VICHOVA, Teodora, Petr WALDAUF, Michal KARPISEK, Jiří JARKOVSKÝ and Zuzana MOTOVSKA. Oxidative stress markers, thioredoxin 1 and 8-isoprostane, in relation to ischemic time in patients with ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention. POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ. KRAKOW: MEDYCYNA PRAKTYCZNA SP K SP ZOO, 2021, vol. 131, 7-8, p. 755-758. ISSN 0032-3772. Available from: https://dx.doi.org/10.20452/pamw.16057.
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Basic information
Original name Oxidative stress markers, thioredoxin 1 and 8-isoprostane, in relation to ischemic time in patients with ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention
Authors VICHOVA, Teodora (203 Czech Republic), Petr WALDAUF (203 Czech Republic), Michal KARPISEK (203 Czech Republic), Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution) and Zuzana MOTOVSKA (203 Czech Republic, guarantor).
Edition POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ, KRAKOW, MEDYCYNA PRAKTYCZNA SP K SP ZOO, 2021, 0032-3772.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30218 General and internal medicine
Country of publisher Poland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 5.218
RIV identification code RIV/00216224:14110/21:00122749
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.20452/pamw.16057
UT WoS 000700888500028
Keywords in English Oxidative stress markers; thioredoxin 1 and 8-isoprostane; ischemic time; myocardial infarction
Tags 14119612, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 5/11/2021 10:23.
Abstract
The extent of ischemia-reperfusion injury (IRI) significantly affects the prognosis of patients with ST-segment elevation myocardial infarction (STEMI). Excessive generation of reactive oxygen species during ischemia and subsequent reperfusion leads to cellular necrosis and apoptosis. These processes contribute to the impairment of microcirculation and the no-reflow phenomenon, development and progression of left ventricular remodeling and failure. Out of numerous factors affecting the complex process of IRI, the duration of ischemia is of major importance. Prolonged ischemia has been associated with higher degree of oxidative stress, but only scarce evidence is available up to date.2 Our goal was to evaluate selected markers of oxidative stress in relation to reperfusion via primary percutaneous coronary intervention (pPCI) and their potential correlation with the duration of ischemia, defined as time delay between symptom onset and reperfusion.
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