Modulation of Working Memory and Resting-State fMRI by tDCS of the Right Frontoparietal Network

PUPÍKOVÁ, Monika, Patrik ŠIMKO, Martin GAJDOŠ and Irena REKTOROVÁ. Modulation of Working Memory and Resting-State fMRI by tDCS of the Right Frontoparietal Network. Neural Plasticity. LONDON: HINDAWI, 2021, vol. 2021, July 2021, p. 1-9. ISSN 2090-5904. Available from: https://dx.doi.org/10.1155/2021/5594305.

Basic information

• Original name: Modulation of Working Memory and Resting-State fMRI by tDCS of the Right Frontoparietal Network
• Authors: PUPÍKOVÁ, Monika (203 Czech Republic, belonging to the institution), Patrik ŠIMKO (703 Slovakia, belonging to the institution), Martin GAJDOŠ (203 Czech Republic, belonging to the institution) and Irena REKTOROVÁ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Neural Plasticity, LONDON, HINDAWI, 2021, 2090-5904.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30210 Clinical neurology
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 3.144
• RIV identification code: RIV/00216224:14740/21:00120156
• Organization unit: Central European Institute of Technology
• Doi: http://dx.doi.org/10.1155/2021/5594305
• UT WoS: 000683157900001
• Keywords in English: Working Memory; Resting-State fMRI; tDCS of the Right Frontoparietal Network
• Tags: 14110127, CF MAFIL, podil, rivok
• Tags: International impact, Reviewed

Abstract

Many cognitive functions, including working memory, are processed within large-scale brain networks. We targeted the right frontoparietal network (FPN) with one session of transcranial direct current stimulation (tDCS) in an attempt to modulate the cognitive speed of a visual working memory task (WMT) in 27 young healthy subjects using a double-blind crossover design. We further explored the neural underpinnings of induced changes by performing resting-state fMRI prior to and immediately after each stimulation session with the main focus on the interaction between a task-positive FPN and a task-negative default mode network (DMN). Twenty minutes of 2 mA anodal tDCS was superior to sham stimulation in terms of cognitive speed manipulation of a subtask with processing of objects and tools in unconventional views (i.e., the higher cognitive load subtask of the offline WMT). This result was linked to the magnitude of resting-state functional connectivity decreases between the stimulated FPN seed and DMN seeds. We provide the first evidence for the action reappraisal mechanism of object and tool processing. Modulation of cognitive speed of the task by tDCS was reflected by FPN-DMN cross-talk changes.

Links

• LM2018129, research and development project: Name: Národní infrastruktura pro biologické a medicínské zobrazování Czech-BioImaging

Investor: Ministry of Education, Youth and Sports of the CR

• MUNI/A/1465/2020, interní kód MU: Name: Vědomí a kognice u mozkových onemocnění

Investor: Masaryk University

• NV18-04-00256, research and development project: Name: Efekt transkraniální stimulace tDCS na zrakovou pozornost u pacientů s mírnou kognitivní poruchou - studie kombinující MRI a neinvazivní mozkovou stimulaci

Investor: Ministry of Health of the CR