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@proceedings{1800705,
author = {Tesarova, B and Polanska, H and Smidova, V and Goliášová, Zita},
booktitle = {MENDELNET 2019: PROCEEDINGS OF 26TH INTERNATIONAL PHD STUDENTS CONFERENCE},
keywords = {apoferritin; immune response; nanomedicine; PASylation},
language = {eng},
isbn = {978-80-7509-688-3},
title = {Decreased immune response after PASylation of stealth ferritin nanocarriers},
year = {2019}
}
TY - CONF
ID - 1800705
AU - Tesarova, B - Polanska, H - Smidova, V - Goliášová, Zita
PY - 2019
TI - Decreased immune response after PASylation of stealth ferritin nanocarriers
SN - 9788075096883
KW - apoferritin
KW - immune response
KW - nanomedicine
KW - PASylation
N2 - The effects on immunocompatibility after performed surface modifications (PEGylation and PASylation) of natural nanocarriers based on ferritin (FRT) were tested in this work. Potential cytostatic drug ellipticine (Elli) was encapsulated into FRT, leading to formation of FRTElli. The main goals of prepared PEG-FRTElli, PAS-10-FRTElli and PAS-20-FRTElli were to achieve decreased in vitro macrophage uptake and decreased in vivo complement activation. Macrophage uptake was studied via flow cytometry and complement activation via western blot. According to performed experiments PAS-10 modification was the only one that was sufficient to ensure both aspects.
ER -
TESAROVA, B, H POLANSKA, V SMIDOVA a Zita GOLIÁŠOVÁ. Decreased immune response after PASylation of stealth ferritin nanocarriers. In \textit{MENDELNET 2019: PROCEEDINGS OF 26TH INTERNATIONAL PHD STUDENTS CONFERENCE}. 2019. ISBN~978-80-7509-688-3.
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