uses of TMS. So far, only repetitive TMS (rTMS) over the left dorsolateral prefrontal cortex and multisite rTMS associated with cognitive training have been shown to be, respectively, possibly (Level C of evidence) and probably (Level B of evidence) effective to improve cognition, apathy, memory, and language in AD patients, especially at a mild/early stage of the disease. The clinical use of this type of treatment warrants the combination of brain imaging techniques and/or electrophysiological tools to elucidate neurobiological effects of neurostimulation and to optimally tailor rTMS treatment protocols in individual patients or specific patient subgroups with dementia or mild cognitive impairment. (c) 2021 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

Links

NV18-04-00256, research and development project

Name: Efekt transkraniální stimulace tDCS na zrakovou pozornost u pacientů s mírnou kognitivní poruchou - studie kombinující MRI a neinvazivní mozkovou stimulaci

Investor: Ministry of Health of the CR

Citovat

DI LAZZARO, Vincenzo, Rita BELLA, Alberto BENUSSI, Matteo BOLOGNA, Barbara BORRONI, Fioravante CAPONE, Kai-Hsiang S. CHEN, Robert CHEN, Andrei CHISTYAKOV, Joseph CLASSEN, Matthew C. KIERNAN, Giacomo KOCH, Giuseppe LANZA, Jean-Pascal LEFAUCHEUR, Hideyuki MATSUMOTO, Jean-Paul NGUYEN, Michael ORTH, Alvaro PASCUAL-LEONE, Irena REKTOROVÁ, Patrik ŠIMKO, John-Paul TAYLOR, Sara TREMBLAY, Yoshikazu UGAWA, Raffaele DUBBIOSO and Federico RANIERI. Diagnostic contribution and therapeutic perspectives of transcranial magnetic stimulation in dementia. Clinical Neurophysiology. Clare: Elsevier Ireland, 2021, vol. 132, No 10, p. 2568-2607. ISSN 1388-2457. Available from: https://dx.doi.org/10.1016/j.clinph.2021.05.035.

@article{1799847,
   author = {Di Lazzaro, Vincenzo and Bella, Rita and Benussi, Alberto and Bologna, Matteo and Borroni, Barbara and Capone, Fioravante and Chen, KaiandHsiang S. and Chen, Robert and Chistyakov, Andrei and Classen, Joseph and Kiernan, Matthew C. and Koch, Giacomo and Lanza, Giuseppe and Lefaucheur, JeanandPascal and Matsumoto, Hideyuki and Nguyen, JeanandPaul and Orth, Michael and PascualandLeone, Alvaro and Rektorová, Irena and Šimko, Patrik and Taylor, JohnandPaul and Tremblay, Sara and Ugawa, Yoshikazu and Dubbioso, Raffaele and Ranieri, Federico},
   article_location = {Clare},
   article_number = {10},
   doi = {http://dx.doi.org/10.1016/j.clinph.2021.05.035},
   keywords = {Brain stimulationCortical excitabilityPlasticityBiomarkerConnectivityPrecision medicine},
   language = {eng},
   issn = {1388-2457},
   journal = {Clinical Neurophysiology},
   title = {Diagnostic contribution and therapeutic perspectives of transcranial magnetic stimulation in dementia},
   url = {https://www.sciencedirect.com/science/article/pii/S1388245721006507?via%3Dihub},
   volume = {132},
   year = {2021}
}

TY  - JOUR
ID  - 1799847
AU  - Di Lazzaro, Vincenzo - Bella, Rita - Benussi, Alberto - Bologna, Matteo - Borroni, Barbara - Capone, Fioravante - Chen, Kai-Hsiang S. - Chen, Robert - Chistyakov, Andrei - Classen, Joseph - Kiernan, Matthew C. - Koch, Giacomo - Lanza, Giuseppe - Lefaucheur, Jean-Pascal - Matsumoto, Hideyuki - Nguyen, Jean-Paul - Orth, Michael - Pascual-Leone, Alvaro - Rektorová, Irena - Šimko, Patrik - Taylor, John-Paul - Tremblay, Sara - Ugawa, Yoshikazu - Dubbioso, Raffaele - Ranieri, Federico
PY  - 2021
TI  - Diagnostic contribution and therapeutic perspectives of transcranial magnetic stimulation in dementia
JF  - Clinical Neurophysiology
VL  - 132
IS  - 10
SP  - 2568-2607
EP  - 2568-2607
PB  - Elsevier Ireland
SN  - 13882457
KW  - Brain stimulationCortical excitabilityPlasticityBiomarkerConnectivityPrecision medicine
UR  - https://www.sciencedirect.com/science/article/pii/S1388245721006507?via%3Dihub
N2  - Transcranial magnetic stimulation (TMS) is a powerful tool to probe in vivo brain circuits, as it allows to assess several cortical properties such as excitability, plasticity and connectivity in humans. In the last 20 years, TMS has been applied to patients with dementia, enabling the identification of potential markers of the pathophysiology and predictors of cognitive decline; moreover, applied repetitively, TMS holds promise as a potential therapeutic intervention. The objective of this paper is to present a comprehensive review of studies that have employed TMS in dementia and to discuss potential clinical applications, from the diagnosis to the treatment. To provide a technical and theoretical framework, we first present an overview of the basic physiological mechanisms of the application of TMS to assess cortical excitability, excitation and inhibition balance, mechanisms of plasticity and cortico-cortical connectivity in the human brain. We then review the insights gained by TMS techniques into the pathophysiology and predictors of progression and response to treatment in dementias, including Alzheimer's disease (AD)-related dementias and secondary dementias. We show that while a single TMS measure offers low specificity, the use of a panel of measures and/or neurophysiological index can support the clinical diagnosis and predict progression. In the last part of the article, we discuss the therapeutic uses of TMS. So far, only repetitive TMS (rTMS) over the left dorsolateral prefrontal cortex and multisite rTMS associated with cognitive training have been shown to be, respectively, possibly (Level C of evidence) and probably (Level B of evidence) effective to improve cognition, apathy, memory, and language in AD patients, especially at a mild/early stage of the disease. The clinical use of this type of treatment warrants the combination of brain imaging techniques and/or electrophysiological tools to elucidate neurobiological effects of neurostimulation and to optimally tailor rTMS treatment protocols in individual patients or specific patient subgroups with dementia or mild cognitive impairment. (c) 2021 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.
ER  -

DI LAZZARO, Vincenzo, Rita BELLA, Alberto BENUSSI, Matteo BOLOGNA, Barbara BORRONI, Fioravante CAPONE, Kai-Hsiang S. CHEN, Robert CHEN, Andrei CHISTYAKOV, Joseph CLASSEN, Matthew C. KIERNAN, Giacomo KOCH, Giuseppe LANZA, Jean-Pascal LEFAUCHEUR, Hideyuki MATSUMOTO, Jean-Paul NGUYEN, Michael ORTH, Alvaro PASCUAL-LEONE, Irena REKTOROVÁ, Patrik ŠIMKO, John-Paul TAYLOR, Sara TREMBLAY, Yoshikazu UGAWA, Raffaele DUBBIOSO and Federico RANIERI. Diagnostic contribution and therapeutic perspectives of transcranial magnetic stimulation in dementia. \textit{Clinical Neurophysiology}. Clare: Elsevier Ireland, 2021, vol.~132, No~10, p.~2568-2607. ISSN~1388-2457. Available from: https://dx.doi.org/10.1016/j.clinph.2021.05.035.

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