| CORTESE, Mirko, Anil KUMAR, Petr MATULA, Lars KADERALI, Pietro SCATURRO, Holger ERFLE, Eliana Gisela ACOSTA, Sandra BUEHLER, Alessia RUGGIERI, Laurent CHATEL-CHAIX, Karl ROHR and Ralf BARTENSCHLAGER. Reciprocal Effects of Fibroblast Growth Factor Receptor Signaling on Dengue Virus Replication and Virion Production. Cell Reports. CAMBRIDGE, Spojené státy americké: Cell Press, 2019, vol. 27, No 9, p. 2579-2592,"e1"-"e6", 20 pp. ISSN 2211-1247. Available from: https://dx.doi.org/10.1016/j.celrep.2019.04.105. |
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@article{1800137,
author = {Cortese, Mirko and Kumar, Anil and Matula, Petr and Kaderali, Lars and Scaturro, Pietro and Erfle, Holger and Acosta, Eliana Gisela and Buehler, Sandra and Ruggieri, Alessia and ChatelandChaix, Laurent and Rohr, Karl and Bartenschlager, Ralf},
article_location = {CAMBRIDGE, Spojené státy americké},
article_number = {9},
doi = {http://dx.doi.org/10.1016/j.celrep.2019.04.105},
keywords = {host factors; Zika virus; activation; pathway; kinase; identification; residues; mutation},
language = {eng},
issn = {2211-1247},
journal = {Cell Reports},
title = {Reciprocal Effects of Fibroblast Growth Factor Receptor Signaling on Dengue Virus Replication and Virion Production},
url = {https://www.sciencedirect.com/science/article/pii/S2211124719305856},
volume = {27},
year = {2019}
}
TY - JOUR
ID - 1800137
AU - Cortese, Mirko - Kumar, Anil - Matula, Petr - Kaderali, Lars - Scaturro, Pietro - Erfle, Holger - Acosta, Eliana Gisela - Buehler, Sandra - Ruggieri, Alessia - Chatel-Chaix, Laurent - Rohr, Karl - Bartenschlager, Ralf
PY - 2019
TI - Reciprocal Effects of Fibroblast Growth Factor Receptor Signaling on Dengue Virus Replication and Virion Production
JF - Cell Reports
VL - 27
IS - 9
SP - 2579-2592,"e1"-"e6"
EP - 2579-2592,"e1"-"e6"
PB - Cell Press
SN - 22111247
KW - host factors
KW - Zika virus
KW - activation
KW - pathway
KW - kinase
KW - identification
KW - residues
KW - mutation
UR - https://www.sciencedirect.com/science/article/pii/S2211124719305856
N2 - Dengue virus (DENV) is a human arboviral pathogen accounting for 390 million infections every year. The available vaccine has limited efficacy, and DENV-specific drugs have not been generated. To better understand DENV-host cell interaction, we employed RNA interference-based screening of the human kinome and identified fibroblast growth factor receptor 4 (FGFR4) to control the DENV replication cycle. Pharmacological inhibition of FGFR exerts a reciprocal effect by reducing DENV RNA replication and promoting the production of infectious virus particles. Addressing the latter effect, we found that the FGF signaling pathway modulates the intracellular distribution of DENV particles in a PI3K-dependent manner. Upon FGFR inhibition, virions accumulate in the trans-Golgi network compartment, where they undergo enhanced maturation cleavage of the envelope protein precursor membrane (prM), rendering virus particles more infectious. This study reveals an unexpected reciprocal role of a cellular receptor tyrosine kinase regulating DENV RNA replication and the production of infectious virions.
ER -
CORTESE, Mirko, Anil KUMAR, Petr MATULA, Lars KADERALI, Pietro SCATURRO, Holger ERFLE, Eliana Gisela ACOSTA, Sandra BUEHLER, Alessia RUGGIERI, Laurent CHATEL-CHAIX, Karl ROHR and Ralf BARTENSCHLAGER. Reciprocal Effects of Fibroblast Growth Factor Receptor Signaling on Dengue Virus Replication and Virion Production. \textit{Cell Reports}. CAMBRIDGE, Spojené státy americké: Cell Press, 2019, vol.~27, No~9, p.~2579-2592,''e1''-''e6'', 20 pp. ISSN~2211-1247. Available from: https://dx.doi.org/10.1016/j.celrep.2019.04.105.
|
