J 2021

Oxidative stress markers, thioredoxin 1 and 8-isoprostane, in relation to ischemic time in patients with ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention

VICHOVA, Teodora, Petr WALDAUF, Michal KARPISEK, Jiří JARKOVSKÝ, Zuzana MOTOVSKA et. al.

Basic information

Original name

Oxidative stress markers, thioredoxin 1 and 8-isoprostane, in relation to ischemic time in patients with ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention

Authors

VICHOVA, Teodora (203 Czech Republic), Petr WALDAUF (203 Czech Republic), Michal KARPISEK (203 Czech Republic), Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution) and Zuzana MOTOVSKA (203 Czech Republic, guarantor)

Edition

POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ, KRAKOW, MEDYCYNA PRAKTYCZNA SP K SP ZOO, 2021, 0032-3772

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30218 General and internal medicine

Country of publisher

Poland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 5.218

RIV identification code

RIV/00216224:14110/21:00122749

Organization unit

Faculty of Medicine

DOI

UT WoS

000700888500028

Keywords in English

Oxidative stress markers; thioredoxin 1 and 8-isoprostane; ischemic time; myocardial infarction

Tags

Tags

International impact, Reviewed
Změněno: 5/11/2021 10:23, Mgr. Tereza Miškechová

Abstract

V originále

The extent of ischemia-reperfusion injury (IRI) significantly affects the prognosis of patients with ST-segment elevation myocardial infarction (STEMI). Excessive generation of reactive oxygen species during ischemia and subsequent reperfusion leads to cellular necrosis and apoptosis. These processes contribute to the impairment of microcirculation and the no-reflow phenomenon, development and progression of left ventricular remodeling and failure. Out of numerous factors affecting the complex process of IRI, the duration of ischemia is of major importance. Prolonged ischemia has been associated with higher degree of oxidative stress, but only scarce evidence is available up to date.2 Our goal was to evaluate selected markers of oxidative stress in relation to reperfusion via primary percutaneous coronary intervention (pPCI) and their potential correlation with the duration of ischemia, defined as time delay between symptom onset and reperfusion.